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Fxr2 FMR1 autosomal homolog 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287433, updated on 2-Nov-2024

Summary

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Official Symbol
Fxr2provided by RGD
Official Full Name
FMR1 autosomal homolog 2provided by RGD
Primary source
RGD:1307011
See related
EnsemblRapid:ENSRNOG00000011876 AllianceGenome:RGD:1307011
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fxr2h
Summary
Predicted to enable mRNA 3'-UTR binding activity; protein dimerization activity; and translation regulator activity. Predicted to be involved in several processes, including dentate gyrus development; positive regulation of long-term neuronal synaptic plasticity; and post-transcriptional regulation of gene expression. Predicted to be located in cytosol; dendrite; and ribosome. Predicted to be active in several cellular components, including cytoplasmic stress granule; glutamatergic synapse; and postsynapse. Orthologous to human FXR2 (FMR1 autosomal homolog 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 279.9), Heart (RPKM 242.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fxr2 in Genome Data Viewer
Location:
10q24
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (54849345..54869713)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (54350577..54370964)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (56237814..56257877)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480815 Neighboring gene sex hormone binding globulin Neighboring gene spermidine/spermine N1-acetyltransferase family member 2 Neighboring gene SRY-box transcription factor 15 Neighboring gene mannose-P-dolichol utilization defect 1 Neighboring gene Cd68 molecule

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The functional significance of absence: the chromosomal segment harboring Tp53 is absent from the T55 rat radiation hybrid mapping panel. Behboudi A, et al. Genomics, 2002 Jun. PMID 12036299
  2. On the aggregation properties of FMRP--a link with the FXTAS syndrome? Sjekloća L, et al. FEBS J, 2011 Jun. PMID 21446998
  3. Sub-synaptic, multiplexed analysis of proteins reveals Fragile X related protein 2 is mislocalized in Fmr1 KO synapses. Wang GX, et al. Elife, 2016 Oct 22. PMID 27770568, Free PMC Article
  4. The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2. Zhang Y, et al. EMBO J, 1995 Nov 1. PMID 7489725, Free PMC Article
  5. Fragile X related protein 1 clusters with ribosomes and messenger RNAs at a subset of dendritic spines in the mouse hippocampus. Cook D, et al. PLoS One, 2011. PMID 22022532, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables translation regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in animal organ development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dentate gyrus development ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA destabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of long-term neuronal synaptic plasticity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mRNA stability IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of translation at presynapse, modulating synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasmic stress granule IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
  
located_in presynapse IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
RNA-binding protein FXR2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100647.1 → NP_001094117.1  RNA-binding protein FXR2

    See identical proteins and their annotated locations for NP_001094117.1

    Status: PROVISIONAL

    Source sequence(s)
    BC160929
    UniProtKB/TrEMBL
    A0A8J8YNR6, B1H2A6, F1M3Y6
    Related
    ENSRNOP00000016163.7, ENSRNOT00000016163.9
    Conserved Domains (7) summary
    pfam12235
    Location:364 → 475
    FXMRP1_C_core; Fragile X-related 1 protein core C terminal
    pfam16096
    Location:512 → 579
    FXR_C1; Fragile X-related 1 protein C-terminal region 2
    cd20473
    Location:13 → 67
    Tudor_Agenet_FXR2_rpt1; first Tudor-like Agenet domain found in fragile X mental retardation syndrome-related protein 2 (FXR2) and similar proteins
    cd20476
    Location:69 → 136
    Tudor_Agenet_FXR2_rpt2; second Tudor-like Agenet domain found in fragile X mental retardation syndrome-related protein 2 (FXR2) and similar proteins
    cd22505
    Location:133 → 209
    KH_I_FXR2_rpt1; first type I K homology (KH) RNA-binding domain found in fragile X mental retardation syndrome-related protein 2 (FXR2) and similar proteins
    cd22508
    Location:228 → 290
    KH_I_FXR2_rpt2; second type I K homology (KH) RNA-binding domain found in fragile X mental retardation syndrome-related protein 2 (FXR2) and similar proteins
    cd22511
    Location:291 → 368
    KH_I_FXR2_rpt3; third type I K homology (KH) RNA-binding domain found in fragile X mental retardation syndrome-related protein 2 (FXR2) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    54849345..54869713
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039085448.2 → XP_038941376.1  RNA-binding protein FXR2 isoform X1

    UniProtKB/TrEMBL
    A0A8J8YNR6
    Conserved Domains (7) summary
    pfam12235
    Location:363 → 474
    FXMRP1_C_core; Fragile X-related 1 protein core C terminal
    pfam16096
    Location:511 → 578
    FXR_C1; Fragile X-related 1 protein C-terminal region 2
    cd20476
    Location:68 → 135
    Tudor_Agenet_FXR2_rpt2; second Tudor-like Agenet domain found in fragile X mental retardation syndrome-related protein 2 (FXR2) and similar proteins
    cd22505
    Location:132 → 208
    KH_I_FXR2_rpt1; first type I K homology (KH) RNA-binding domain found in fragile X mental retardation syndrome-related protein 2 (FXR2) and similar proteins
    cd22508
    Location:227 → 289
    KH_I_FXR2_rpt2; second type I K homology (KH) RNA-binding domain found in fragile X mental retardation syndrome-related protein 2 (FXR2) and similar proteins
    cd22511
    Location:290 → 367
    KH_I_FXR2_rpt3; third type I K homology (KH) RNA-binding domain found in fragile X mental retardation syndrome-related protein 2 (FXR2) and similar proteins
    cl02573
    Location:44 → 66
    Tudor_SF; Tudor domain superfamily
Nucleotide Protein Strain
Heading Accession and Version

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