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Dhrs7c dehydrogenase/reductase 7C [ Rattus norvegicus (Norway rat) ]

Gene ID: 287411, updated on 2-Nov-2024

Summary

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Official Symbol
Dhrs7cprovided by RGD
Official Full Name
dehydrogenase/reductase 7Cprovided by RGD
Primary source
RGD:1306989
See related
EnsemblRapid:ENSRNOG00000026548 AllianceGenome:RGD:1306989
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1306989
Summary
Predicted to enable all-trans-retinol dehydrogenase (NAD+) activity. Predicted to be involved in D-glucose import; intracellular calcium ion homeostasis; and regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum. Predicted to be located in longitudinal sarcoplasmic reticulum and sarcoplasmic reticulum membrane. Orthologous to human DHRS7C (dehydrogenase/reductase 7C). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 1220.2) and Heart (RPKM 581.2) See more
Orthologs
human mouse all
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Genomic context

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See Dhrs7c in Genome Data Viewer
Location:
10q24
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (52994205..53012281)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (52495262..52513338)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (54352270..54370653)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene glucagon-like peptide 2 receptor Neighboring gene GSG1-like 2 Neighboring gene ubiquitin specific peptidase 43 Neighboring gene uncharacterized LOC100911946

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. SRP-35, a newly identified protein of the skeletal muscle sarcoplasmic reticulum, is a retinol dehydrogenase. Treves S, et al. Biochem J, 2012 Jan 15. PMID 21995425
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables all-trans-retinol dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
  
enables all-trans-retinol dehydrogenase (NAD+) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in D-glucose import ISO
Inferred from Sequence Orthology
more info
  
involved_in D-glucose import ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in intracellular calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular calcium ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in longitudinal sarcoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in longitudinal sarcoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in sarcoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in sarcoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
dehydrogenase/reductase SDR family member 7C
Names
dehydrogenase/reductase (SDR family) member 7C
sarcoplasmic reticulum protein of 35 kDa
short-chain dehydrogenase/reductase family 32C member 2
NP_001258526.1
NP_001258527.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271597.1 → NP_001258526.1  dehydrogenase/reductase SDR family member 7C isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A6HFJ2
    Conserved Domains (1) summary
    cl21454
    Location:35 → 214
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  2. NM_001271598.1 → NP_001258527.1  dehydrogenase/reductase SDR family member 7C isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    FM120380, FN805189, JAXUCZ010000010
    UniProtKB/Swiss-Prot
    D3ZGP9
    Related
    ENSRNOP00000031559.4, ENSRNOT00000036752.8
    Conserved Domains (2) summary
    cd05332
    Location:35 → 296
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs
    PRK06181
    Location:37 → 293
    PRK06181; short chain dehydrogenase; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    52994205..53012281
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3ZGP9.1 GenPept UniProtKB/Swiss-Prot:D3ZGP9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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