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Flii FLII, actin remodeling protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 287375, updated on 2-Nov-2024

Summary

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Official Symbol
Fliiprovided by RGD
Official Full Name
FLII, actin remodeling proteinprovided by RGD
Primary source
RGD:1307590
See related
EnsemblRapid:ENSRNOG00000004159 AllianceGenome:RGD:1307590
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fliih
Summary
Predicted to enable actin filament binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in actin cytoskeleton organization; actin filament severing; and barbed-end actin filament capping. Predicted to be located in several cellular components, including brush border; centriolar satellite; and nucleoplasm. Predicted to be active in actin cytoskeleton; cytoplasm; and nucleus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human FLII (FLII actin remodeling protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 341.5), Heart (RPKM 328.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Flii in Genome Data Viewer
Location:
10q22
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (45893566..45907547, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (45394032..45408051, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (46955460..46969468, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene myosin XVA Neighboring gene U7 small nuclear RNA Neighboring gene alkB homolog 5, RNA demethylase Neighboring gene ribosomal protein L17 like 5 Neighboring gene LLGL scribble cell polarity complex component 1 Neighboring gene small nucleolar RNA SNORA15 Neighboring gene mitochondrial elongation factor 2 Neighboring gene DNA topoisomerase III alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Decreased expression of Flightless I, a gelsolin family member and developmental regulator, in early-gestation fetal wounds improves healing. Lin CH, et al. Mamm Genome, 2011 Jun. PMID 21400204
  2. Regeneration of hair follicles is modulated by flightless I (Flii) in a rodent vibrissa model. Waters JM, et al. J Invest Dermatol, 2011 Apr. PMID 21191408
  3. Fliih, a gelsolin-related cytoskeletal regulator essential for early mammalian embryonic development. Campbell HD, et al. Mol Cell Biol, 2002 May. PMID 11971982, Free PMC Article
  4. Identification of the binding partners for flightless I, A novel protein bridging the leucine-rich repeat and the gelsolin superfamilies. Liu YT, et al. J Biol Chem, 1998 Apr 3. PMID 9525888
  5. A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins. Revenu C, et al. Mol Biol Cell, 2012 Jan. PMID 22114352, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Decreased expression of Flightless I in early-gestation fetal wounds improves healing.
    Title: Decreased expression of Flightless I, a gelsolin family member and developmental regulator, in early-gestation fetal wounds improves healing.
  2. Flii appears to have a positive role in the regeneration of hair follicles, contrary to its negative influence on wound healing in skin
    Title: Regeneration of hair follicles is modulated by flightless I (Flii) in a rodent vibrissa model.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC94344

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin binding ISO
Inferred from Sequence Orthology
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin filament severing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin polymerization or depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in barbed-end actin filament capping IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in myofibril assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sarcomere organization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in brush border ISO
Inferred from Sequence Orthology
more info
  
located_in centriolar satellite IEA
Inferred from Electronic Annotation
more info
  
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in podosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein flightless-1 homolog
Names
flightless I actin binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008279.1 → NP_001008280.1  protein flightless-1 homolog

    See identical proteins and their annotated locations for NP_001008280.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085829
    UniProtKB/TrEMBL
    Q5RKI5
    Related
    ENSRNOP00000006753.6, ENSRNOT00000006753.7
    Conserved Domains (8) summary
    cd11280
    Location:619 → 703
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1054 → 1153
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:492 → 604
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:1164 → 1263
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:723 → 837
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd00116
    Location:89 → 375
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:106 → 128
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:131 → 186
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    45893566..45907547 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006246468.5 → XP_006246530.1  protein flightless-1 homolog isoform X1

    UniProtKB/TrEMBL
    F7F0E5
    Conserved Domains (8) summary
    cd11280
    Location:618 → 702
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1053 → 1152
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:491 → 603
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:1163 → 1262
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:722 → 836
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd00116
    Location:89 → 375
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:106 → 128
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:131 → 186
    LRR_8; Leucine rich repeat
Nucleotide Protein Strain
Heading Accession and Version

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