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Timd2 T-cell immunoglobulin and mucin domain containing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287222, updated on 2-Nov-2024

Summary

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Official Symbol
Timd2provided by RGD
Official Full Name
T-cell immunoglobulin and mucin domain containing 2provided by RGD
Primary source
RGD:1359571
See related
EnsemblRapid:ENSRNOG00000021345 AllianceGenome:RGD:1359571
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tim2
Summary
Predicted to enable ferritin receptor activity; phosphatidylserine binding activity; and virus receptor activity. Predicted to be involved in phagocytosis, engulfment and positive regulation of mast cell activation. Predicted to act upstream of or within iron ion transport. Predicted to be located in plasma membrane. Predicted to be active in cell surface. Human ortholog(s) of this gene implicated in atopic dermatitis. Orthologous to human HAVCR1 (hepatitis A virus cellular receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 499.5), Kidney (RPKM 42.7) and 1 other tissue See more
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Genomic context

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See Timd2 in Genome Data Viewer
Location:
10q21
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (31561563..31602515, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (31060308..31101262, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (31755473..31796423, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene hepatitis A virus cellular receptor 1 like 2 Neighboring gene developmental pluripotency associated 1 Neighboring gene lysine methyltransferase 5A, pseudogene 2 Neighboring gene hepatitis A virus cellular receptor 1 Neighboring gene surfeit 6, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Iron uptake mediated by binding of H-ferritin to the TIM-2 receptor in mouse cells. Han J, et al. PLoS One, 2011. PMID 21886823, Free PMC Article
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC108812

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ferritin receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables virus receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within iron ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in phagocytosis, engulfment IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of mast cell activation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in symbiont entry into host cell IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
T-cell immunoglobulin and mucin domain-containing protein 2
Names
T-cell immunoglobulin mucin receptor 2
T-cell membrane protein 2
TIM-2
TIMD-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013855.1 → NP_001013877.1  T-cell immunoglobulin and mucin domain-containing protein 2 precursor

    See identical proteins and their annotated locations for NP_001013877.1

    Status: PROVISIONAL

    Source sequence(s)
    BC089832
    UniProtKB/Swiss-Prot
    Q5FVR0
    Related
    ENSRNOP00000056223.2, ENSRNOT00000059468.5
    Conserved Domains (2) summary
    smart00410
    Location:21 → 124
    IG_like; Immunoglobulin like
    pfam07686
    Location:23 → 107
    V-set; Immunoglobulin V-set domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    31561563..31602515 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006246168.4 → XP_006246230.1  T-cell immunoglobulin and mucin domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006246230.1

    UniProtKB/Swiss-Prot
    Q5FVR0
    Conserved Domains (2) summary
    smart00410
    Location:21 → 124
    IG_like; Immunoglobulin like
    pfam07686
    Location:23 → 107
    V-set; Immunoglobulin V-set domain

  2. XM_008767669.4 → XP_008765891.1  T-cell immunoglobulin and mucin domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_008765891.1

    UniProtKB/Swiss-Prot
    Q5FVR0
    Conserved Domains (2) summary
    smart00410
    Location:21 → 124
    IG_like; Immunoglobulin like
    pfam07686
    Location:23 → 107
    V-set; Immunoglobulin V-set domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5FVR0.1 GenPept UniProtKB/Swiss-Prot:Q5FVR0

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