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Hba-a3 hemoglobin alpha, adult chain 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287167, updated on 2-Nov-2024

Summary

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Official Symbol
Hba-a3provided by RGD
Official Full Name
hemoglobin alpha, adult chain 3provided by RGD
Primary source
RGD:1359209
See related
AllianceGenome:RGD:1359209
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
GloA; Glnc1; Hba-a1
Summary
Enables heme binding activity and organic acid binding activity. Contributes to oxygen binding activity. Predicted to be involved in several processes, including hydrogen peroxide catabolic process; nitric oxide transport; and oxygen transport. Part of hemoglobin complex. Human ortholog(s) of this gene implicated in Heinz body anemia; alpha thalassemia; familial erythrocytosis 7; and hemoglobin H disease. Orthologous to human HBA1 (hemoglobin subunit alpha 1) and HBA2 (hemoglobin subunit alpha 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 20902.6), Lung (RPKM 5598.0) and 1 other tissue See more
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Genomic context

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See Hba-a3 in Genome Data Viewer
Location:
10q12
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (15816099..15816943, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (15311637..15312481, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (15577249..15577977, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene LUC7-like Neighboring gene small nucleolar RNA U13 Neighboring gene hemoglobin, theta 1 Neighboring gene hemoglobin subunit theta-1-like Neighboring gene hemoglobin alpha, adult chain 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. α-Haemoglobin regulates sympathoadrenal cell metabolism to maintain a catecholaminergic phenotype. Marcos-Almaraz MT, et al. Biochem J, 2012 Feb 1. PMID 22060312
  2. Three cysteine residues in the alpha chain of rat haemoglobin (albino Rattus norvegicus): 13 (A 11), 104 (G 11) and 111 (G 18). Chua CG, et al. Biochim Biophys Acta, 1974 Oct 9. PMID 4429672
  3. Structural, functional and conformational properties of rat hemoglobins. John ME. Eur J Biochem, 1982 May 17. PMID 6284505
  4. Hemopressin: a novel bioactive peptide derived from the alpha1-chain of hemoglobin. Dale CS, et al. Mem Inst Oswaldo Cruz, 2005 Mar. PMID 15962106
  5. Evidence of hemoglobin binding to arsenic as a basis for the accumulation of arsenic in rat blood. Lu M, et al. Chem Res Toxicol, 2004 Dec. PMID 15606151

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to haptoglobin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to haptoglobin binding ISO
Inferred from Sequence Orthology
more info
  
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heme binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables organic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables organic acid binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to oxygen binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxygen carrier activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to peroxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
  
involved_in hydrogen peroxide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hydrogen peroxide catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in nitric oxide transport ISO
Inferred from Sequence Orthology
more info
  
involved_in oxygen transport ISO
Inferred from Sequence Orthology
more info
  
involved_in response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
part_of haptoglobin-hemoglobin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of haptoglobin-hemoglobin complex ISO
Inferred from Sequence Orthology
more info
  
part_of hemoglobin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of hemoglobin complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of hemoglobin complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
hemoglobin alpha, adult chain 3
Names
alpha-globin
globin c1
globin, alpha
hemoglobin alpha, adult chain 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013853.2 → NP_001013875.1  hemoglobin alpha, adult chain 3

    See identical proteins and their annotated locations for NP_001013875.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A0G2JSV6, A0A9K3Y8D0, Q63910
    Conserved Domains (1) summary
    cd08927
    Location:3 → 142
    Hb-alpha_like; Hemoglobin alpha, zeta, mu, theta, and related Hb subunits

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    15816099..15816943 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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