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Hcfc1r1 host cell factor C1 regulator 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287097, updated on 17-Aug-2024

Summary

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Official Symbol
Hcfc1r1provided by RGD
Official Full Name
host cell factor C1 regulator 1provided by RGD
Primary source
RGD:727975
See related
AllianceGenome:RGD:727975
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Hpip
Summary
Predicted to be located in nucleoplasm. Orthologous to human HCFC1R1 (host cell factor C1 regulator 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 332.0), Kidney (RPKM 183.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
10q12
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (13209757..13211445)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (12705139..12706852)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (12994229..12995674)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene matrix metallopeptidase 25 Neighboring gene uncharacterized LOC102557038 Neighboring gene BICD family like cargo adaptor 2 Neighboring gene THO complex subunit 6 Neighboring gene TNF receptor superfamily member 12A Neighboring gene claudin 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
host cell factor C1 regulator 1
Names
HCF-1 beta-propeller-interacting protein
host cell factor C1 regulator 1 (XPO1-dependent)
inhibitor of four 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100492.1 → NP_001093962.1  host cell factor C1 regulator 1

    See identical proteins and their annotated locations for NP_001093962.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AY245001, BC168753, BG373213, FM050402
    UniProtKB/Swiss-Prot
    Q80V38
    UniProtKB/TrEMBL
    A6HCK4, A6HCK7
    Conserved Domains (1) summary
    pfam15226
    Location:2 → 112
    HPIP; HCF-1 beta-propeller-interacting protein family

  2. NM_001185047.1 → NP_001171976.1  host cell factor C1 regulator 1

    See identical proteins and their annotated locations for NP_001171976.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC168753, BG373213, CB698538
    UniProtKB/Swiss-Prot
    Q80V38
    UniProtKB/TrEMBL
    A6HCK4, A6HCK7
    Conserved Domains (1) summary
    pfam15226
    Location:2 → 112
    HPIP; HCF-1 beta-propeller-interacting protein family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    13209757..13211445
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039085345.2 → XP_038941273.1  host cell factor C1 regulator 1 isoform X1

    Conserved Domains (1) summary
    pfam15226
    Location:60 → 127
    HPIP; HCF-1 beta-propeller-interacting protein family

  2. XM_039085346.2 → XP_038941274.1  host cell factor C1 regulator 1 isoform X2

    UniProtKB/Swiss-Prot
    Q80V38
    UniProtKB/TrEMBL
    A6HCK4, A6HCK7
    Conserved Domains (1) summary
    pfam15226
    Location:2 → 112
    HPIP; HCF-1 beta-propeller-interacting protein family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80V38.2 GenPept UniProtKB/Swiss-Prot:Q80V38

Gene LinkOut

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