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Tnfrsf17 TNF receptor superfamily member 17 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287034, updated on 4-Jan-2025

Summary

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Official Symbol
Tnfrsf17provided by RGD
Official Full Name
TNF receptor superfamily member 17provided by RGD
Primary source
RGD:1304703
See related
AllianceGenome:RGD:1304703
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable signaling receptor activity. Predicted to be involved in tumor necrosis factor-mediated signaling pathway. Predicted to act upstream of or within lymphocyte homeostasis. Human ortholog(s) of this gene implicated in colon carcinoma and multiple myeloma. Orthologous to human TNFRSF17 (TNF receptor superfamily member 17). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Spleen (RPKM 27.3), Thymus (RPKM 20.0) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tnfrsf17 in Genome Data Viewer
Location:
10q11
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (4808023..4813857, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (4301023..4306889, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (4252097..4258335, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095243 Neighboring gene sorting nexin 29 Neighboring gene uncharacterized LOC134480744 Neighboring gene uncharacterized LOC120095016 Neighboring gene G1 to S phase transition 1 Neighboring gene uncharacterized LOC100911627

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A soluble form of B cell maturation antigen, a receptor for the tumor necrosis factor family member APRIL, inhibits tumor cell growth. Rennert P, et al. J Exp Med, 2000 Dec 4. PMID 11104810, Free PMC Article
  2. Graft-versus-tumor response in patients with multiple myeloma is associated with antibody response to BCMA, a plasma-cell membrane receptor. Bellucci R, et al. Blood, 2005 May 15. PMID 15692072, Free PMC Article
  3. BCMA is essential for the survival of long-lived bone marrow plasma cells. O'Connor BP, et al. J Exp Med, 2004 Jan 5. PMID 14707116, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within lymphocyte homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in tumor necrosis factor-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tumor necrosis factor receptor superfamily member 17
Names
tumor necrosis factor receptor superfamily, member 17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105761.1 → NP_001099231.1  tumor necrosis factor receptor superfamily member 17

    See identical proteins and their annotated locations for NP_001099231.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474017
    UniProtKB/TrEMBL
    A6K4H4, D3ZKQ8
    Conserved Domains (1) summary
    cd13414
    Location:1 → 165
    TNFRSF17; Tumor necrosis factor receptor superfamily member 17 (TNFRSF17), also known as B cell maturation antigen (BCMA), as well as TNFRSF13A

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    4808023..4813857 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017597054.3 → XP_017452543.1  tumor necrosis factor receptor superfamily member 17 isoform X1

    UniProtKB/TrEMBL
    A6K4H4, D3ZKQ8
    Conserved Domains (1) summary
    cd13414
    Location:1 → 165
    TNFRSF17; Tumor necrosis factor receptor superfamily member 17 (TNFRSF17), also known as B cell maturation antigen (BCMA), as well as TNFRSF13A
Nucleotide Protein Strain
Heading Accession and Version

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