UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: UQCRFS1provided by VGNC
Official Full Name: ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1provided by VGNC
Primary source: VGNC:VGNC:53044
See related: BGD:BT18705
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: RISP
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	18	NC_037345.1 (997260..1002042, complement)

Chromosome 18 - NC_037345.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037345.1 Chromosome 18 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This is the first direct demonstration that histidine is the redox-linked protonation site of the Rieske iron-sulfur protein subunit of cytochrome bc1.
Title: Direct observation of redox-linked histidine protonation changes in the iron-sulfur protein of the cytochrome bc1 complex by ATR-FTIR spectroscopy.
Three hydrogen-bond mutant Rieske clusters all have decreased cluster reduction potentials and increased cluster pK values consistent with the removal of a hydrogen-bonding dipole, which preferentially stabilizes the most negatively charged state.
Title: Roles of the disulfide bond and adjacent residues in determining the reduction potentials and stabilities of respiratory-type Rieske clusters.
in the normal catalytic cycle of the bc(1) complex, the [2Fe-2S] cluster may function as a proton-exiting gate
Title: The iron-sulfur cluster of the Rieske iron-sulfur protein functions as a proton-exiting gate in the cytochrome bc(1) complex.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH143354 (e-PCR)
- UniSTS:232601

UQCRFS1 (e-PCR)
- UniSTS:279245

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables 2 iron, 2 sulfur cluster binding	IEA Inferred from Electronic Annotation more info	PubMed
enables ubiquinol-cytochrome-c reductase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in mitochondrial electron transport, ubiquinol to cytochrome c	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: cytochrome b-c1 complex subunit Rieske, mitochondrial

Names: Rieske iron-sulfur protein; Rieske protein UQCRFS1; complex III subunit 5; cytochrome b-c1 complex subunit 5; ubiquinol-cytochrome c reductase iron-sulfur subunit

NP_777238.1

EC 7.1.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174813.2 → NP_777238.1 cytochrome b-c1 complex subunit Rieske, mitochondrial precursor

See identical proteins and their annotated locations for NP_777238.1

Status: PROVISIONAL

Source sequence(s)

M34336

UniProtKB/Swiss-Prot

P13272

Conserved Domains (4) summary

cd03470
Location:146 → 269

Rieske_cytochrome_bc1; Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including ...

TIGR01416
Location:109 → 269

Rieske_proteo; ubiquinol-cytochrome c reductase, iron-sulfur subunit

pfam02921
Location:75 → 140

UCR_TM; Ubiquinol cytochrome reductase transmembrane region

pfam09165
Location:2 → 72

Ubiq-Cytc-red_N; Ubiquinol-cytochrome c reductase 8 kDa, N-terminal