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GPX4 glutathione peroxidase 4 [ Bos taurus (domestic cattle) ]

Gene ID: 286809, updated on 4-Oct-2024

Summary

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Official Symbol
GPX4provided by VGNC
Official Full Name
glutathione peroxidase 4provided by VGNC
Primary source
VGNC:VGNC:106759
See related
Ensembl:ENSBTAG00000053003
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
PHGPx
Summary
The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development. Disruption of this gene in mouse spermatocytes is associated with male infertility. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2016]
Orthologs
human mouse all
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Genomic context

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See GPX4 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (43588660..43591107)

Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132345740 Neighboring gene Rho GTPase activating protein 45 Neighboring gene RNA polymerase II, I and III subunit E Neighboring gene strawberry notch homolog 2 Neighboring gene serine/threonine kinase 11 Neighboring gene CACN subunit beta associated regulatory protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Estrogen selectively up-regulates the phospholipid hydroperoxide glutathione peroxidase in the oviducts. Lapointe J, et al. Endocrinology, 2005 Jun. PMID 15746255
  2. Characterization of mammalian selenoproteomes. Kryukov GV, et al. Science, 2003 May 30. PMID 12775843
  3. The small GTPase RAB28 is required for phagocytosis of cone outer segments by the murine retinal pigmented epithelium. Ying G, et al. J Biol Chem, 2018 Nov 9. PMID 30228185, Free PMC Article
  4. Characterization of gene expression profiles in early bovine pregnancy using a custom cDNA microarray. Ishiwata H, et al. Mol Reprod Dev, 2003 May. PMID 12658628
  5. Composition and evolution of the vertebrate and mammalian selenoproteomes. Mariotti M, et al. PLoS One, 2012. PMID 22479358, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GPx-4 has an important role in the physiological control of peroxide tone in the bordering cells of the oviductal lumen
    Title: Estrogen selectively up-regulates the phospholipid hydroperoxide glutathione peroxidase in the oviducts.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables glutathione peroxidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
phospholipid hydroperoxide glutathione peroxidase
Names
GPx-4
GSHPx-4
glutathione peroxidase 4 (phospholipid hydroperoxidase)
phospholipid hydroperoxide glutathione peroxidase, mitochondrial
NP_001333359.1
NP_001333360.1
NP_777195.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346430.1 → NP_001333359.1  phospholipid hydroperoxide glutathione peroxidase isoform B

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon compared to variant 1. The resulting isoform (B) has a longer and a distinct N-terminus compared to isoform A.
    Source sequence(s)
    DT835990, DV828741, EV607600

  2. NM_001346431.1 → NP_001333360.1  phospholipid hydroperoxide glutathione peroxidase isoform C

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon compared to variant 1. The resulting isoform (C) has a longer and a distinct N-terminus compared to isoform A.
    Source sequence(s)
    DV828741, EH125462, EV607600

  3. NM_174770.4 → NP_777195.1  phospholipid hydroperoxide glutathione peroxidase isoform A precursor

    See identical proteins and their annotated locations for NP_777195.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes the canonical isoform A. A similar isoform in rat has been shown to be localized to the mitochondria (PMID:9988735).
    Source sequence(s)
    BC102957, DT839524, DV828741
    UniProtKB/Swiss-Prot
    Q9N2J2
    UniProtKB/TrEMBL
    A0AAA9TKX9
    Related
    ENSBTAP00000067758.1, ENSBTAT00000070793.2
    Conserved Domains (1) summary
    cd00340
    Location:40 → 193
    GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    43588660..43591107
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9N2J2.2 GenPept UniProtKB/Swiss-Prot:Q9N2J2

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