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msna moesin a [ Danio rerio (zebrafish) ]

Gene ID: 286739, updated on 18-Sep-2024

Summary

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Official Symbol
msnaprovided by ZNC
Official Full Name
moesin aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-021211-2
See related
Ensembl:ENSDARG00000058128 AllianceGenome:ZFIN:ZDB-GENE-021211-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
rdx; cb567; zgc:85640; wu:fb14b03
Summary
Predicted to enable actin binding activity and cell adhesion molecule binding activity. Acts upstream of or within blood vessel lumenization and endoderm development. Predicted to be located in cytoplasm; cytoskeleton; and membrane. Predicted to be active in several cellular components, including adherens junction; filopodium; and microvillus. Is expressed in several structures, including cardiovascular system; gut; hypochord; nervous system; and swim bladder bud. Human ortholog(s) of this gene implicated in immunodeficiency 50. Orthologous to human MSN (moesin). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See msna in Genome Data Viewer
Location:
chromosome: 5
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (22133375..22174040)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (21629575..21670237)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene zinc finger CCCH-type containing 12B Neighboring gene uncharacterized LOC110438643 Neighboring gene LAS1 like ribosome biogenesis factor Neighboring gene ferredoxin 1b Neighboring gene uncharacterized LOC137495581 Neighboring gene microRNA 223

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Moesin signalling induces F9 teratocarcinoma cells to differentiate into primitive extraembryonic endoderm. Krawetz R, et al. Cell Signal, 2008 Jan. PMID 17993262
  2. The hyaloid vasculature facilitates basement membrane breakdown during choroid fissure closure in the zebrafish eye. James A, et al. Dev Biol, 2016 Nov 15. PMID 27634568, Free PMC Article
  3. Radixin is a constituent of stereocilia in hair cells. Pataky F, et al. Proc Natl Acad Sci U S A, 2004 Feb 24. PMID 14983055, Free PMC Article
  4. Tol2 gene trap integrations in the zebrafish amyloid precursor protein genes appa and aplp2 reveal accumulation of secreted APP at the embryonic veins. Liao HK, et al. Dev Dyn, 2012 Feb. PMID 22275008, Free PMC Article
  5. Control of directed cell migration in vivo by membrane-to-cortex attachment. Diz-Muñoz A, et al. PLoS Biol, 2010 Nov 30. PMID 21151339, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. suggest that Ve-cadherin and Moesin1 function to establish and maintain apical/basal polarity during multicellular lumen formation in the intersegmental vessels
    Title: Moesin1 and Ve-cadherin are required in endothelial cells during in vivo tubulogenesis.
  2. results suggest a new role for moesin, acting in a signalling pathway facilitating the differentiation of extraembryonic endoderm
    Title: Moesin signalling induces F9 teratocarcinoma cells to differentiate into primitive extraembryonic endoderm.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC85640

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables cell adhesion molecule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytoskeletal protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within blood vessel lumenization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in developmental process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within endoderm development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of early endosome to late endosome transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of protein localization to early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of organelle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
is_active_in apical part of cell IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in filopodium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in microvillus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
moesin a
Names
moesin1
msn1
radixin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004296.1 → NP_001004296.1  moesin a

    See identical proteins and their annotated locations for NP_001004296.1

    Status: PROVISIONAL

    Source sequence(s)
    BC081551
    UniProtKB/Swiss-Prot
    A0A8M1N247, A2CF04, Q66I42
    Related
    ENSDARP00000017246.8, ENSDART00000016214.9
    Conserved Domains (5) summary
    smart00295
    Location:7 → 206
    B41; Band 4.1 homologues
    cd13194
    Location:200 → 296
    FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
    pfam00373
    Location:91 → 206
    FERM_M; FERM central domain
    pfam00769
    Location:347 → 579
    ERM; Ezrin/radixin/moesin family
    pfam09379
    Location:9 → 71
    FERM_N; FERM N-terminal domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    22133375..22174040
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009301281.4 → XP_009299556.1  moesin a isoform X1

    UniProtKB/TrEMBL
    A0A8M3B2A2
    Conserved Domains (5) summary
    smart00295
    Location:1 → 195
    B41; Band 4.1 homologues
    cd13194
    Location:189 → 285
    FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
    pfam00373
    Location:80 → 195
    FERM_M; FERM central domain
    pfam00769
    Location:336 → 568
    ERM; Ezrin/radixin/moesin family
    pfam09379
    Location:2 → 60
    FERM_N; FERM N-terminal domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394572.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    125676..168348
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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