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TMSB15B thymosin beta 15B [ Homo sapiens (human) ]

Gene ID: 286527, updated on 14-Nov-2024

Summary

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Official Symbol
TMSB15Bprovided by HGNC
Official Full Name
thymosin beta 15Bprovided by HGNC
Primary source
HGNC:HGNC:28612
See related
Ensembl:ENSG00000158427 MIM:301011; AllianceGenome:HGNC:28612
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TMSL8; TMSNB; TMSB15A; Tbeta15b
Summary
Predicted to enable actin monomer binding activity. Involved in positive regulation of cell migration. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in ovary (RPKM 5.0), endometrium (RPKM 4.8) and 22 other tissues See more
Orthologs
all
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Genomic context

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See TMSB15B in Genome Data Viewer
Location:
Xq22.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (103919155..103974426)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (102360190..102415483)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (103173738..103229008)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene TMSB15B antisense RNA 1 Neighboring gene H2B histone pseudogene 9 Neighboring gene ELF2 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29824 Neighboring gene SLC25A53 pseudogene 1 Neighboring gene DPPA3 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:103238205-103238704 Neighboring gene uncharacterized LOC107987334 Neighboring gene H2B.W histone 4, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Thymosin beta-NB is the human isoform of rat thymosin beta15. Banyard J, et al. Ann N Y Acad Sci, 2007 Sep. PMID 17567946
  2. Differential regulation of human thymosin beta 15 isoforms by transforming growth factor beta 1. Banyard J, et al. Genes Chromosomes Cancer, 2009 Jun. PMID 19296525, Free PMC Article
  3. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. Gevaert K, et al. Nat Biotechnol, 2003 May. PMID 12665801
  4. The DNA sequence of the human X chromosome. Ross MT, et al. Nature, 2005 Mar 17. PMID 15772651, Free PMC Article
  5. SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity. Shi P, et al. J Immunol, 2020 Jul 1. PMID 32393512

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: H2BW4P

Homology

Clone Names

  • MGC39900

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin monomer binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sequestering of actin monomers IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
thymosin beta-15B
Names
NB thymosin beta
Thymosin beta-15A
Thymosin-like protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001350211.2 → NP_001337140.1  thymosin beta-15B isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and contains a longer 5' UTR compared to variant 1.
    Source sequence(s)
    BC019900
    Consensus CDS
    CCDS59172.1
    UniProtKB/Swiss-Prot
    A8K614, P0CG34, P0CG35, P0DX04, Q99406
    Related
    ENSP00000456121.1, ENST00000419165.5
    Conserved Domains (1) summary
    pfam01290
    Location:3 → 39
    Thymosin; Thymosin beta-4 family

  2. NM_001350212.2 → NP_001337141.1  thymosin beta-15B isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon in the 5' UTR compared to variant 1.
    Source sequence(s)
    AC234782, BQ011701, CN271772
    Consensus CDS
    CCDS59172.1
    UniProtKB/Swiss-Prot
    A8K614, P0CG34, P0CG35, P0DX04, Q99406
    Related
    ENSP00000457057.1, ENST00000569577.1
    Conserved Domains (1) summary
    pfam01290
    Location:3 → 39
    Thymosin; Thymosin beta-4 family

  3. NM_001350213.2 → NP_001337142.1  thymosin beta-15B isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents use of an alternate promoter and differs in both the 5' and 3' exon structure compared to variant 1. The encoded isoform (2) has a longer, distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC234782
    UniProtKB/TrEMBL
    A0A087X1C1
    Conserved Domains (1) summary
    pfam01290
    Location:3 → 33
    Thymosin; Thymosin beta-4 family

  4. NM_194324.4 → NP_919305.2  thymosin beta-15B isoform 1

    See identical proteins and their annotated locations for NP_919305.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the canonical isoform (1).
    Source sequence(s)
    BC093093, BQ011701
    Consensus CDS
    CCDS59172.1
    UniProtKB/Swiss-Prot
    A8K614, P0CG34, P0CG35, P0DX04, Q99406
    Related
    ENSP00000455371.1, ENST00000540220.6
    Conserved Domains (1) summary
    pfam01290
    Location:3 → 39
    Thymosin; Thymosin beta-4 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    103919155..103974426
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    102360190..102415483
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0CG35.1 GenPept UniProtKB/Swiss-Prot:P0CG35

Gene LinkOut

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Chemical Information
Molecular Biology Databases
Research Materials