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FAM133A family with sequence similarity 133 member A [ Homo sapiens (human) ]

Gene ID: 286499, updated on 27-Aug-2024

Summary

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Official Symbol
FAM133Aprovided by HGNC
Official Full Name
family with sequence similarity 133 member Aprovided by HGNC
Primary source
HGNC:HGNC:26748
See related
Ensembl:ENSG00000179083 AllianceGenome:HGNC:26748
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT115
Expression
Biased expression in testis (RPKM 2.8), brain (RPKM 1.0) and 2 other tissues See more
Orthologs
all
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Genomic context

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Location:
Xq21.32
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (93673681..93712265)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (92118892..92157407)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (92929205..92967264)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chrX:92840114-92841313 Neighboring gene ribosomal protein L7 pseudogene 55 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:92882347-92882848 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:92891704-92892690 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:92892691-92893676 Neighboring gene nucleosome assembly protein 1 like 3 Neighboring gene USP37 pseudogene 1 Neighboring gene RNA, U6 small nuclear 332, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Folate receptor α increases chemotherapy resistance through stabilizing MDM2 in cooperation with PHB2 that is overcome by MORAb-202 in gastric cancer. Sakai H, et al. Clin Transl Med, 2021 Jun. PMID 34185411, Free PMC Article
  2. Histone-binding of DPF2 mediates its repressive role in myeloid differentiation. Huber FM, et al. Proc Natl Acad Sci U S A, 2017 Jun 6. PMID 28533407, Free PMC Article
  3. Pooled-matrix protein interaction screens using Barcode Fusion Genetics. Yachie N, et al. Mol Syst Biol, 2016 Apr 22. PMID 27107012, Free PMC Article
  4. A protein interaction landscape of breast cancer. Kim M, et al. Science, 2021 Oct. PMID 34591612, Free PMC Article
  5. HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation. Yuan J, et al. Cell Mol Gastroenterol Hepatol, 2023. PMID 36244648, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ37659

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
protein FAM133A
Names
cancer/testis antigen 115

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016400.1 RefSeqGene

    Range
    5194..43253
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001171109.2 → NP_001164580.1  protein FAM133A

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AL009173, DA414074
    Consensus CDS
    CCDS14466.1
    UniProtKB/Swiss-Prot
    Q8N9E0
    Related
    ENSP00000507109.1, ENST00000683942.1

  2. NM_001171110.2 → NP_001164581.1  protein FAM133A

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AL009173, DA188870
    Consensus CDS
    CCDS14466.1
    UniProtKB/Swiss-Prot
    Q8N9E0

  3. NM_001171111.2 → NP_001164582.1  protein FAM133A

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AL009173, DB084469
    Consensus CDS
    CCDS14466.1
    UniProtKB/Swiss-Prot
    Q8N9E0
    Related
    ENSP00000318974.4, ENST00000322139.4

  4. NM_173698.3 → NP_775969.1  protein FAM133A

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AL009173, DA297338
    Consensus CDS
    CCDS14466.1
    UniProtKB/Swiss-Prot
    Q8N9E0
    Related
    ENSP00000362169.1, ENST00000332647.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    93673681..93712265
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530926.4 → XP_011529228.1  protein FAM133A isoform X1

    UniProtKB/Swiss-Prot
    Q8N9E0

  2. XM_011530927.3 → XP_011529229.1  protein FAM133A isoform X1

    UniProtKB/Swiss-Prot
    Q8N9E0

  3. XM_011530929.2 → XP_011529231.1  protein FAM133A isoform X1

    UniProtKB/Swiss-Prot
    Q8N9E0

  4. XM_017029454.2 → XP_016884943.1  protein FAM133A isoform X1

    UniProtKB/Swiss-Prot
    Q8N9E0

  5. XM_017029455.2 → XP_016884944.1  protein FAM133A isoform X1

    UniProtKB/Swiss-Prot
    Q8N9E0

  6. XM_011530928.2 → XP_011529230.1  protein FAM133A isoform X1

    UniProtKB/Swiss-Prot
    Q8N9E0

  7. XM_011530925.3 → XP_011529227.1  protein FAM133A isoform X1

    UniProtKB/Swiss-Prot
    Q8N9E0

  8. XM_017029456.2 → XP_016884945.1  protein FAM133A isoform X1

    UniProtKB/Swiss-Prot
    Q8N9E0

  9. XM_006724641.4 → XP_006724704.1  protein FAM133A isoform X1

    UniProtKB/Swiss-Prot
    Q8N9E0

  10. XM_011530931.3 → XP_011529233.1  protein FAM133A isoform X1

    UniProtKB/Swiss-Prot
    Q8N9E0

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    92118892..92157407
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054326903.1 → XP_054182878.1  protein FAM133A isoform X1

    UniProtKB/Swiss-Prot
    Q8N9E0

  2. XM_054326902.1 → XP_054182877.1  protein FAM133A isoform X1

    UniProtKB/Swiss-Prot
    Q8N9E0

  3. XM_054326910.1 → XP_054182885.1  protein FAM133A isoform X1

    UniProtKB/Swiss-Prot
    Q8N9E0

  4. XM_054326909.1 → XP_054182884.1  protein FAM133A isoform X1

    UniProtKB/Swiss-Prot
    Q8N9E0

  5. XM_054326906.1 → XP_054182881.1  protein FAM133A isoform X1

    UniProtKB/Swiss-Prot
    Q8N9E0

  6. XM_054326908.1 → XP_054182883.1  protein FAM133A isoform X1

    UniProtKB/Swiss-Prot
    Q8N9E0

  7. XM_054326904.1 → XP_054182879.1  protein FAM133A isoform X1

    UniProtKB/Swiss-Prot
    Q8N9E0

  8. XM_054326907.1 → XP_054182882.1  protein FAM133A isoform X1

    UniProtKB/Swiss-Prot
    Q8N9E0

  9. XM_054326905.1 → XP_054182880.1  protein FAM133A isoform X1

    UniProtKB/Swiss-Prot
    Q8N9E0

  10. XM_054326911.1 → XP_054182886.1  protein FAM133A isoform X1

    UniProtKB/Swiss-Prot
    Q8N9E0
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N9E0.1 GenPept UniProtKB/Swiss-Prot:Q8N9E0

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