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SCAI suppressor of cancer cell invasion [ Homo sapiens (human) ]

Gene ID: 286205, updated on 5-Mar-2024

Summary

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Official Symbol
SCAIprovided by HGNC
Official Full Name
suppressor of cancer cell invasionprovided by HGNC
Primary source
HGNC:HGNC:26709
See related
Ensembl:ENSG00000173611 MIM:619222; AllianceGenome:HGNC:26709
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NET40; C9orf126
Summary
This gene encodes a regulator of cell migration. The encoded protein appears to function in the RhoA (ras homolog gene family, member A)-Dia1 (diaphanous homolog 1) signal transduction pathway. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]
Expression
Ubiquitous expression in brain (RPKM 4.6), lung (RPKM 2.0) and 24 other tissues See more
Orthologs
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Genomic context

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Location:
9q33.3
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (124942608..125143528, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (137140969..137341870, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (127704887..127905807, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:127623737-127624360 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28993 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28994 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20270 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20271 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28995 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28996 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127634813-127635313 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:127643063-127643616 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:127646402-127646543 Neighboring gene actin related protein 2/3 complex subunit 5 like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:127662503-127663016 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:127665639-127666139 Neighboring gene RNA, U4 small nuclear 82, pseudogene Neighboring gene golgin A1 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:127681363-127681624 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:127702954-127703454 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:127703455-127703955 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28998 Neighboring gene NANOG hESC enhancer GRCh37_chr9:127737373-127737931 Neighboring gene frataxin pseudogene 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:127806191-127806703 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127806704-127807217 Neighboring gene uncharacterized LOC124902355 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20274 Neighboring gene phosphoribosyl pyrophosphate synthetase 1 pseudogene 2 Neighboring gene protein phosphatase 6 catalytic subunit Neighboring gene NADH:ubiquinone oxidoreductase subunit B3 pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Alterations in SCAI Expression during Cell Plasticity, Fibrosis and Cancer. Gasparics Á, et al. Pathol Oncol Res, 2018 Jul. PMID 28815470
  2. Bridging Gaps in HDR Improvement: The Role of MAD2L2, SCAI, and SCR7. Anuchina AA, et al. Int J Mol Sci, 2023 Apr 4. PMID 37047677, Free PMC Article
  3. Inhibition of Microrna-766-5p Attenuates the Development of Cervical Cancer Through Regulating SCAI. Cai Y, et al. Technol Cancer Res Treat, 2020 Jan-Dec. PMID 33327889, Free PMC Article
  4. miR-371b-5p promotes cell proliferation, migration and invasion in non-small cell lung cancer via SCAI. Luo X, et al. Biosci Rep, 2020 Nov 27. PMID 33103723, Free PMC Article
  5. Mir-5100 Mediates Proliferation, Migration and Invasion of Oral Squamous Cell Carcinoma Cells Via Targeting SCAI. Wei Z, et al. J Invest Surg, 2021 Aug. PMID 31851859

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hsa_circ_0052611 and mir-767-5p guide the warburg effect, migration, and invasion of BRCA cells through modulating SCAI.
    Title: Hsa_circ_0052611 and mir-767-5p guide the warburg effect, migration, and invasion of BRCA cells through modulating SCAI.
  2. Bridging Gaps in HDR Improvement: The Role of MAD2L2, SCAI, and SCR7.
    Title: Bridging Gaps in HDR Improvement: The Role of MAD2L2, SCAI, and SCR7.
  3. The Protexin complex counters resection on stalled forks to promote homologous recombination and crosslink repair.
    Title: The Protexin complex counters resection on stalled forks to promote homologous recombination and crosslink repair.
  4. Inhibition of Microrna-766-5p Attenuates the Development of Cervical Cancer Through Regulating SCAI.
    Title: Inhibition of Microrna-766-5p Attenuates the Development of Cervical Cancer Through Regulating SCAI.
  5. Mir-5100 Mediates Proliferation, Migration and Invasion of Oral Squamous Cell Carcinoma Cells Via Targeting SCAI.
    Title: Mir-5100 Mediates Proliferation, Migration and Invasion of Oral Squamous Cell Carcinoma Cells Via Targeting SCAI.
  6. miR-371b-5p promotes cell proliferation, migration and invasion in non-small cell lung cancer via SCAI.
    Title: miR-371b-5p promotes cell proliferation, migration and invasion in non-small cell lung cancer via SCAI.
  7. MicroRNA-625-3p was highly expressed in oral squamous cell carcinoma (OSCC) tissues. OSCC patients with T3+T4 stage had higher expression of microRNA-625-3p than those with T1+T2 stage. SCAI was identified as a target gene of microRNA-625-3p. ROC curve showed that microRNA-625-3p and SCAI exert certain values in diagnosing OSCC. MicroRNA-625-3p promoted migration of OSCC cells, which was reversed by SCAI knockdown.
    Title: MicroRNA-625-3p promotes cell migration of oral squamous cell carcinoma by regulating SCAI expression.
  8. This study provides evidence that CAF exosomal miR-1228 is able to promote osteosarcoma invasion and migration by targeting SCAI.
    Title: Exosomal miR-1228 From Cancer-Associated Fibroblasts Promotes Cell Migration and Invasion of Osteosarcoma by Directly Targeting SCAI.
  9. SCAI binds to miR-1270 which inversely regulates SCAI gene expression in papillary thyroid cancer cells.
    Title: MicroRNA-1270 modulates papillary thyroid cancer cell development by regulating SCAI.
  10. High SCAI expression is associated with gastric, prostate, and colorectal cancer.
    Title: Alterations in SCAI Expression during Cell Plasticity, Fibrosis and Cancer.
Submit: New GeneRIF Correction See all GeneRIFs (19)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ11758, FLJ36664, MGC120525, MGC120526, MGC120528

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of Rho protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein SCAI
Names
suppressor of cancer cell invasion protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016620.1 RefSeqGene

    Range
    5032..205952
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001144877.3 → NP_001138349.1  protein SCAI isoform 2

    See identical proteins and their annotated locations for NP_001138349.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL451125, BC104031, BM873972, DB048788
    Consensus CDS
    CCDS48017.1
    UniProtKB/Swiss-Prot
    Q3SXZ1, Q3SXZ2, Q5T163, Q8N1I4, Q8N9R8
    Related
    ENSP00000336756.6, ENST00000336505.11
    Conserved Domains (1) summary
    pfam12070
    Location:64 → 557
    SCAI; Protein SCAI

  2. NM_173690.5 → NP_775961.2  protein SCAI isoform 1

    See identical proteins and their annotated locations for NP_775961.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL451125, BC104030, BM873972, DB048788
    Consensus CDS
    CCDS43877.1
    UniProtKB/Swiss-Prot
    Q8N9R8
    Related
    ENSP00000362650.4, ENST00000373549.8
    Conserved Domains (1) summary
    pfam12070
    Location:87 → 580
    SCAI; Protein SCAI

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    124942608..125143528 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_007061282.1 RNA Sequence

  2. XR_007061281.1 RNA Sequence

  3. XR_007061283.1 RNA Sequence

  4. XR_929768.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    137140969..137341870 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_008487985.1 RNA Sequence

  2. XR_008487984.1 RNA Sequence

  3. XR_008487987.1 RNA Sequence

  4. XR_008487986.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N9R8.2 GenPept UniProtKB/Swiss-Prot:Q8N9R8

Gene LinkOut

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