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PPP1R42 protein phosphatase 1 regulatory subunit 42 [ Homo sapiens (human) ]

Gene ID: 286187, updated on 5-Mar-2024

Summary

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Official Symbol
PPP1R42provided by HGNC
Official Full Name
protein phosphatase 1 regulatory subunit 42provided by HGNC
Primary source
HGNC:HGNC:33732
See related
Ensembl:ENSG00000178125 MIM:617720; AllianceGenome:HGNC:33732
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
dtr; TLLR; TLRR; LRRC67
Summary
The protein encoded by this gene can interact with gamma-tubulin and PP1 phosphatase, a regulator of centrosome separation. The encoded protein is a positive regulator of PP1 phosphatase and thus plays a role in the control of centrosome integrity. [provided by RefSeq, Feb 2017]
Expression
Restricted expression toward testis (RPKM 6.0) See more
Orthologs
mouse all
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Genomic context

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See PPP1R42 in Genome Data Viewer
Location:
8q13.1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (66964103..67028554, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (67390584..67455035, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (67876338..67940789, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene minichromosome maintenance domain containing 2 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:67837556-67838755 Neighboring gene small nucleolar RNA, C/D box 87 Neighboring gene small nucleolar RNA host gene 6 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:67852931-67853432 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:67867090-67867662 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19259 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27493 Neighboring gene transcription factor 24 Neighboring gene pre-mRNA processing factor 3 pseudogene Neighboring gene uncharacterized LOC124902097 Neighboring gene uncharacterized LOC105375885 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27494 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27495 Neighboring gene COP9 signalosome subunit 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. PPP1R42, a PP1 binding protein, regulates centrosome dynamics in ARPE-19 cells. DeVaul N, et al. Biol Cell, 2013 Aug. PMID 23718219, Free PMC Article
  2. Genome-scale RNAi screen for host factors required for HIV replication. Zhou H, et al. Cell Host Microbe, 2008 Nov 13. PMID 18976975
  3. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Fasci D, et al. Mol Cell Proteomics, 2018 Oct. PMID 30021884, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PPP1R42 regulation of PP1 function in centrosome separation.
    Title: PPP1R42, a PP1 binding protein, regulates centrosome dynamics in ARPE-19 cells.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of protein phosphatase 1, regulatory subunit 42 (PPP1R42) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Potential readthrough

Included gene: COPS5

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables dynein complex binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables tubulin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in centrosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in manchette ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in microtubule cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in microtubule organizing center ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
protein phosphatase 1 regulatory subunit 42
Names
leucine rich repeat containing 67
leucine-rich repeat-containing protein 67
testis leucine-rich repeat

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013626.4 → NP_001013648.1  protein phosphatase 1 regulatory subunit 42 isoform 1

    See identical proteins and their annotated locations for NP_001013648.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC110998, BC055413, BU678298
    Consensus CDS
    CCDS34902.1
    UniProtKB/Swiss-Prot
    Q7Z4L9
    Related
    ENSP00000315035.5, ENST00000324682.5
    Conserved Domains (3) summary
    COG4886
    Location:28 → 162
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:31 → 51
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:72 → 114
    LRR_4; Leucine Rich repeats (2 copies)

  2. NM_001348563.2 → NP_001335492.1  protein phosphatase 1 regulatory subunit 42 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' and 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has shorter and distinct N- and C-termini compared to isoform 1.
    Source sequence(s)
    AC110998, BC055413, BX104552
    UniProtKB/Swiss-Prot
    Q7Z4L9
    Related
    ENST00000520633.1

  3. NM_001364910.1 → NP_001351839.1  protein phosphatase 1 regulatory subunit 42 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC110998
    Consensus CDS
    CCDS94299.1
    UniProtKB/Swiss-Prot
    G3V118, Q7Z4L9
    UniProtKB/TrEMBL
    A0A8I5KP60
    Related
    ENSP00000508980.1, ENST00000685739.1
    Conserved Domains (2) summary
    sd00033
    Location:31 → 51
    LRR_RI; leucine-rich repeat [structural motif]
    pfam14580
    Location:1 → 104
    LRR_9; Leucine-rich repeat

  4. NM_001364911.2 → NP_001351840.1  protein phosphatase 1 regulatory subunit 42 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC110998
    Conserved Domains (1) summary
    pfam14580
    Location:61 → 154
    LRR_9; Leucine-rich repeat

  5. NM_001364912.2 → NP_001351841.1  protein phosphatase 1 regulatory subunit 42 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC110998
    Conserved Domains (2) summary
    sd00033
    Location:31 → 51
    LRR_RI; leucine-rich repeat [structural motif]
    pfam14580
    Location:1 → 104
    LRR_9; Leucine-rich repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    66964103..67028554 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    67390584..67455035 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7Z4L9.3 GenPept UniProtKB/Swiss-Prot:Q7Z4L9

Gene LinkOut

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