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ZNF707 zinc finger protein 707 [ Homo sapiens (human) ]

Gene ID: 286075, updated on 2-Nov-2024

Summary

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Official Symbol
ZNF707provided by HGNC
Official Full Name
zinc finger protein 707provided by HGNC
Primary source
HGNC:HGNC:27815
See related
Ensembl:ENSG00000181135 AllianceGenome:HGNC:27815
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis (RPKM 4.1), spleen (RPKM 3.7) and 25 other tissues See more
Orthologs
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Genomic context

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See ZNF707 in Genome Data Viewer
Location:
8q24.3
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (143684479..143695385)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (144840870..144851771)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (144766649..144777555)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene zinc finger protein 623 Neighboring gene U7 small nuclear RNA Neighboring gene uncharacterized LOC105375799 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:144751216-144751716 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:144751717-144752217 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:144764224-144764449 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:144781964-144782464 Neighboring gene long intergenic non-protein coding RNA 2878 Neighboring gene uncharacterized LOC101928160 Neighboring gene coiled-coil domain containing 166

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Human ORFeome version 1.1: a platform for reverse proteomics. Rual JF, et al. Genome Res, 2004 Oct. PMID 15489335, Free PMC Article
  2. BRCA2 mediates centrosome cohesion via an interaction with cytoplasmic dynein. Malik S, et al. Cell Cycle, 2016 Aug 17. PMID 27433848, Free PMC Article
  3. UBE2O and USP7 co-regulate RECQL4 ubiquitinylation and homologous recombination-mediated DNA repair. Huang Q, et al. FASEB J, 2022 Jan. PMID 34921745
  4. Shifted Transversal Design smart-pooling for high coverage interactome mapping. Xin X, et al. Genome Res, 2009 Jul. PMID 19447967, Free PMC Article
  5. Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells. Chang YJ, et al. Int J Mol Sci, 2023 Jun 6. PMID 37372979, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 707

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100598.2 → NP_001094068.1  zinc finger protein 707 isoform a

    See identical proteins and their annotated locations for NP_001094068.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 4. Variants 1, 2, 3, 4, and 5 encode the same protein (isoform a).
    Source sequence(s)
    AK001126, AK055263, AW294133, BC014894, CV023324, DA007942, DB249556
    Consensus CDS
    CCDS47932.1
    UniProtKB/Swiss-Prot
    A8K317, B3KNY1, D3DWK7, Q96C28
    Related
    ENSP00000351482.4, ENST00000358656.9
    Conserved Domains (6) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:187 → 366
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:262 → 282
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:260 → 282
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:8 → 47
    KRAB; KRAB box
    pfam13465
    Location:218 → 242
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001100599.2 → NP_001094069.1  zinc finger protein 707 isoform a

    See identical proteins and their annotated locations for NP_001094069.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 4. Variants 1, 2, 3, 4, and 5 encode the same protein (isoform a).
    Source sequence(s)
    AK001126, AK055263, AW294133, BC014894, CV023324, DA917297, DB249556
    Consensus CDS
    CCDS47932.1
    UniProtKB/Swiss-Prot
    A8K317, B3KNY1, D3DWK7, Q96C28
    Conserved Domains (6) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:187 → 366
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:262 → 282
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:260 → 282
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:8 → 47
    KRAB; KRAB box
    pfam13465
    Location:218 → 242
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001288805.2 → NP_001275734.1  zinc finger protein 707 isoform a

    See identical proteins and their annotated locations for NP_001275734.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes isoform a. Variants 1, 2, 3, 4, and 5 encode the same protein (isoform a).
    Source sequence(s)
    AC105219, AK095138, AK290432, AW294133, DB249556
    Consensus CDS
    CCDS47932.1
    UniProtKB/Swiss-Prot
    A8K317, B3KNY1, D3DWK7, Q96C28
    Related
    ENSP00000436212.1, ENST00000532205.5
    Conserved Domains (6) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:187 → 366
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:262 → 282
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:260 → 282
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:8 → 47
    KRAB; KRAB box
    pfam13465
    Location:218 → 242
    zf-H2C2_2; Zinc-finger double domain

  4. NM_001288806.2 → NP_001275735.1  zinc finger protein 707 isoform a

    See identical proteins and their annotated locations for NP_001275735.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 4. Variants 1, 2, 3, 4, and 5 encode the same protein (isoform a).
    Source sequence(s)
    AC105219, AK290432, AW294133, DA188478, DA990503
    Consensus CDS
    CCDS47932.1
    UniProtKB/Swiss-Prot
    A8K317, B3KNY1, D3DWK7, Q96C28
    Conserved Domains (6) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:187 → 366
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:262 → 282
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:260 → 282
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:8 → 47
    KRAB; KRAB box
    pfam13465
    Location:218 → 242
    zf-H2C2_2; Zinc-finger double domain

  5. NM_001288807.2 → NP_001275736.1  zinc finger protein 707 isoform b

    See identical proteins and their annotated locations for NP_001275736.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon in an alternate exon, compared to variant 4. This results in a shorter protein (isoform b), compared to isoform a.
    Source sequence(s)
    AC105219, AK290432, AW294133, DA957023, DB249556
    UniProtKB/Swiss-Prot
    Q96C28
    Conserved Domains (4) summary
    COG5048
    Location:95 → 262
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:189 → 209
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:187 → 209
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:145 → 169
    zf-H2C2_2; Zinc-finger double domain

  6. NM_001288808.2 → NP_001275737.1  zinc finger protein 707 isoform c

    See identical proteins and their annotated locations for NP_001275737.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 4. This results in a shorter protein (isoform c), compared to isoform a. Variants 7 and 8 encode the same protein (isoform c).
    Source sequence(s)
    AC105219, AK290432, AW294133, DA188478, DB106612
    UniProtKB/Swiss-Prot
    Q96C28
    Conserved Domains (5) summary
    smart00349
    Location:1 → 32
    KRAB; krueppel associated box
    COG5048
    Location:151 → 330
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:226 → 246
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:224 → 246
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:182 → 206
    zf-H2C2_2; Zinc-finger double domain

  7. NM_001288809.2 → NP_001275738.1  zinc finger protein 707 isoform c

    See identical proteins and their annotated locations for NP_001275738.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 4. This results in a shorter protein (isoform c), compared to isoform a. Variants 7 and 8 encode the same protein (isoform c).
    Source sequence(s)
    AC105219, AK001126, AK290432, AW294133, DA188478, DB125792
    UniProtKB/Swiss-Prot
    Q96C28
    Conserved Domains (5) summary
    smart00349
    Location:1 → 32
    KRAB; krueppel associated box
    COG5048
    Location:151 → 330
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:226 → 246
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:224 → 246
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:182 → 206
    zf-H2C2_2; Zinc-finger double domain

  8. NM_173831.4 → NP_776192.2  zinc finger protein 707 isoform a

    See identical proteins and their annotated locations for NP_776192.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 4. Variants 1, 2, 3, 4, and 5 encode the same protein (isoform a).
    Source sequence(s)
    AK001126, AK055263, AW294133, BC014894, CV023324, DB249556
    Consensus CDS
    CCDS47932.1
    UniProtKB/Swiss-Prot
    A8K317, B3KNY1, D3DWK7, Q96C28
    Related
    ENSP00000436250.1, ENST00000532158.5
    Conserved Domains (6) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:187 → 366
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:262 → 282
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:260 → 282
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:8 → 47
    KRAB; KRAB box
    pfam13465
    Location:218 → 242
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_110190.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) lacks multiple 5' exons and uses an alternate 3' splice site, compared to variant 4. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC105219, AK001126, AK290432, AW294133, DB249556
    Related
    ENST00000533031.5

  2. NR_110191.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) differs in its 5' exon structure and uses an alternate 3' splice site, compared to variant 4. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC105219, AK290432, AW294133, DB099015

  3. NR_110192.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) differs in its 5' exon structure and uses an alternate 3' splice sites, compared to variant 4. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC105219, AK001126, AK290432, AW294133, DA188478

  4. NR_110193.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) differs in its 5' exon structure and uses an alternate 3' splice site, compared to variant 4. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC105219, AK001126, AK290432, AW294133, DA555314

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    143684479..143695385
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187571.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    161526..172432
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    144840870..144851771
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96C28.2 GenPept UniProtKB/Swiss-Prot:Q96C28

Gene LinkOut

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