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DLX6-AS1 DLX6 antisense RNA 1 [ Homo sapiens (human) ]

Gene ID: 285987, updated on 10-Oct-2023

Summary

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Official Symbol
DLX6-AS1provided by HGNC
Official Full Name
DLX6 antisense RNA 1provided by HGNC
Primary source
HGNC:HGNC:37151
See related
AllianceGenome:HGNC:37151
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Evf-2; DLX6AS; DLX6-AS; NCRNA00212
Summary
Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
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Genomic context

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Location:
7q21.3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (96968515..97014065, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (98198163..98243721, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (96597827..96643377, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene 5K-Del enhancer in SHFM1 region Neighboring gene uncharacterized LOC124901703 Neighboring gene RNA, 7SL, cytoplasmic 252, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:96621779-96622304 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:96622305-96622831 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:96627585-96628528 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:96630843-96631552 Neighboring gene VISTA enhancer hs298 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18385 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:96650255-96651454 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:96653649-96654365 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:96655292-96655807 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26299 Neighboring gene distal-less homeobox 6 Neighboring gene distal-less homeobox 5 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:96727665-96727870 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26300 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26301 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:96763667-96763818 Neighboring gene succinate dehydrogenase complex assembly factor 3 Neighboring gene high mobility group box 3 pseudogene 21

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. DLX6-AS1: a putative lncRNA candidate in multiple human cancers. Sheykhhasan M, et al. Expert Rev Mol Med, 2021 Nov 26. PMID 34823630
  2. DLX6-AS1 is a potential biomarker and therapeutic target in cancer initiation and progression. Zheng Q, et al. Clin Chim Acta, 2021 Jun. PMID 33607068
  3. Serum Exosomal lncRNA DLX6-AS1 Is a Promising Biomarker for Prognosis Prediction of Cervical Cancer. Ding XZ, et al. Technol Cancer Res Treat, 2021 Jan-Dec. PMID 33550924, Free PMC Article
  4. DLX6-AS1 accelerates cell proliferation through regulating miR-497-5p/SNCG pathway in prostate cancer. Zhu X, et al. Environ Toxicol, 2021 Mar. PMID 33035382
  5. Silencing of long non-coding RNA DLX6-AS1 weakens neuroblastoma progression by the miR-513c-5p/PLK4 axis. Jia P, et al. IUBMB Life, 2020 Dec. PMID 33031637

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A Peptide Encoded by a Long Non-Coding RNA DLX6-AS1 Facilitates Cell Proliferation, Migration, and Invasion by Activating the wnt/beta-Catenin Signaling Pathway in Non-Small-Cell Lung Cancer Cell.
    Title: A Peptide Encoded by a Long Non-Coding RNA DLX6-AS1 Facilitates Cell Proliferation, Migration, and Invasion by Activating the wnt/β-Catenin Signaling Pathway in Non-Small-Cell Lung Cancer Cell.
  2. cAMP-response element binding protein mediates podocyte injury in diabetic nephropathy by targeting lncRNA DLX6-AS1.
    Title: cAMP-response element binding protein mediates podocyte injury in diabetic nephropathy by targeting lncRNA DLX6-AS1.
  3. Silencing long non-coding RNA DLX6-AS1 or restoring microRNA-193b-3p enhances thyroid carcinoma cell autophagy and apoptosis via depressing HOXA1.
    Title: Silencing long non-coding RNA DLX6-AS1 or restoring microRNA-193b-3p enhances thyroid carcinoma cell autophagy and apoptosis via depressing HOXA1.
  4. Upregulated lncRNA DLX6-AS1 underpins hepatocellular carcinoma progression via the miR-513c/Cul4A/ANXA10 axis.
    Title: Upregulated lncRNA DLX6-AS1 underpins hepatocellular carcinoma progression via the miR-513c/Cul4A/ANXA10 axis.
  5. DLX6-AS1: a putative lncRNA candidate in multiple human cancers.
    Title: DLX6-AS1: a putative lncRNA candidate in multiple human cancers.
  6. DLX6-AS1 activated by H3K4me1 enhanced secondary cisplatin resistance of lung squamous cell carcinoma through modulating miR-181a-5p/miR-382-5p/CELF1 axis.
    Title: DLX6-AS1 activated by H3K4me1 enhanced secondary cisplatin resistance of lung squamous cell carcinoma through modulating miR-181a-5p/miR-382-5p/CELF1 axis.
  7. Serum Exosomal lncRNA DLX6-AS1 Is a Promising Biomarker for Prognosis Prediction of Cervical Cancer.
    Title: Serum Exosomal lncRNA DLX6-AS1 Is a Promising Biomarker for Prognosis Prediction of Cervical Cancer.
  8. Silencing of long non-coding RNA DLX6-AS1 weakens neuroblastoma progression by the miR-513c-5p/PLK4 axis.
    Title: Silencing of long non-coding RNA DLX6-AS1 weakens neuroblastoma progression by the miR-513c-5p/PLK4 axis.
  9. DLX6-AS1 is a potential biomarker and therapeutic target in cancer initiation and progression.
    Title: DLX6-AS1 is a potential biomarker and therapeutic target in cancer initiation and progression.
  10. Knockdown of LncRNA DLX6-AS1 inhibits HK-2 cell pyroptosis via regulating miR-223-3p/NLRP3 pathway in lipopolysaccharide-induced acute kidney injury.
    Title: Knockdown of LncRNA DLX6-AS1 inhibits HK-2 cell pyroptosis via regulating miR-223-3p/NLRP3 pathway in lipopolysaccharide-induced acute kidney injury.
Submit: New GeneRIF Correction See all GeneRIFs (26)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study identifies susceptibility loci for ossification of the posterior longitudinal ligament of the spine.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Other Names

  • DLX6 antisense RNA (non-protein coding)
  • DLX6 antisense RNA 1 (non-protein coding)

Clone Names

  • FLJ34048

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_015448.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC004774, AK095619, BE263812

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    96968515..97014065 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    98198163..98243721 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Chemical Information
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Research Materials