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SNHG15 small nucleolar RNA host gene 15 [ Homo sapiens (human) ]

Gene ID: 285958, updated on 2-Nov-2024

Summary

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Official Symbol
SNHG15provided by HGNC
Official Full Name
small nucleolar RNA host gene 15provided by HGNC
Primary source
HGNC:HGNC:27797
See related
Ensembl:ENSG00000232956 AllianceGenome:HGNC:27797
Gene type
ncRNA
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C7orf40; MYO1GUT; Linc-Myo1g
Summary
This gene represents a snoRNA host gene that produces a short-lived long non-coding RNA. This non-coding RNA is upregulated in tumor cells and may contribute to cell proliferation by acting as a sponge for microRNAs. [provided by RefSeq, Dec 2017]
Expression
Ubiquitous expression in bone marrow (RPKM 27.7), ovary (RPKM 10.8) and 24 other tissues See more
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Genomic context

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See SNHG15 in Genome Data Viewer
Location:
7p13
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (44983023..44986696, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (45143371..45147061, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (45022622..45026295, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S23 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44995675-44996176 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:45001789-45002289 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25958 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18159 Neighboring gene myosin IG Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18160 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25959 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25960 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25961 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:45024687-45024867 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:45025394-45026140 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:45026141-45026888 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:45030540-45031094 Neighboring gene uncharacterized LOC102723334 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25963 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25964 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25965 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25966 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18161 Neighboring gene small nucleolar RNA, H/ACA box 9 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18162 Neighboring gene CCM2 scaffold protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18163 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25967 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25968 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:45112087-45112746 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:45112747-45113406 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_99227 Neighboring gene NAC alpha domain containing

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. SNHG15 promotes gallbladder cancer progression by enhancing the autophagy of tumor cell under nutrition stress. Min H, et al. Cell Cycle, 2023 Oct. PMID 37937948,
  2. Long non-coding RNA SNHG15 indicates poor prognosis of non-small cell lung cancer and promotes cell proliferation and invasion. Dong YZ, et al. Eur Rev Med Pharmacol Sci, 2018 May. PMID 29771418
  3. Evaluating the diagnostic and prognostic value of long non-coding RNA SNHG15 in pancreatic ductal adenocarcinoma. Guo XB, et al. Eur Rev Med Pharmacol Sci, 2018 Sep. PMID 30280769
  4. Aberrant expression of long noncoding RNA SNHG15 correlates with liver metastasis and poor survival in colorectal cancer. Huang L, et al. J Cell Physiol, 2019 May. PMID 30317592
  5. LncRNA SNHG15 promotes proliferation and migration of lung cancer via targeting microRNA-211-3p. Cui HX, et al. Eur Rev Med Pharmacol Sci, 2018 Oct. PMID 30402848

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Uncovering the relationship between YAP/ WWTR1 (TAZ) genes expression and LncRNAs of SNHG15, HCP5 and LINC01433 in breast cancer tissues.
    Title: Uncovering the relationship between YAP/ WWTR1 (TAZ) genes expression and LncRNAs of SNHG15, HCP5 and LINC01433 in breast cancer tissues.
  2. SNHG15 promotes gallbladder cancer progression by enhancing the autophagy of tumor cell under nutrition stress.
    Title: SNHG15 promotes gallbladder cancer progression by enhancing the autophagy of tumor cell under nutrition stress.
  3. SNHG15 promotes chemoresistance and glycolysis in colorectal cancer.
    Title: SNHG15 promotes chemoresistance and glycolysis in colorectal cancer.
  4. LncRNA SNHG15 Modulates Ischemia-Reperfusion Injury in Human AC16 Cardiomyocytes Depending on the Regulation of the miR-335-3p/TLR4/NF-kappaB Pathway.
    Title: LncRNA SNHG15 Modulates Ischemia-Reperfusion Injury in Human AC16 Cardiomyocytes Depending on the Regulation of the miR-335-3p/TLR4/NF-κB Pathway.
  5. LncRNA SNHG15 Promotes Oxidative Stress Damage to Regulate the Occurrence and Development of Cerebral Ischemia/Reperfusion Injury by Targeting the miR-141/SIRT1 Axis.
    Title: LncRNA SNHG15 Promotes Oxidative Stress Damage to Regulate the Occurrence and Development of Cerebral Ischemia/Reperfusion Injury by Targeting the miR-141/SIRT1 Axis.
  6. Increased serum exosomal long non-coding RNA SNHG15 expression predicts poor prognosis in non-small cell lung cancer.
    Title: Increased serum exosomal long non-coding RNA SNHG15 expression predicts poor prognosis in non-small cell lung cancer.
  7. LncRNA SNHG15 modulates gastric cancer tumorigenesis by impairing miR-506-5p expression.
    Title: LncRNA SNHG15 modulates gastric cancer tumorigenesis by impairing miR-506-5p expression.
  8. Long noncoding RNA small nucleolar RNA host gene 15 deteriorates liver cancer via microRNA-18b-5p/LIM-only 4 axis.
    Title: Long noncoding RNA small nucleolar RNA host gene 15 deteriorates liver cancer via microRNA-18b-5p/LIM-only 4 axis.
  9. lncRNA SNHG15 Promotes Ovarian Cancer Progression through Regulated CDK6 via Sponging miR-370-3p.
    Title: lncRNA SNHG15 Promotes Ovarian Cancer Progression through Regulated CDK6 via Sponging miR-370-3p.
  10. Down-regulation LncRNA-SNHG15 contributes to proliferation and invasion of bladder cancer cells.
    Title: Down-regulation LncRNA-SNHG15 contributes to proliferation and invasion of bladder cancer cells.
Submit: New GeneRIF Correction See all GeneRIFs (35)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

General gene information

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Markers

Other Names

  • MYO1G upstream transcript
  • small nucleolar RNA host gene 15 (non-protein coding)

Clone Names

  • FLJ38860

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_003697.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AA767840, AC004847, BC092459, DB280360
    Related
    ENST00000578968.6

  2. NR_152594.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AA767840, CD639046, DB450983
    Related
    ENST00000580458.6

  3. NR_152595.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC004847
    Related
    ENST00000579383.8

  4. NR_152596.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC004847
    Related
    ENST00000585030.6

  5. NR_152597.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AA488149, AA767840, AC004847, DB450983
    Related
    ENST00000438705.4

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    44983023..44986696 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    45143371..45147061 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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