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LINC00491 long intergenic non-protein coding RNA 491 [ Homo sapiens (human) ]

Gene ID: 285708, updated on 5-Feb-2024

Summary

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Official Symbol
LINC00491provided by HGNC
Official Full Name
long intergenic non-protein coding RNA 491provided by HGNC
Primary source
HGNC:HGNC:43428
See related
Ensembl:ENSG00000250682 AllianceGenome:HGNC:43428
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Low expression observed in reference dataset See more
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Genomic context

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See LINC00491 in Genome Data Viewer
Location:
5q21.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (102608492..102671464, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (103116594..103179563, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (101944196..102007168, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901035 Neighboring gene uncharacterized LOC124901036 Neighboring gene long intergenic non-protein coding RNA 492 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:101996845-101997345 Neighboring gene VISTA enhancer hs1649 Neighboring gene uncharacterized LOC105379104 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16207 Neighboring gene NANOG hESC enhancer GRCh37_chr5:102085276-102085842 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:102090038-102090563 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16208 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:102091571-102092071 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22856 Neighboring gene peptidylglycine alpha-amidating monooxygenase Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16209 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:102363594-102364793 Neighboring gene eukaryotic translation initiation factor 3 subunit K pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. LINC00491 promotes cell growth and metastasis through miR-324-5p/ROCK1 in liver cancer. Wang W, et al. J Transl Med, 2021 Dec 7. PMID 34876144, Free PMC Article
  2. Long non‑coding RNA LINC00491 promotes proliferation and inhibits apoptosis in esophageal squamous cell carcinoma. Ye H, et al. Int J Mol Med, 2021 Apr. PMID 33537830, Free PMC Article
  3. Long non-coding RNAs expressed in pancreatic ductal adenocarcinoma and lncRNA BC008363 an independent prognostic factor in PDAC. Li J, et al. Pancreatology, 2014 Sep-Oct. PMID 25200694
  4. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. Brandenberger R, et al. Nat Biotechnol, 2004 Jun. PMID 15146197
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Long non-coding RNA LINC00491 accelerates head and neck squamous cell carcinoma progression through regulating miR-508-3p/SATB1 axis and activating Wnt signaling pathway.
    Title: Long non-coding RNA LINC00491 accelerates head and neck squamous cell carcinoma progression through regulating miR-508-3p/SATB1 axis and activating Wnt signaling pathway.
  2. Silencing LINC00491 inhibits prostate cancer development through the miR-384/TRIM44 axis.
    Title: Silencing LINC00491 inhibits prostate cancer development through the miR-384/TRIM44 axis.
  3. LINC00491 promotes cell growth and metastasis through miR-324-5p/ROCK1 in liver cancer.
    Title: LINC00491 promotes cell growth and metastasis through miR-324-5p/ROCK1 in liver cancer.
  4. Long noncoding RNA LINC00491 promotes proliferation and inhibits apoptosis in esophageal squamous cell carcinoma.
    Title: Long non‑coding RNA LINC00491 promotes proliferation and inhibits apoptosis in esophageal squamous cell carcinoma.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Other Names

  • CTD-2340E1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_103753.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    AC099487, DA458115, DA458823

  2. NR_103754.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal exon and contains two alternate internal exons, resulting in a shorter transcript, compared to variant 1.
    Source sequence(s)
    AC099487, CN270888, DA458823

  3. NR_103755.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an internal exon and contains an alternate internal exon, resulting in a shorter transcript, compared to variant 1.
    Source sequence(s)
    AC099487, DA458823

  4. NR_103756.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an internal exon, resulting in a shorter transcript, compared to variant 1.
    Source sequence(s)
    AC099487, BG777293, DA458823
    Related
    ENST00000662437.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    102608492..102671464 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    103116594..103179563 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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