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ARL10 ARF like GTPase 10 [ Homo sapiens (human) ]

Gene ID: 285598, updated on 2-Nov-2024

Summary

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Official Symbol
ARL10provided by HGNC
Official Full Name
ARF like GTPase 10provided by HGNC
Primary source
HGNC:HGNC:22042
See related
Ensembl:ENSG00000175414 AllianceGenome:HGNC:22042
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARL10A
Summary
Predicted to enable GTP binding activity and GTPase activity. Located in mitochondrion. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in brain (RPKM 2.9), ovary (RPKM 2.2) and 22 other tissues See more
Orthologs
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Genomic context

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See ARL10 in Genome Data Viewer
Location:
5q35.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (176365487..176415063)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (176909834..176959829)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (175792490..175808912)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene SUMO interacting motifs containing 1 Neighboring gene BRCA1/BRCA2-containing complex subunit 3 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23680 Neighboring gene KIAA1191 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23681 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16649 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:175805661-175805825 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:175815238-175816437 Neighboring gene microRNA 1271 Neighboring gene NOP16 nucleolar protein Neighboring gene HIG1 hypoxia inducible domain family member 2A Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16650 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16651 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16652 Neighboring gene clathrin light chain B Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:175861163-175861909 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23684 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23685 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16653 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23686 Neighboring gene uncharacterized LOC124901142 Neighboring gene Fas associated factor family member 2 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:175918968-175920167 Neighboring gene MPRA-validated peak5588 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23687 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:175961121-175961790 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16654 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16655 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23688 Neighboring gene uncharacterized LOC124901143 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23689 Neighboring gene ring finger protein 44

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. RASL11A, member of a novel small monomeric GTPase gene family, is down-regulated in prostate tumors. Louro R, et al. Biochem Biophys Res Commun, 2004 Apr 9. PMID 15033445
  2. Interactome Analysis of Human Phospholipase D and Phosphatidic Acid-Associated Protein Network. Kattan RE, et al. Mol Cell Proteomics, 2022 Feb. PMID 35007762, Free PMC Article
  3. Comprehensive Proteomic Analysis of PGC7-Interacting Proteins. Liu H, et al. J Proteome Res, 2017 Sep 1. PMID 28712289
  4. A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III. Maio N, et al. Cell Metab, 2017 Apr 4. PMID 28380382
  5. Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB. Li FL, et al. EMBO J, 2022 Sep 1. PMID 35844135, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ39249

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrion HTP PubMed 

General protein information

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Preferred Names
ADP-ribosylation factor-like protein 10
Names
ADP ribosylation factor like GTPase 10
ADP-ribosylation factor-like 10A
ADP-ribosylation factor-like membrane-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317948.2 → NP_001304877.1  ADP-ribosylation factor-like protein 10 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC138956, BC059361
    UniProtKB/TrEMBL
    Q6PCE2
    Conserved Domains (1) summary
    cd04162
    Location:79 → 250
    Arl9_Arfrp2_like; Arf-like 9 (Arl9)/Arfrp2-like GTPase

  2. NM_173664.6 → NP_775935.1  ADP-ribosylation factor-like protein 10 isoform 2

    See identical proteins and their annotated locations for NP_775935.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR compared to variant 1. The encoded isoform (2) has a distinct, shorter C-terminus than isoform 1.
    Source sequence(s)
    AC138956, BC059361, DR001833
    Consensus CDS
    CCDS4400.1
    UniProtKB/Swiss-Prot
    Q8N8L6
    Related
    ENSP00000308496.5, ENST00000310389.6
    Conserved Domains (2) summary
    cd04162
    Location:79 → 237
    Arl9_Arfrp2_like; Arf-like 9 (Arl9)/Arfrp2-like GTPase
    pfam00071
    Location:80 → 218
    Ras; Ras family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    176365487..176415063
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534529.4 → XP_011532831.1  ADP-ribosylation factor-like protein 10 isoform X1

    Conserved Domains (1) summary
    cl21455
    Location:79 → 187
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. XM_011534530.4 → XP_011532832.1  ADP-ribosylation factor-like protein 10 isoform X2

    Conserved Domains (1) summary
    cl21455
    Location:79 → 190
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. XM_011534531.4 → XP_011532833.1  ADP-ribosylation factor-like protein 10 isoform X3

    Conserved Domains (1) summary
    cl21455
    Location:79 → 188
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    176909834..176959829
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054352417.1 → XP_054208392.1  ADP-ribosylation factor-like protein 10 isoform X1

  2. XM_054352418.1 → XP_054208393.1  ADP-ribosylation factor-like protein 10 isoform X2

  3. XM_054352419.1 → XP_054208394.1  ADP-ribosylation factor-like protein 10 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N8L6.1 GenPept UniProtKB/Swiss-Prot:Q8N8L6

Gene LinkOut

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