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IQCM IQ motif containing M [ Homo sapiens (human) ]

Gene ID: 285423, updated on 5-Mar-2024

Summary

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Official Symbol
IQCMprovided by HGNC
Official Full Name
IQ motif containing Mprovided by HGNC
Primary source
HGNC:HGNC:53443
See related
Ensembl:ENSG00000234828 AllianceGenome:HGNC:53443
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Restricted expression toward testis (RPKM 3.1) See more
Orthologs
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Genomic context

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Location:
4q31.23
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (149351709..149815843, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (152673312..153137484, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (150272861..150736995, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2430 Neighboring gene NANOG hESC enhancer GRCh37_chr4:150104754-150105266 Neighboring gene long intergenic non-protein coding RNA 2355 Neighboring gene uncharacterized LOC107986320 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:150262096-150263295 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:150329764-150330963 Neighboring gene uncharacterized LOC105377479 Neighboring gene akirin 2 pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:150769633-150770246 Neighboring gene RNA, U6 small nuclear 1230, pseudogene Neighboring gene RNA, 5S ribosomal pseudogene 167

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Novel associations for hypothyroidism include known autoimmune risk loci. Eriksson N, et al. PLoS One, 2012. PMID 22493691, Free PMC Article
  2. Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity. Kim JJ, et al. Genes Dev, 2019 Dec 1. PMID 31753913, Free PMC Article
  3. The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis. Capalbo L, et al. Nat Commun, 2019 Oct 4. PMID 31586073, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Novel associations for hypothyroidism include known autoimmune risk loci.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

General protein information

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Preferred Names
IQ domain-containing protein M
Names
iQ domain-containing protein M

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363507.2 → NP_001350436.1  IQ domain-containing protein M isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC027058, AC093893, AC096756, AC097465, AC108168
    Consensus CDS
    CCDS87270.1
    UniProtKB/Swiss-Prot
    A0A1B0GVH7
    Related
    ENSP00000490518.1, ENST00000636793.2

  2. NM_001363509.2 → NP_001350438.1  IQ domain-containing protein M isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC027058, AC093893, AC096756, AC108168
    Consensus CDS
    CCDS87271.1
    UniProtKB/TrEMBL
    A0A1B0GUF7
    Related
    ENSP00000490088.1, ENST00000636414.1

  3. NM_001378177.1 → NP_001365106.1  IQ domain-containing protein M isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC027058, AC093893, AC096756, AC108168

  4. NM_001378178.1 → NP_001365107.1  IQ domain-containing protein M isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC027058, AC093893, AC096756, AC108168

  5. NM_001378179.1 → NP_001365108.1  IQ domain-containing protein M isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC027058, AC093893, AC096756, AC108168
    Consensus CDS
    CCDS87271.1
    UniProtKB/TrEMBL
    A0A1B0GUF7

  6. NM_001378180.1 → NP_001365109.1  IQ domain-containing protein M isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC027058, AC093893, AC096756, AC097465, AC108168

  7. NM_001378181.1 → NP_001365110.1  IQ domain-containing protein M isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC027058, AC093893, AC096756, AC108168
    Conserved Domains (1) summary
    smart00015
    Location:153 → 175
    IQ; Calmodulin-binding motif

  8. NM_001378182.1 → NP_001365111.1  IQ domain-containing protein M isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC027058, AC093893, AC096756, AC108168
    Conserved Domains (1) summary
    smart00015
    Location:153 → 175
    IQ; Calmodulin-binding motif

  9. NM_001378184.1 → NP_001365113.1  IQ domain-containing protein M isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC027058, AC093893, AC096756, AC108168
    Conserved Domains (1) summary
    smart00015
    Location:140 → 162
    IQ; Calmodulin-binding motif

  10. NM_001378185.1 → NP_001365114.1  IQ domain-containing protein M isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC093893, AC096756
    UniProtKB/TrEMBL
    A0A1B0GVS1
    Related
    ENSP00000490631.1, ENST00000511993.5

  11. NM_001378186.1 → NP_001365115.1  IQ domain-containing protein M isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC093893, AC096756
    UniProtKB/TrEMBL
    A0A1B0GVS1

  12. NM_001378187.1 → NP_001365116.1  IQ domain-containing protein M isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC093893, AC096756
    UniProtKB/TrEMBL
    A0A1B0GVS1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    149351709..149815843 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008904.3 → XP_016864393.1  IQ domain-containing protein M isoform X4

  2. XM_017008902.3 → XP_016864391.1  IQ domain-containing protein M isoform X1

  3. XM_017008903.3 → XP_016864392.1  IQ domain-containing protein M isoform X2

    UniProtKB/Swiss-Prot
    A0A1B0GVH7

  4. XM_017008900.3 → XP_016864389.1  IQ domain-containing protein M isoform X1

  5. XM_017008901.3 → XP_016864390.1  IQ domain-containing protein M isoform X1

  6. XM_047450076.1 → XP_047306032.1  IQ domain-containing protein M isoform X5

  7. XM_011532456.4 → XP_011530758.1  IQ domain-containing protein M isoform X3

    See identical proteins and their annotated locations for XP_011530758.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    152673312..153137484 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054349708.1 → XP_054205683.1  IQ domain-containing protein M isoform X4

  2. XM_054349704.1 → XP_054205679.1  IQ domain-containing protein M isoform X1

  3. XM_054349706.1 → XP_054205681.1  IQ domain-containing protein M isoform X2

    UniProtKB/Swiss-Prot
    A0A1B0GVH7

  4. XM_054349703.1 → XP_054205678.1  IQ domain-containing protein M isoform X1

  5. XM_054349705.1 → XP_054205680.1  IQ domain-containing protein M isoform X1

  6. XM_054349709.1 → XP_054205684.1  IQ domain-containing protein M isoform X5

  7. XM_054349707.1 → XP_054205682.1  IQ domain-containing protein M isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A1B0GVH7.1 GenPept UniProtKB/Swiss-Prot:A0A1B0GVH7

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