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TPRG1 tumor protein p63 regulated 1 [ Homo sapiens (human) ]

Gene ID: 285386, updated on 5-Mar-2024

Summary

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Official Symbol
TPRG1provided by HGNC
Official Full Name
tumor protein p63 regulated 1provided by HGNC
Primary source
HGNC:HGNC:24759
See related
Ensembl:ENSG00000188001 AllianceGenome:HGNC:24759
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM79B
Summary
Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in esophagus (RPKM 2.6), skin (RPKM 1.9) and 7 other tissues See more
Orthologs
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Genomic context

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Location:
3q28
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (188997227..189325304)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (191813855..192142070)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (188889760..189043093)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 11355 Neighboring gene NANOG hESC enhancer GRCh37_chr3:188674939-188675473 Neighboring gene TPRG1 antisense RNA 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:188740290-188740806 Neighboring gene ENOPH1 pseudogene 1 Neighboring gene uncharacterized LOC107986167 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:188845804-188847003 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:188849592-188850791 Neighboring gene NANOG hESC enhancer GRCh37_chr3:188855097-188855598 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:188884267-188885466 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:188956266-188957465 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20977 Neighboring gene TPRG1 antisense RNA 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20978 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20979 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:189041855-189043054 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20980 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20981 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:189166776-189167320 Neighboring gene uncharacterized LOC105374270 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20982 Neighboring gene TAp63 promoter of tumor protein p63 Neighboring gene tumor protein p63 Neighboring gene DeltaNp63 promoter of tumor protein p63 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14997 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:189526229-189526775 Neighboring gene microRNA 944

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Tumor protein P63 Regulated 1 contributes to inflammation and cell proliferation of cystitis glandularis through regulating the NF-кB/cyclooxygenase-2/prostaglandin E2 axis. Hong T, et al. Bosn J Basic Med Sci, 2022 Feb 1. PMID 34998360, Free PMC Article
  2. Non-replication of association for six polymorphisms from meta-analysis of genome-wide association studies of Parkinson's disease: large-scale collaborative study. Evangelou E, et al. Am J Med Genet B Neuropsychiatr Genet, 2010 Jan 5. PMID 19475631, Free PMC Article
  3. Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error. Cheng CY, et al. Am J Hum Genet, 2013 Aug 8. PMID 24144296, Free PMC Article
  4. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tumor protein P63 Regulated 1 contributes to inflammation and cell proliferation of cystitis glandularis through regulating the NF-small ka, CyrillicB/cyclooxygenase-2/prostaglandin E2 axis.
    Title: Tumor protein P63 Regulated 1 contributes to inflammation and cell proliferation of cystitis glandularis through regulating the NF-кB/cyclooxygenase-2/prostaglandin E2 axis.
  2. Meta-analysis of gene-disease association. (HuGE Navigator)
    Title: Non-replication of association for six polymorphisms from meta-analysis of genome-wide association studies of Parkinson's disease: large-scale collaborative study.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ41238, FLJ43694, MGC126599, MGC126601

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tumor protein p63-regulated gene 1 protein
Names
family with sequence similarity 79, member B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198485.4 → NP_940887.1  tumor protein p63-regulated gene 1 protein

    See identical proteins and their annotated locations for NP_940887.1

    Status: VALIDATED

    Source sequence(s)
    AC104669, AC112909, AK125682, BC101550, CR737485
    Consensus CDS
    CCDS3292.1
    UniProtKB/Swiss-Prot
    Q6ZUI0
    Related
    ENSP00000341031.3, ENST00000345063.8
    Conserved Domains (1) summary
    pfam12456
    Location:70 → 170
    hSac2; Inositol phosphatase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    188997227..189325304
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047448032.1 → XP_047303988.1  tumor protein p63-regulated gene 1 protein isoform X1

  2. XM_047448034.1 → XP_047303990.1  tumor protein p63-regulated gene 1 protein isoform X1

  3. XM_047448028.1 → XP_047303984.1  tumor protein p63-regulated gene 1 protein isoform X1

  4. XM_047448030.1 → XP_047303986.1  tumor protein p63-regulated gene 1 protein isoform X1

  5. XM_047448041.1 → XP_047303997.1  tumor protein p63-regulated gene 1 protein isoform X1

  6. XM_047448029.1 → XP_047303985.1  tumor protein p63-regulated gene 1 protein isoform X1

  7. XM_047448038.1 → XP_047303994.1  tumor protein p63-regulated gene 1 protein isoform X1

  8. XM_047448039.1 → XP_047303995.1  tumor protein p63-regulated gene 1 protein isoform X1

  9. XM_047448037.1 → XP_047303993.1  tumor protein p63-regulated gene 1 protein isoform X1

  10. XM_047448031.1 → XP_047303987.1  tumor protein p63-regulated gene 1 protein isoform X1

  11. XM_024453477.2 → XP_024309245.1  tumor protein p63-regulated gene 1 protein isoform X1

    Conserved Domains (1) summary
    pfam12456
    Location:70 → 190
    hSac2; Inositol phosphatase

  12. XM_047448035.1 → XP_047303991.1  tumor protein p63-regulated gene 1 protein isoform X1

  13. XM_047448040.1 → XP_047303996.1  tumor protein p63-regulated gene 1 protein isoform X1

  14. XM_047448033.1 → XP_047303989.1  tumor protein p63-regulated gene 1 protein isoform X1

  15. XM_047448036.1 → XP_047303992.1  tumor protein p63-regulated gene 1 protein isoform X1

  16. XM_011512732.3 → XP_011511034.2  tumor protein p63-regulated gene 1 protein isoform X1

    Conserved Domains (1) summary
    pfam12456
    Location:70 → 190
    hSac2; Inositol phosphatase

  17. XM_005247388.5 → XP_005247445.1  tumor protein p63-regulated gene 1 protein isoform X7

    Conserved Domains (1) summary
    pfam12456
    Location:78 → 109
    hSac2; Inositol phosphatase

  18. XM_011512736.4 → XP_011511038.1  tumor protein p63-regulated gene 1 protein isoform X6

    Conserved Domains (1) summary
    pfam12456
    Location:78 → 109
    hSac2; Inositol phosphatase

  19. XM_005247382.6 → XP_005247439.1  tumor protein p63-regulated gene 1 protein isoform X2

    Conserved Domains (1) summary
    pfam12456
    Location:78 → 178
    hSac2; Inositol phosphatase

  20. XM_011512735.4 → XP_011511037.1  tumor protein p63-regulated gene 1 protein isoform X4

    Conserved Domains (1) summary
    pfam12456
    Location:78 → 108
    hSac2; Inositol phosphatase

  21. XM_011512734.4 → XP_011511036.1  tumor protein p63-regulated gene 1 protein isoform X3

    Conserved Domains (1) summary
    pfam12456
    Location:78 → 178
    hSac2; Inositol phosphatase

  22. XM_017006263.1 → XP_016861752.1  tumor protein p63-regulated gene 1 protein isoform X5

  23. XM_047448042.1 → XP_047303998.1  tumor protein p63-regulated gene 1 protein isoform X5

RNA

  1. XR_001740120.3 RNA Sequence

  2. XR_007095667.1 RNA Sequence

  3. XR_007095668.1 RNA Sequence

  4. XR_007095669.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    191813855..192142070
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054346339.1 → XP_054202314.1  tumor protein p63-regulated gene 1 protein isoform X1

  2. XM_054346337.1 → XP_054202312.1  tumor protein p63-regulated gene 1 protein isoform X1

  3. XM_054346340.1 → XP_054202315.1  tumor protein p63-regulated gene 1 protein isoform X1

  4. XM_054346338.1 → XP_054202313.1  tumor protein p63-regulated gene 1 protein isoform X1

  5. XM_054346342.1 → XP_054202317.1  tumor protein p63-regulated gene 1 protein isoform X1

  6. XM_054346345.1 → XP_054202320.1  tumor protein p63-regulated gene 1 protein isoform X1

  7. XM_054346348.1 → XP_054202323.1  tumor protein p63-regulated gene 1 protein isoform X1

  8. XM_054346346.1 → XP_054202321.1  tumor protein p63-regulated gene 1 protein isoform X1

  9. XM_054346343.1 → XP_054202318.1  tumor protein p63-regulated gene 1 protein isoform X1

  10. XM_054346344.1 → XP_054202319.1  tumor protein p63-regulated gene 1 protein isoform X1

  11. XM_054346349.1 → XP_054202324.1  tumor protein p63-regulated gene 1 protein isoform X1

  12. XM_054346347.1 → XP_054202322.1  tumor protein p63-regulated gene 1 protein isoform X1

  13. XM_054346341.1 → XP_054202316.1  tumor protein p63-regulated gene 1 protein isoform X1

  14. XM_054346351.1 → XP_054202326.1  tumor protein p63-regulated gene 1 protein isoform X3

  15. XM_054346356.1 → XP_054202331.1  tumor protein p63-regulated gene 1 protein isoform X7

  16. XM_054346355.1 → XP_054202330.1  tumor protein p63-regulated gene 1 protein isoform X6

  17. XM_054346350.1 → XP_054202325.1  tumor protein p63-regulated gene 1 protein isoform X2

  18. XM_054346352.1 → XP_054202327.1  tumor protein p63-regulated gene 1 protein isoform X4

  19. XM_054346354.1 → XP_054202329.1  tumor protein p63-regulated gene 1 protein isoform X5

  20. XM_054346353.1 → XP_054202328.1  tumor protein p63-regulated gene 1 protein isoform X5

RNA

  1. XR_007074062.1 RNA Sequence

  2. XR_007074061.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZUI0.1 GenPept UniProtKB/Swiss-Prot:Q6ZUI0

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