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GPR27 G protein-coupled receptor 27 [ Homo sapiens (human) ]

Gene ID: 2850, updated on 5-Mar-2024

Summary

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Official Symbol
GPR27provided by HGNC
Official Full Name
G protein-coupled receptor 27provided by HGNC
Primary source
HGNC:HGNC:4482
See related
Ensembl:ENSG00000170837 MIM:605187; AllianceGenome:HGNC:4482
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SREB1
Summary
GPR27 is a member of the G protein-coupled receptors (GPCRs), a large family of receptors that have a similar structure characterized by 7 transmembrane domains. Activation of GPCRs by extracellular stimuli such as neurotransmitters, hormones, or light induces an intracellular signaling cascade mediated by heterotrimeric GTP-binding proteins, or G proteins.[supplied by OMIM, May 2010]
Orthologs
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Genomic context

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Location:
3p13
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (71753855..71756496)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (71793122..71795766)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (71803006..71805647)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene FOXP1 divergent transcript Neighboring gene uncharacterized LOC105377155 Neighboring gene NANOG hESC enhancer GRCh37_chr3:71694238-71694747 Neighboring gene eukaryotic translation initiation factor 4E family member 3 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:71752927-71753508 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20064 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14521 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14522 Neighboring gene Sharpr-MPRA regulatory region 3624 Neighboring gene uncharacterized LOC105377156 Neighboring gene prokineticin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system. Matsumoto M, et al. Biochem Biophys Res Commun, 2000 Jun 7. PMID 10833454
  2. Whole genome RNAi screens reveal a critical role of REV3 in coping with replication stress. Kotov IN, et al. Mol Oncol, 2014 Dec. PMID 25113059, Free PMC Article
  3. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Prognostic significance and immune characteristics of GPR27 in gastric cancer.
    Title: Prognostic significance and immune characteristics of GPR27 in gastric cancer.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
probable G-protein coupled receptor 27
Names
super conserved receptor expressed in brain 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018971.3 → NP_061844.1  probable G-protein coupled receptor 27

    See identical proteins and their annotated locations for NP_061844.1

    Status: VALIDATED

    Source sequence(s)
    AC096970
    Consensus CDS
    CCDS2915.1
    UniProtKB/Swiss-Prot
    Q9NS67
    UniProtKB/TrEMBL
    F1DAM3
    Related
    ENSP00000303149.2, ENST00000304411.3
    Conserved Domains (1) summary
    cd15216
    Location:19 → 349
    7tmA_SREB1_GPR27; super conserved receptor expressed in brain 1 (or GPR27), member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    71753855..71756496
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    71793122..71795766
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NS67.1 GenPept UniProtKB/Swiss-Prot:Q9NS67

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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