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RNF149 ring finger protein 149 [ Homo sapiens (human) ]

Gene ID: 284996, updated on 2-Nov-2024

Summary

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Official Symbol
RNF149provided by HGNC
Official Full Name
ring finger protein 149provided by HGNC
Primary source
HGNC:HGNC:23137
See related
Ensembl:ENSG00000163162 AllianceGenome:HGNC:23137
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DNAPTP2
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within cellular response to xenobiotic stimulus; negative regulation of MAPK cascade; and regulation of protein stability. Located in membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bone marrow (RPKM 14.1), appendix (RPKM 12.5) and 25 other tissues See more
Orthologs
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Genomic context

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See RNF149 in Genome Data Viewer
Location:
2q11.2
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (101271219..101308701, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (101729922..101767398, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (101892063..101925163, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124906053 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:101869253-101870165 Neighboring gene uncharacterized LOC105373511 Neighboring gene CCR4-NOT transcription complex subunit 11 Neighboring gene small nucleolar RNA, C/D box 89 Neighboring gene uncharacterized LOC124906052 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16300 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16301 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11823 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11824 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11825 Neighboring gene uncharacterized LOC105373512 Neighboring gene microRNA 5696 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr2:101946330-101947106 and GRCh37_chr2:101947107-101947883 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr2:101955361-101956145 Neighboring gene cellular repressor of E1A stimulated genes 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:101986959-101987460 Neighboring gene succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Ring finger protein 149 is an E3 ubiquitin ligase active on wild-type v-Raf murine sarcoma viral oncogene homolog B1 (BRAF). Hong SW, et al. J Biol Chem, 2012 Jul 6. PMID 22628551, Free PMC Article
  2. Genome-wide association study of pancreatic cancer in Japanese population. Low SK, et al. PLoS One, 2010 Jul 29. PMID 20686608, Free PMC Article
  3. The role of RNF149 in the pre-emptive quality control substrate ubiquitination. Legesse A, et al. Commun Biol, 2023 Apr 8. PMID 37031316, Free PMC Article
  4. A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition. Benslimane Y, et al. Aging Cell, 2021 Apr. PMID 33660365, Free PMC Article
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Hillier LW, et al. Nature, 2005 Apr 7. PMID 15815621

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that RNF149 (RING finger protein 149) interacts with wild-type BRAF.
    Title: Ring finger protein 149 is an E3 ubiquitin ligase active on wild-type v-Raf murine sarcoma viral oncogene homolog B1 (BRAF).
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of pancreatic cancer in Japanese population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ90504

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein stability IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in late endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane HDA PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase RNF149
Names
DNA polymerase-transactivated protein 2
RING-type E3 ubiquitin transferase RNF149
NP_775918.2
XP_005263977.1
XP_005263978.1
XP_024308579.1
XP_047299935.1
XP_054197453.1
XP_054197454.1
XP_054197455.1
XP_054197456.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173647.4 → NP_775918.2  E3 ubiquitin-protein ligase RNF149 precursor

    See identical proteins and their annotated locations for NP_775918.2

    Status: VALIDATED

    Source sequence(s)
    AC013722, AC073643, DA383672
    Consensus CDS
    CCDS2051.1
    UniProtKB/Swiss-Prot
    Q53S14, Q8N5I8, Q8NBY5, Q8NC42, Q8WUU3
    UniProtKB/TrEMBL
    F8WCD0
    Related
    ENSP00000295317.3, ENST00000295317.4
    Conserved Domains (3) summary
    cd02122
    Location:43 → 185
    PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
    pfam13639
    Location:267 → 310
    zf-RING_2; Ring finger domain
    cl11506
    Location:204 → 235
    UPF0233; uncharacterized protein family (UPF0233)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    101271219..101308701 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005263921.5 → XP_005263978.1  E3 ubiquitin-protein ligase RNF149 isoform X2

    UniProtKB/TrEMBL
    F8WCD0
    Conserved Domains (3) summary
    cd02122
    Location:43 → 185
    PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
    pfam13639
    Location:267 → 310
    zf-RING_2; Ring finger domain
    cl11506
    Location:204 → 235
    UPF0233; uncharacterized protein family (UPF0233)

  2. XM_024452811.2 → XP_024308579.1  E3 ubiquitin-protein ligase RNF149 isoform X3

    UniProtKB/TrEMBL
    F8WCD0
    Conserved Domains (2) summary
    cd02122
    Location:43 → 185
    PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
    cd16804
    Location:268 → 315
    RING-H2_RNF149; RING finger, H2 subclass, found in RING finger protein 149 (RNF149) and similar proteins

  3. XM_005263920.4 → XP_005263977.1  E3 ubiquitin-protein ligase RNF149 isoform X1

    UniProtKB/TrEMBL
    F8WCD0
    Conserved Domains (3) summary
    cd02122
    Location:43 → 185
    PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
    pfam13639
    Location:267 → 310
    zf-RING_2; Ring finger domain
    cl11506
    Location:204 → 235
    UPF0233; uncharacterized protein family (UPF0233)

  4. XM_047443979.1 → XP_047299935.1  E3 ubiquitin-protein ligase RNF149 isoform X4

RNA

  1. XR_001738712.3 RNA Sequence

  2. XR_922908.3 RNA Sequence

    Related
    ENST00000424632.5

  3. XR_922909.4 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    101729922..101767398 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054341479.1 → XP_054197454.1  E3 ubiquitin-protein ligase RNF149 isoform X2

  2. XM_054341480.1 → XP_054197455.1  E3 ubiquitin-protein ligase RNF149 isoform X3

  3. XM_054341478.1 → XP_054197453.1  E3 ubiquitin-protein ligase RNF149 isoform X1

  4. XM_054341481.1 → XP_054197456.1  E3 ubiquitin-protein ligase RNF149 isoform X4

RNA

  1. XR_008486330.1 RNA Sequence

  2. XR_008486331.1 RNA Sequence

  3. XR_008486332.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NC42.2 GenPept UniProtKB/Swiss-Prot:Q8NC42

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