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AATBC apoptosis associated transcript in bladder cancer [ Homo sapiens (human) ]

Gene ID: 284837, updated on 17-Sep-2024

Summary

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Official Symbol
AATBCprovided by HGNC
Official Full Name
apoptosis associated transcript in bladder cancerprovided by HGNC
Primary source
HGNC:HGNC:51526
See related
Ensembl:ENSG00000215458 AllianceGenome:HGNC:51526
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in skin (RPKM 2.8), urinary bladder (RPKM 1.3) and 13 other tissues See more
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Genomic context

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See AATBC in Genome Data Viewer
Location:
21q22.3
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (43805758..43812567, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (42161368..42168177, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (45225639..45232448, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45206281-45206822 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45206823-45207363 Neighboring gene transmembrane protein 97 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13369 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18548 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13370 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:45211808-45212020 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45213337-45213836 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45213839-45214490 Neighboring gene ribosomal RNA processing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18549 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18550 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18551 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45230034-45230950 Neighboring gene uncharacterized LOC124905033 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:45269891-45270437 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18552 Neighboring gene MYL6 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. LncRNA AATBC indicates development and facilitates cell growth and metastasis of cervical cancer as a sponge of miR-1245b-5p. Liu YQ, et al. Kaohsiung J Med Sci, 2023 Feb. PMID 36420764
  2. LncRNA AATBC regulates Pinin to promote metastasis in nasopharyngeal carcinoma. Tang T, et al. Mol Oncol, 2020 Sep. PMID 32364663, Free PMC Article
  3. Knockdown of a novel lincRNA AATBC suppresses proliferation and induces apoptosis in bladder cancer. Zhao F, et al. Oncotarget, 2015 Jan 20. PMID 25473900, Free PMC Article
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LncRNA AATBC indicates development and facilitates cell growth and metastasis of cervical cancer as a sponge of miR-1245b-5p.
    Title: LncRNA AATBC indicates development and facilitates cell growth and metastasis of cervical cancer as a sponge of miR-1245b-5p.
  2. LncRNA AATBC regulates Pinin to promote metastasis in nasopharyngeal carcinoma.
    Title: LncRNA AATBC regulates Pinin to promote metastasis in nasopharyngeal carcinoma.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Clone Names

  • MGC133248, AP001053.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_026961.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK128598, AP001053, BC031911, BC034348
    Related
    ENST00000400385.2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    43805758..43812567 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    42161368..42168177 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_194310.1: Suppressed sequence

    Description
    NM_194310.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZR03.1 GenPept UniProtKB/Swiss-Prot:Q6ZR03

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.