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MIR646HG MIR646 host gene [ Homo sapiens (human) ]

Gene ID: 284757, updated on 10-Oct-2023

Summary

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Official Symbol
MIR646HGprovided by HGNC
Official Full Name
MIR646 host geneprovided by HGNC
Primary source
HGNC:HGNC:27659
See related
Ensembl:ENSG00000228340 AllianceGenome:HGNC:27659
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Low expression observed in reference dataset See more
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Genomic context

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Location:
20q13.33
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (60138492..60322256)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (61922778..62107446)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (58713548..58897314)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18192 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18193 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:58633003-58633804 Neighboring gene long intergenic non-protein coding RNA 2910 Neighboring gene uncharacterized LOC729296 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:58677553-58677708 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:58686253-58686792 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:58786198-58786437 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:58788309-58788809 Neighboring gene uncharacterized LOC105372698 Neighboring gene NANOG hESC enhancer GRCh37_chr20:58847405-58847906 Neighboring gene uncharacterized LOC105372697 Neighboring gene microRNA 646 Neighboring gene MT-CO2 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. MiR-646 regulates proliferation and migration of laryngeal carcinoma through the PI3K/AKT pathway via targeting GPX1. Yuan X, et al. Oral Dis, 2021 Oct. PMID 33150676
  2. New susceptibility loci associated with kidney disease in type 1 diabetes. Sandholm N, et al. PLoS Genet, 2012 Sep. PMID 23028342, Free PMC Article
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MiR-646 regulates proliferation and migration of laryngeal carcinoma through the PI3K/AKT pathway via targeting GPX1.
    Title: MiR-646 regulates proliferation and migration of laryngeal carcinoma through the PI3K/AKT pathway via targeting GPX1.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
New susceptibility loci associated with kidney disease in type 1 diabetes.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Other Names

  • MIR646 host gene (non-protein coding)

Clone Names

  • FLJ46426

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_046099.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK092805, AL035070
    Related
    ENST00000432910.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    60138492..60322256
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    61922778..62107446
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001004305.1: Suppressed sequence

    Description
    NM_001004305.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate, and because currently there is support for the transcript but not for the protein.
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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