EPHA10 EPH receptor A10 [Homo sapiens (human)] - Gene

Summary

Official Symbol: EPHA10provided by HGNC
Official Full Name: EPH receptor A10provided by HGNC
Primary source: HGNC:HGNC:19987
See related: Ensembl:ENSG00000183317 MIM:611123; AllianceGenome:HGNC:19987
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DFNA88
Summary: Ephrin receptors, the largest subfamily of receptor tyrosine kinases (RTKs), and their ephrin ligands are important mediators of cell-cell communication regulating cell attachment, shape, and mobility in neuronal and epithelial cells (Aasheim et al., 2005 [PubMed 15777695]). See MIM 179610 for additional background on Eph receptors and ephrins.[supplied by OMIM, Mar 2008]
Expression: Biased expression in testis (RPKM 7.0), colon (RPKM 2.9) and 7 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p34.3

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (37713880..37765120, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (37578599..37629649, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (38181648..38230792, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A non-coding variant in 5' untranslated region drove up-regulation of pseudo-kinase EPHA10 and caused non-syndromic hearing loss in humans.
Title: A non-coding variant in 5' untranslated region drove up-regulation of pseudo-kinase EPHA10 and caused non-syndromic hearing loss in humans.
EphA10 drives tumor progression and immune evasion by regulating the MAPK/ERK cascade in lung adenocarcinoma.
Title: EphA10 drives tumor progression and immune evasion by regulating the MAPK/ERK cascade in lung adenocarcinoma.
Coexpression of EphA10 and Gli3 promotes breast cancer cell proliferation, invasion and migration.
Title: Coexpression of EphA10 and Gli3 promotes breast cancer cell proliferation, invasion and migration.
Ephrin A4-ephrin receptor A10 signaling promotes cell migration and spheroid formation by upregulating NANOG expression in oral squamous cell carcinoma cells.
Title: Ephrin A4-ephrin receptor A10 signaling promotes cell migration and spheroid formation by upregulating NANOG expression in oral squamous cell carcinoma cells.
Cataloguing the dead: breathing new life into pseudokinase research.
Title: Cataloguing the dead: breathing new life into pseudokinase research.
we defined the novel interaction via expression patterns of EphA10s and EphA10 that promote malignant transformation of breast cancer, and demonstrated the potential benefit in clinical usage.
Title: Isoform expression patterns of EPHA10 protein mediate breast cancer progression by regulating the E-Cadherin and β-catenin complex.
We have demonstrated the physical association and cellular co-localization of EPHA7 and EPHA10 in breast carcinoma cells. The nuclear co-localization of these two receptors in invasive MDA-MB-231 cells suggests their involvement in transcriptional activation of genes involved in invasiveness.
Title: EPHA7 and EPHA10 Physically Interact and Differentially Co-localize in Normal Breast and Breast Carcinoma Cell Lines, and the Co-localization Pattern Is Altered in EPHB6-expressing MDA-MB-231 Cells.
Ephrin receptor A10 is a promising drug target potentially useful for breast cancers including triple negative breast cancers
Title: Ephrin receptor A10 is a promising drug target potentially useful for breast cancers including triple negative breast cancers.
Therefore, the idea was conceived that the overexpression of EphA10 in prostate cancers might have a potential as a target for prostate cancer therapy, and formed the basis for the studies reported here.
Title: Eph receptor A10 has a potential as a target for a prostate cancer therapy.
EphA10 expression at both the gene and protein level in clinical breast cancer tissues is significantly associated with lymph node metastasis as well as stage progression.
Title: Expression of Eph receptor A10 is correlated with lymph node metastasis and stage progression in breast cancer patients.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Hearing loss, autosomal dominant 88 MedGen: C5830355 OMIM: 620283 GeneReviews: Not available	not available

EBI GWAS Catalog

Description
A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. EBI GWAS Catalog EBI GWAS CatalogPubMed
Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10S275 (e-PCR)
- UniSTS:147992

D8S2279 (e-PCR)
- UniSTS:473907

RH99295 (e-PCR)
- UniSTS:84577

D10S16 (e-PCR)
- UniSTS:155756

RH36905 (e-PCR)
- UniSTS:87932

D1S186 (e-PCR), detects polymorphism
- UniSTS:146599

SHGC-145791 (e-PCR)
- UniSTS:174795

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GPI-linked ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables boss receptor activity	IEA Inferred from Electronic Annotation more info
enables brain-derived neurotrophic factor receptor activity	IEA Inferred from Electronic Annotation more info
enables epidermal growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables fibroblast growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables hepatocyte growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables insulin receptor activity	IEA Inferred from Electronic Annotation more info
enables insulin-like growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables macrophage colony-stimulating factor receptor activity	IEA Inferred from Electronic Annotation more info
enables placental growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor alpha-receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor beta-receptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase collagen receptor activity	IEA Inferred from Electronic Annotation more info
enables stem cell factor receptor activity	IEA Inferred from Electronic Annotation more info
enables transmembrane-ephrin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane-ephrin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables vascular endothelial growth factor receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Kit signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in brain-derived neurotrophic factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in collagen-activated tyrosine kinase receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in ephrin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ephrin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in hepatocyte growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in macrophage colony-stimulating factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in platelet-derived growth factor receptor-alpha signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in platelet-derived growth factor receptor-beta signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in vascular endothelial growth factor receptor-1 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in vascular endothelial growth factor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: ephrin type-A receptor 10

Names: EphA10s protein

NP_001092909.1

EC 2.7.10.1

NP_775912.2

EC 2.7.10.1

XP_016856569.1

EC 2.7.10.1

XP_016856570.1

EC 2.7.10.1

XP_047274347.1

EC 2.7.10.1

XP_047274359.1

EC 2.7.10.1

XP_054192110.1

EC 2.7.10.1

XP_054192111.1

EC 2.7.10.1

XP_054192112.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001099439.2 → NP_001092909.1 ephrin type-A receptor 10 isoform 3 precursor

See identical proteins and their annotated locations for NP_001092909.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) represents the longer transcript and encodes the longer isoform (3).

Source sequence(s)

AC104336, AJ872185, BC039363, BC041360

Consensus CDS

CCDS41305.1

UniProtKB/Swiss-Prot

A4FU89, J3KPB5, Q5JZY3, Q6NW42

UniProtKB/TrEMBL

J3KQG3

Related

ENSP00000362139.4, ENST00000373048.9

Conserved Domains (8) summary

cd05064
Location:639 → 904

PTKc_EphR_A10; Catalytic domain of the Protein Tyrosine Kinase, Ephrin Receptor A10

smart00454
Location:932 → 997

SAM; Sterile alpha motif

cd00063
Location:451 → 531

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:339 → 431

fn3; Fibronectin type III domain

pfam07714
Location:645 → 900

Pkinase_Tyr; Protein tyrosine kinase

pfam14575
Location:573 → 640

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

cl02704
Location:35 → 210

EphR_LBD; Ligand Binding Domain of Ephrin Receptors

cl15755
Location:929 → 998

SAM_superfamily; SAM (Sterile alpha motif )
NM_173641.3 → NP_775912.2 ephrin type-A receptor 10 isoform 2 precursor

See identical proteins and their annotated locations for NP_775912.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains only the first three exons and some of the third intron compared to variant 3. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 3.

Source sequence(s)

AJ781169, AK090974, BC067734

Consensus CDS

CCDS425.1

UniProtKB/TrEMBL

Q8N289

Related

ENSP00000316395.6, ENST00000319637.6

Conserved Domains (1) summary

cl02704
Location:35 → 210

EphR_LBD; Ligand Binding Domain of Ephrin Receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

37713880..37765120 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017001080.1 → XP_016856569.1 ephrin type-A receptor 10 isoform X1

UniProtKB/TrEMBL

Q6ZNH1

Related

ENST00000446149.6
XM_047418403.1 → XP_047274359.1 ephrin type-A receptor 10 isoform X4

Related

ENSP00000431389.1, ENST00000534097.5
XM_017001081.2 → XP_016856570.1 ephrin type-A receptor 10 isoform X3
XM_047418391.1 → XP_047274347.1 ephrin type-A receptor 10 isoform X2

RNA

XR_946610.2 RNA Sequence
XR_001737124.2 RNA Sequence
XR_946613.3 RNA Sequence
XR_001737123.2 RNA Sequence
XR_001737125.3 RNA Sequence
XR_001737127.1 RNA Sequence
XR_001737126.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

NC_060925.1 Alternate T2T-CHM13v2.0

Range

37578599..37629649 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054336135.1 → XP_054192110.1 ephrin type-A receptor 10 isoform X1
XM_054336137.1 → XP_054192112.1 ephrin type-A receptor 10 isoform X4
XM_054336136.1 → XP_054192111.1 ephrin type-A receptor 10 isoform X3

RNA

XR_008486004.1 RNA Sequence
XR_008486003.1 RNA Sequence
XR_008486001.1 RNA Sequence
XR_008486002.1 RNA Sequence
XR_008486005.1 RNA Sequence
XR_008486007.1 RNA Sequence
XR_008486006.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001004338.2: Suppressed sequence

Description

NM_001004338.2: This RefSeq was permanently suppressed because the encoded protein is partial, and it is a nonsense-mediated mRNA decay (NMD) candidate.