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EEIG2 EEIG family member 2 [ Homo sapiens (human) ]

Gene ID: 284611, updated on 5-Mar-2024

Summary

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Official Symbol
EEIG2provided by HGNC
Official Full Name
EEIG family member 2provided by HGNC
Primary source
HGNC:HGNC:27637
See related
Ensembl:ENSG00000162636 AllianceGenome:HGNC:27637
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SYM-3B; FAM102B
Expression
Ubiquitous expression in brain (RPKM 11.6), gall bladder (RPKM 11.3) and 24 other tissues See more
Orthologs
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Genomic context

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Location:
1p13.3
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (108560100..108639322)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (108593088..108672314)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (109102722..109181944)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:109045678-109046211 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1134 Neighboring gene ST13, Hsp70 interacting protein pseudogene 21 Neighboring gene RPL7L1 pseudogene 21 Neighboring gene NANOG hESC enhancer GRCh37_chr1:109060171-109060846 Neighboring gene CRISPRi-validated cis-regulatory element chr1.7484 Neighboring gene Sharpr-MPRA regulatory region 3357 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1135 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1423 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1424 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:109111447-109111662 Neighboring gene MPRA-validated peak351 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:109203434-109204023 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:109204024-109204612 Neighboring gene HEN methyltransferase 1 Neighboring gene uncharacterized LOC105378890

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. UBE2O and USP7 co-regulate RECQL4 ubiquitinylation and homologous recombination-mediated DNA repair. Huang Q, et al. FASEB J, 2022 Jan. PMID 34921745
  2. Histone-binding of DPF2 mediates its repressive role in myeloid differentiation. Huber FM, et al. Proc Natl Acad Sci U S A, 2017 Jun 6. PMID 28533407, Free PMC Article
  3. RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity. Guderian G, et al. J Biol Chem, 2011 Jan 21. PMID 21081503, Free PMC Article
  4. SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk. Lukinović V, et al. Cancer Discov, 2022 Sep 2. PMID 35819319, Free PMC Article
  5. The DNA sequence and biological annotation of human chromosome 1. Gregory SG, et al. Nature, 2006 May 18. PMID 16710414

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp779B126, DKFZp686N01110

General protein information

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Preferred Names
EEIG family member 2
Names
family with sequence similarity 102 member B
protein FAM102B
sym-3 homolog B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001010883.3 → NP_001010883.2  EEIG family member 2

    See identical proteins and their annotated locations for NP_001010883.2

    Status: VALIDATED

    Source sequence(s)
    AL160171
    Consensus CDS
    CCDS30786.2
    UniProtKB/Swiss-Prot
    A1L1A1, B0QZ46, B0QZ47, Q5T8I3, Q68DH7
    Related
    ENSP00000359052.3, ENST00000370035.8
    Conserved Domains (1) summary
    pfam10358
    Location:9 → 149
    NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    108560100..108639322
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    108593088..108672314
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5T8I3.2 GenPept UniProtKB/Swiss-Prot:Q5T8I3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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