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SCGB2B2 secretoglobin family 2B member 2 [ Homo sapiens (human) ]

Gene ID: 284402, updated on 5-Mar-2024

Summary

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Official Symbol
SCGB2B2provided by HGNC
Official Full Name
secretoglobin family 2B member 2provided by HGNC
Primary source
HGNC:HGNC:27616
See related
Ensembl:ENSG00000205209 MIM:615063; AllianceGenome:HGNC:27616
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SCGBL; SCGB4A2
Summary
Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
all
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Genomic context

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Location:
19q13.11
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (34585529..34677159, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (37130104..37221748, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (35076434..35168064, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein S26 pseudogene 55 Neighboring gene zinc finger protein 807, pseudogene Neighboring gene uncharacterized LOC105372374 Neighboring gene secretoglobin family 1B member 2, pseudogene Neighboring gene zinc finger protein 530-like Neighboring gene secretoglobin family 2B member 3, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35154774-35155274 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:35167555-35168452 Neighboring gene secretoglobin family 1B member 3, pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:35168453-35169349 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:35170207-35170708 Neighboring gene zinc finger protein 302 Neighboring gene secretoglobin family 2B member 1, pseudogene Neighboring gene secretoglobin family 1B member 1, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Update of the human secretoglobin (SCGB) gene superfamily and an example of 'evolutionary bloom' of androgen-binding protein genes within the mouse Scgb gene superfamily. Jackson BC, et al. Hum Genomics, 2011 Oct. PMID 22155607, Free PMC Article
  2. Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins. Yang J, et al. Cell Rep, 2023 Feb 28. PMID 36724073
  3. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. Fei T, et al. Proc Natl Acad Sci U S A, 2017 Jun 27. PMID 28611215, Free PMC Article
  4. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
secretoglobin family 2B member 2
Names
secretoglobin-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025591.4 → NP_001020762.1  secretoglobin family 2B member 2 precursor

    See identical proteins and their annotated locations for NP_001020762.1

    Status: VALIDATED

    Source sequence(s)
    AC020910, AC022143, AK093495
    Consensus CDS
    CCDS32989.1
    UniProtKB/Swiss-Prot
    Q4G0G5
    Related
    ENSP00000469876.1, ENST00000601241.6
    Conserved Domains (1) summary
    pfam01099
    Location:30 → 91
    Uteroglobin; Uteroglobin family

RNA

  1. NR_170946.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC020910, AC022143

  2. NR_170947.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC020910, AC022143

  3. NR_170948.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC020910, AC022143

  4. NR_170949.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC020910, AC022143

  5. NR_170950.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC020910, AC022143

  6. NR_170951.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC020910, AC022143

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    34585529..34677159 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    37130104..37221748 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4G0G5.1 GenPept UniProtKB/Swiss-Prot:Q4G0G5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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