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SIGLEC17P sialic acid binding Ig like lectin 17, pseudogene [ Homo sapiens (human) ]

Gene ID: 284367, updated on 22-Oct-2024

Summary

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Official Symbol
SIGLEC17Pprovided by HGNC
Official Full Name
sialic acid binding Ig like lectin 17, pseudogeneprovided by HGNC
Primary source
HGNC:HGNC:15604
See related
Ensembl:ENSG00000291114 AllianceGenome:HGNC:15604
Gene type
pseudo
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSPC078; SIGLECP2; SIGLECP3
Expression
Broad expression in lung (RPKM 3.9), spleen (RPKM 2.3) and 15 other tissues See more
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Genomic context

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See SIGLEC17P in Genome Data Viewer
Location:
19q13.41
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (51167328..51173524)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (54255942..54262138)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51670585..51676780)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904749 Neighboring gene sialic acid binding Ig like lectin 7 Neighboring gene uncharacterized LOC101928517 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:51660802-51661000 Neighboring gene Sharpr-MPRA regulatory region 7523 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:51684473-51685444 Neighboring gene uncharacterized LOC107985327 Neighboring gene sialic acid binding Ig like lectin 20, pseudogene Neighboring gene zinc finger DHHC-type palmitoyltransferase 7 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15010

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The diagnostic and prognostic value of pseudogene SIGLEC17P in lung adenocarcinoma and a preliminary functional study. Shen X, et al. Cell Biol Int, 2023 Jan. PMID 36183365
  2. Specific inactivation of two immunomodulatory SIGLEC genes during human evolution. Wang X, et al. Proc Natl Acad Sci U S A, 2012 Jun 19. PMID 22665810, Free PMC Article
  3. Genomic organization of the siglec gene locus on chromosome 19q13.4 and cloning of two new siglec pseudogenes. Yousef GM, et al. Gene, 2002 Mar 20. PMID 11943481
  4. A second uniquely human mutation affecting sialic acid biology. Angata T, et al. J Biol Chem, 2001 Oct 26. PMID 11546777
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The diagnostic and prognostic value of pseudogene SIGLEC17P in lung adenocarcinoma and a preliminary functional study.
    Title: The diagnostic and prognostic value of pseudogene SIGLEC17P in lung adenocarcinoma and a preliminary functional study.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Other Names

  • sialic acid binding Ig-like lectin, pseudogene 3
  • silec pseudogene-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_047529.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    AC063977, AK301336, BC041072
    Related
    ENST00000614626.3

  2. NR_047530.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal exon and uses an alternate splice site in the 3' region, compared to variant 1.
    Source sequence(s)
    AC063977, BC041072
    Related
    ENST00000618545.5

  3. NR_047531.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an internal exon compared to variant 1.
    Source sequence(s)
    AC063977, AF150143, BC041072
    Related
    ENST00000611992.6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    51167328..51173524
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    54255942..54262138
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_002804.2: Suppressed sequence

    Description
    NR_002804.2: This RefSeq was permanently suppressed because it contains intronic sequence.
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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