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ZSCAN1 zinc finger and SCAN domain containing 1 [ Homo sapiens (human) ]

Gene ID: 284312, updated on 5-Mar-2024

Summary

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Official Symbol
ZSCAN1provided by HGNC
Official Full Name
zinc finger and SCAN domain containing 1provided by HGNC
Primary source
HGNC:HGNC:23712
See related
Ensembl:ENSG00000152467 MIM:620026; AllianceGenome:HGNC:23712
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MZF-1; ZNF915
Summary
Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of chromatin. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
all
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Genomic context

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See ZSCAN1 in Genome Data Viewer
Location:
19q13.43
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (58034025..58056502)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (61130974..61155728)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58545393..58565999)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 606 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15175 Neighboring gene ZNF606 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15176 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15177 Neighboring gene vomeronasal 2 receptor 19, pseudogene Neighboring gene Sharpr-MPRA regulatory region 748 Neighboring gene leucine zipper and EF-hand containing transmembrane protein 1 pseudogene 2 Neighboring gene HNRNPDL pseudogene 4 Neighboring gene zinc finger protein 135 Neighboring gene RNA, 7SL, cytoplasmic 526, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ZSCAN1 Autoantibodies Are Associated with Pediatric Paraneoplastic ROHHAD. Mandel-Brehm C, et al. Ann Neurol, 2022 Aug. PMID 35466441, Free PMC Article
  2. A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells. Anders L, et al. Cancer Cell, 2011 Nov 15. PMID 22094256, Free PMC Article
  3. Development and application of a DNA microarray-based yeast two-hybrid system. Suter B, et al. Nucleic Acids Res, 2013 Feb 1. PMID 23275563, Free PMC Article
  4. Phospho-tyrosine dependent protein-protein interaction network. Grossmann A, et al. Mol Syst Biol, 2015 Mar 26. PMID 25814554, Free PMC Article
  5. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Yin Y, et al. Science, 2017 May 5. PMID 28473536, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ33779, MGC104472

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of chromatin ISA
Inferred from Sequence Alignment
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger and SCAN domain-containing protein 1
Names
zinc finger with SCAN domain 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_182572.4 → NP_872378.3  zinc finger and SCAN domain-containing protein 1

    See identical proteins and their annotated locations for NP_872378.3

    Status: VALIDATED

    Source sequence(s)
    AC008751, AC008969
    Consensus CDS
    CCDS12969.1
    UniProtKB/Swiss-Prot
    Q3B798, Q6WLH8, Q86WS8, Q8NBB4
    Related
    ENSP00000282326.1, ENST00000282326.6
    Conserved Domains (3) summary
    sd00017
    Location:294 → 314
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:35 → 122
    SCAN; SCAN domain
    pfam13465
    Location:306 → 331
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    58034025..58056502
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723149.3 → XP_006723212.1  zinc finger and SCAN domain-containing protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006723212.1

    Conserved Domains (3) summary
    sd00017
    Location:334 → 354
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:75 → 162
    SCAN; SCAN domain
    pfam13465
    Location:346 → 371
    zf-H2C2_2; Zinc-finger double domain

  2. XM_047438630.1 → XP_047294586.1  zinc finger and SCAN domain-containing protein 1 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    61130974..61155728
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320590.1 → XP_054176565.1  zinc finger and SCAN domain-containing protein 1 isoform X2

  2. XM_054320589.1 → XP_054176564.1  zinc finger and SCAN domain-containing protein 1 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NBB4.2 GenPept UniProtKB/Swiss-Prot:Q8NBB4

Gene LinkOut

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