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ZIK1 zinc finger protein interacting with K protein 1 [ Homo sapiens (human) ]

Gene ID: 284307, updated on 2-Nov-2024

Summary

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Official Symbol
ZIK1provided by HGNC
Official Full Name
zinc finger protein interacting with K protein 1provided by HGNC
Primary source
HGNC:HGNC:33104
See related
Ensembl:ENSG00000171649 AllianceGenome:HGNC:33104
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF762
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in thyroid (RPKM 2.1), testis (RPKM 1.9) and 24 other tissues See more
Orthologs
all
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Genomic context

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See ZIK1 in Genome Data Viewer
Location:
19q13.43
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (57584145..57593890)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (60681073..60690819)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58095513..58105258)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 550 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58070497-58071361 Neighboring gene uncharacterized LOC124904781 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:58071339-58072538 Neighboring gene zinc finger protein 416 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11076 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58095022-58095553 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15148 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15149 Neighboring gene zinc finger protein 530 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15150 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11077 Neighboring gene zinc finger protein 134

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Zik1, a transcriptional repressor that interacts with the heterogeneous nuclear ribonucleoprotein particle K protein. Denisenko ON, et al. J Biol Chem, 1996 Nov 1. PMID 8910362
  2. Cross-linking mass spectrometry discovers, evaluates, and corroborates structures and protein-protein interactions in the human cell. Bartolec TK, et al. Proc Natl Acad Sci U S A, 2023 Apr 25. PMID 37071682, Free PMC Article
  3. Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. Haenig C, et al. Cell Rep, 2020 Aug 18. PMID 32814053
  4. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Fasci D, et al. Mol Cell Proteomics, 2018 Oct. PMID 30021884, Free PMC Article
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC119699, MGC119700, MGC119701

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein interacting with ribonucleoprotein K
Names
zinc finger protein 762
zinc finger protein interacting with K protein 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001010879.4 → NP_001010879.2  zinc finger protein interacting with ribonucleoprotein K isoform 1

    See identical proteins and their annotated locations for NP_001010879.2

    Status: VALIDATED

    Source sequence(s)
    AC003682, AK092538, BC103958
    Consensus CDS
    CCDS33135.1
    UniProtKB/Swiss-Prot
    O43339, Q3SY51, Q3SY52, Q3SY53
    Related
    ENSP00000472867.1, ENST00000597850.2
    Conserved Domains (5) summary
    smart00349
    Location:27 → 68
    KRAB; krueppel associated box
    COG5048
    Location:269 → 449
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:381 → 401
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:27 → 66
    KRAB; KRAB box
    pfam13465
    Location:394 → 418
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001321145.2 → NP_001308074.1  zinc finger protein interacting with ribonucleoprotein K isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC003682, AK128340, BC103957, DB480028
    Consensus CDS
    CCDS82407.1
    UniProtKB/TrEMBL
    F5H435
    Related
    ENSP00000438487.1, ENST00000536878.6
    Conserved Domains (5) summary
    smart00349
    Location:14 → 55
    KRAB; krueppel associated box
    COG5048
    Location:256 → 436
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:368 → 388
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:14 → 53
    KRAB; KRAB box
    pfam13465
    Location:381 → 405
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001321146.2 → NP_001308075.1  zinc finger protein interacting with ribonucleoprotein K isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC003682, BC103957, BC103959, DB277510
    Consensus CDS
    CCDS82408.1
    UniProtKB/Swiss-Prot
    Q3SY52
    Related
    ENSP00000468937.1, ENST00000599456.1
    Conserved Domains (3) summary
    COG5048
    Location:214 → 394
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:326 → 346
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:339 → 363
    zf-H2C2_2; Zinc-finger double domain

  4. NM_001321147.2 → NP_001308076.1  zinc finger protein interacting with ribonucleoprotein K isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC003682, BC103957, DA101277, DN993640
    UniProtKB/Swiss-Prot
    Q3SY52
    Conserved Domains (2) summary
    COG5048
    Location:166 → 346
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:278 → 298
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    57584145..57593890
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526762.2 → XP_011525064.1  zinc finger protein interacting with ribonucleoprotein K isoform X2

    Conserved Domains (5) summary
    smart00349
    Location:8 → 49
    KRAB; krueppel associated box
    COG5048
    Location:250 → 430
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:362 → 382
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:8 → 47
    KRAB; KRAB box
    pfam13465
    Location:375 → 399
    zf-H2C2_2; Zinc-finger double domain

  2. XM_011526766.3 → XP_011525068.1  zinc finger protein interacting with ribonucleoprotein K isoform X4

    See identical proteins and their annotated locations for XP_011525068.1

    UniProtKB/Swiss-Prot
    Q3SY52
    Conserved Domains (3) summary
    COG5048
    Location:214 → 394
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:326 → 346
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:339 → 363
    zf-H2C2_2; Zinc-finger double domain

  3. XM_011526765.3 → XP_011525067.1  zinc finger protein interacting with ribonucleoprotein K isoform X3

    Conserved Domains (3) summary
    COG5048
    Location:233 → 413
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:345 → 365
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:358 → 382
    zf-H2C2_2; Zinc-finger double domain

  4. XM_011526761.2 → XP_011525063.1  zinc finger protein interacting with ribonucleoprotein K isoform X1

    Conserved Domains (4) summary
    COG5048
    Location:255 → 435
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:367 → 387
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:20 → 52
    KRAB; KRAB box
    pfam13465
    Location:380 → 404
    zf-H2C2_2; Zinc-finger double domain

  5. XM_011526767.4 → XP_011525069.1  zinc finger protein interacting with ribonucleoprotein K isoform X5

    See identical proteins and their annotated locations for XP_011525069.1

    UniProtKB/Swiss-Prot
    Q3SY52
    Conserved Domains (2) summary
    COG5048
    Location:166 → 346
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:278 → 298
    ZF_C2H2; C2H2 Zn finger [structural motif]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    60681073..60690819
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320585.1 → XP_054176560.1  zinc finger protein interacting with ribonucleoprotein K isoform X2

  2. XM_054320587.1 → XP_054176562.1  zinc finger protein interacting with ribonucleoprotein K isoform X4

  3. XM_054320586.1 → XP_054176561.1  zinc finger protein interacting with ribonucleoprotein K isoform X3

  4. XM_054320584.1 → XP_054176559.1  zinc finger protein interacting with ribonucleoprotein K isoform X1

  5. XM_054320588.1 → XP_054176563.1  zinc finger protein interacting with ribonucleoprotein K isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3SY52.1 GenPept UniProtKB/Swiss-Prot:Q3SY52

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