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PTGR3 prostaglandin reductase 3 [ Homo sapiens (human) ]

Gene ID: 284273, updated on 14-Nov-2024

Summary

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Official Symbol
PTGR3provided by HGNC
Official Full Name
prostaglandin reductase 3provided by HGNC
Primary source
HGNC:HGNC:28697
See related
Ensembl:ENSG00000180011 MIM:620604; AllianceGenome:HGNC:28697
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRG-3; ZADH2; PTGR-3
Summary
Predicted to enable 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity. Predicted to be involved in negative regulation of fat cell differentiation. Located in mitochondrion. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in placenta (RPKM 7.9), thyroid (RPKM 6.9) and 25 other tissues See more
Orthologs
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Genomic context

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See PTGR3 in Genome Data Viewer
Location:
18q22.3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (75195108..75209139, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (75424502..75438532, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (72907063..72921094, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904325 Neighboring gene uncharacterized LOC124904326 Neighboring gene uncharacterized LOC105376874 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:72882003-72882504 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:72882505-72883004 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:72916583-72917576 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:72920599-72921529 Neighboring gene Sharpr-MPRA regulatory region 3936 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9549 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr18:72947291-72948490 Neighboring gene teashirt zinc finger homeobox 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13506 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:72985503-72986004 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:72986005-72986504 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:72990985-72991486 Neighboring gene Sharpr-MPRA regulatory region 9768 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr18:73061340-73062286 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr18:73062287-73063231 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:73072069-73072610 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:73072611-73073151 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:73090414-73090914 Neighboring gene uncharacterized LOC105372200 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr18:73120415-73121614 Neighboring gene small integral membrane protein 21

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. [Mechanism of miRNA-3679 Inhibiting Downstream ZADH2-Target Genes to Promote Hepatocellular Carcinoma Cell Proliferation]. He JY, et al. Sichuan Da Xue Xue Bao Yi Xue Ban, 2022 Sep. PMID 36224673, Free PMC Article
  2. DNA Hypomethylation in Blood Links B3GALT4 and ZADH2 to Alzheimer's Disease. Madrid A, et al. J Alzheimers Dis, 2018. PMID 30372681, Free PMC Article
  3. Thermal proteome profiling identifies PIP4K2A and ZADH2 as off-targets of Polo-like kinase 1 inhibitor volasertib. Goroshchuk O, et al. FASEB J, 2021 Jul. PMID 34143546
  4. Prostaglandin reductase-3 negatively modulates adipogenesis through regulation of PPARγ activity. Yu YH, et al. J Lipid Res, 2013 Sep. PMID 23821743, Free PMC Article
  5. Genetic analysis of diabetic nephropathy on chromosome 18 in African Americans: linkage analysis and dense SNP mapping. McDonough CW, et al. Hum Genet, 2009 Dec. PMID 19690890, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. [Mechanism of miRNA-3679 Inhibiting Downstream ZADH2-Target Genes to Promote Hepatocellular Carcinoma Cell Proliferation].
    Title: [Mechanism of miRNA-3679 Inhibiting Downstream ZADH2-Target Genes to Promote Hepatocellular Carcinoma Cell Proliferation].
  2. Thermal proteome profiling identifies PIP4K2A and ZADH2 as off-targets of Polo-like kinase 1 inhibitor volasertib.
    Title: Thermal proteome profiling identifies PIP4K2A and ZADH2 as off-targets of Polo-like kinase 1 inhibitor volasertib.
  3. In patients with late-onset Alzheimer disease, a number of differentially methylated postitions were hypomethylated in ZADH2 compared with controls.
    Title: DNA Hypomethylation in Blood Links B3GALT4 and ZADH2 to Alzheimer's Disease.
  4. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC45594

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in mitochondrion HTP PubMed 
located_in peroxisome ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
prostaglandin reductase 3
Names
zinc binding alcohol dehydrogenase domain containing 2
zinc-binding alcohol dehydrogenase domain-containing protein 2
NP_001293022.1
NP_787103.1
XP_024306934.1
XP_054174512.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001306093.1 → NP_001293022.1  prostaglandin reductase 3 isoform 2

    See identical proteins and their annotated locations for NP_001293022.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC025105, AK302801, BU682476, BX647730
    Consensus CDS
    CCDS77198.1
    UniProtKB/Swiss-Prot
    Q8N4Q0
    Related
    ENSP00000440111.2, ENST00000537114.2
    Conserved Domains (1) summary
    cl16912
    Location:1 → 245
    MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family

  2. NM_175907.6 → NP_787103.1  prostaglandin reductase 3 isoform 1

    See identical proteins and their annotated locations for NP_787103.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC025105, BC018081, BU682476
    Consensus CDS
    CCDS12008.1
    UniProtKB/Swiss-Prot
    A8KA15, B4DZ91, Q8N4Q0
    UniProtKB/TrEMBL
    Q4G1C4
    Related
    ENSP00000323678.3, ENST00000322342.4
    Conserved Domains (1) summary
    cd08250
    Location:32 → 368
    Mgc45594_like; Mgc45594 gene product and other MDR family members

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    75195108..75209139 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451166.2 → XP_024306934.1  prostaglandin reductase 3 isoform X1

    Conserved Domains (1) summary
    cl16912
    Location:1 → 245
    MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    75424502..75438532 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054318537.1 → XP_054174512.1  prostaglandin reductase 3 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N4Q0.1 GenPept UniProtKB/Swiss-Prot:Q8N4Q0

Gene LinkOut

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