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TMEM105 TMEM105 long non-coding RNA [ Homo sapiens (human) ]

Gene ID: 284186, updated on 28-Oct-2024

Summary

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Official Symbol
TMEM105provided by HGNC
Official Full Name
TMEM105 long non-coding RNAprovided by HGNC
Primary source
HGNC:HGNC:26794
See related
Ensembl:ENSG00000185332 AllianceGenome:HGNC:26794
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be located in membrane. [provided by Alliance of Genome Resources, Oct 2024]
Expression
Low expression observed in reference dataset See more
Orthologs
all
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Genomic context

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See TMEM105 in Genome Data Viewer
Location:
17q25.3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (81311265..81330674, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (82223511..82242919, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (79285065..79304474, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904082 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:79273333-79273505 Neighboring gene CRISPRi-validated cis-regulatory element chr17.5937 Neighboring gene long intergenic non-protein coding RNA 482 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12962 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79291988-79292526 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79302243-79302814 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79302815-79303386 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79303387-79303956 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79305100-79305670 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79305671-79306241 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79313044-79313992 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:79319562-79319850 Neighboring gene regulator of early neurogenesis 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79322101-79322738 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79339241-79339828 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79339829-79340414 Neighboring gene uncharacterized LOC124904083

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Glycolysis-related lncRNA TMEM105 upregulates LDHA to facilitate breast cancer liver metastasis via sponging miR-1208. Han J, et al. Cell Death Dis, 2023 Feb 3. PMID 36737428, Free PMC Article
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Glycolysis-related lncRNA TMEM105 upregulates LDHA to facilitate breast cancer liver metastasis via sponging miR-1208.
    Title: Glycolysis-related lncRNA TMEM105 upregulates LDHA to facilitate breast cancer liver metastasis via sponging miR-1208.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Homology

Other Names

  • transmembrane protein 105

Clone Names

  • FLJ38792

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_165247.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC027601
    Related
    ENST00000650606.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    81311265..81330674 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    82223511..82242919 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_178520.3: Suppressed sequence

    Description
    NM_178520.3: This RefSeq was removed because it is now thought that this gene does not encode a protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N8V8.1 GenPept UniProtKB/Swiss-Prot:Q8N8V8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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