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MEIOC meiosis specific with coiled-coil domain [ Homo sapiens (human) ]

Gene ID: 284071, updated on 5-Mar-2024

Summary

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Official Symbol
MEIOCprovided by HGNC
Official Full Name
meiosis specific with coiled-coil domainprovided by HGNC
Primary source
HGNC:HGNC:26670
See related
Ensembl:ENSG00000180336 MIM:616934; AllianceGenome:HGNC:26670
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C17orf104
Summary
Predicted to be involved in several processes, including gamete generation; germline cell cycle switching, mitotic to meiotic cell cycle; and mRNA stabilization. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis (RPKM 25.4) See more
Orthologs
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Genomic context

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Location:
17q21.31
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (44656468..44677087)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (45510420..45531046)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (42733836..42753169)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr17:42634117-42634884 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:42635102-42636062 Neighboring gene MPRA-validated peak2866 silencer Neighboring gene frizzled class receptor 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:42664661-42665226 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:42675147-42675724 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:42684805-42685416 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12264 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8598 Neighboring gene long intergenic non-protein coding RNA 1180 Neighboring gene single-pass membrane protein with coiled-coil domains 4 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8599 Neighboring gene uncharacterized LOC105371792 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:42766877-42767466 Neighboring gene uncharacterized LOC124904010 Neighboring gene coiled-coil domain containing 43

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Implementation of meiosis prophase I programme requires a conserved retinoid-independent stabilizer of meiotic transcripts. Abby E, et al. Nat Commun, 2016 Jan 8. PMID 26742488, Free PMC Article
  2. TRIP12 ubiquitination of glucocerebrosidase contributes to neurodegeneration in Parkinson's disease. Seo BA, et al. Neuron, 2021 Dec 1. PMID 34644545, Free PMC Article
  3. RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy. Radaszkiewicz T, et al. Elife, 2021 Oct 27. PMID 34702444, Free PMC Article
  4. Generation and analysis of 280,000 human expressed sequence tags. Hillier LD, et al. Genome Res, 1996 Sep. PMID 8889549
  5. Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation. May DG, et al. Cells, 2020 Apr 25. PMID 32344865, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Meioc is expressed in germ cells during meiotic prophase I. MEIOC prevents meiotic transcript degradation and interacts with an RNA helicase that binds numerous meiotic mRNAs.
    Title: Implementation of meiosis prophase I programme requires a conserved retinoid-independent stabilizer of meiotic transcripts.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ35848, FLJ40428, MGC43301

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in chromosome organization involved in meiotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in double-strand break repair IEA
Inferred from Electronic Annotation
more info
  
involved_in female meiosis I IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in germline cell cycle switching, mitotic to meiotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mRNA stabilization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in male meiosis I IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in metaphase chromosome alignment IEA
Inferred from Electronic Annotation
more info
  
involved_in oocyte development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in spermatid development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in synaptonemal complex assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
meiosis-specific coiled-coil domain-containing protein MEIOC
Names
meiosis-specific with coiled-coil domain protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145080.3 → NP_001138552.2  meiosis-specific coiled-coil domain-containing protein MEIOC

    See identical proteins and their annotated locations for NP_001138552.2

    Status: VALIDATED

    Source sequence(s)
    AA205120, AC091152, BC041481, DB460166, DV080633
    Consensus CDS
    CCDS45703.2
    UniProtKB/Swiss-Prot
    A2RUB1, B4DXJ2, B5MD93, B9EGQ6, C4AM97, Q4G0Y1, Q8IVZ7, Q8NA45
    Related
    ENSP00000386452.1, ENST00000409122.7
    Conserved Domains (1) summary
    pfam15189
    Location:747 → 912
    DUF4582; Domain of unknown function (DUF4582)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    44656468..44677087
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257236.4 → XP_005257293.1  meiosis-specific coiled-coil domain-containing protein MEIOC isoform X1

    Conserved Domains (1) summary
    pfam15189
    Location:747 → 912
    DUF4582; Domain of unknown function (DUF4582)

  2. XM_047435802.1 → XP_047291758.1  meiosis-specific coiled-coil domain-containing protein MEIOC isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    45510420..45531046
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054315781.1 → XP_054171756.1  meiosis-specific coiled-coil domain-containing protein MEIOC isoform X1

  2. XM_054315782.1 → XP_054171757.1  meiosis-specific coiled-coil domain-containing protein MEIOC isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001033659.2: Suppressed sequence

    Description
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2RUB1.3 GenPept UniProtKB/Swiss-Prot:A2RUB1

Gene LinkOut

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