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VMO1 vitelline membrane outer layer 1 homolog [ Homo sapiens (human) ]

Gene ID: 284013, updated on 14-Nov-2024

Summary

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Official Symbol
VMO1provided by HGNC
Official Full Name
vitelline membrane outer layer 1 homologprovided by HGNC
Primary source
HGNC:HGNC:30387
See related
Ensembl:ENSG00000182853 AllianceGenome:HGNC:30387
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ERGA6350; PRO21055
Summary
Located in extracellular exosome. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in spleen (RPKM 5.3), lung (RPKM 3.3) and 24 other tissues See more
Orthologs
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Genomic context

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See VMO1 in Genome Data Viewer
Location:
17p13.2
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (4785285..4786364, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (4674933..4676011, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (4688580..4689659, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene C-X-C motif chemokine ligand 16 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:4642642-4643546 Neighboring gene zinc finger MYND-type containing 15 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:4667359-4667521 Neighboring gene transmembrane 4 L six family member 5 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8044 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11548 Neighboring gene glycolipid transfer protein domain containing 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:4699218-4699816 Neighboring gene proteasome 20S subunit beta 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Methylation and transcriptome analyses construct a prognostic model and reveal the suppressor role of VMO1 in lung adenocarcinoma. Wang L, et al. Cell Signal, 2024 Oct. PMID 39053673
  2. Analysis and comparison of proteomic profiles of tear fluid from human, cow, sheep, and camel eyes. Shamsi FA, et al. Invest Ophthalmol Vis Sci, 2011 Nov 25. PMID 22025569
  3. Signal peptide prediction based on analysis of experimentally verified cleavage sites. Zhang Z, et al. Protein Sci, 2004 Oct. PMID 15340161, Free PMC Article
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Clark HF, et al. Genome Res, 2003 Oct. PMID 12975309, Free PMC Article
  5. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Methylation and transcriptome analyses construct a prognostic model and reveal the suppressor role of VMO1 in lung adenocarcinoma.
    Title: Methylation and transcriptome analyses construct a prognostic model and reveal the suppressor role of VMO1 in lung adenocarcinoma.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

Homology

Clone Names

  • MGC125880, MGC125881

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
vitelline membrane outer layer protein 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001144939.2 → NP_001138411.1  vitelline membrane outer layer protein 1 homolog isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site at the 3' end of exon 2, compared to variant 1. This difference results in a frameshift and a protein (isoform 2) with a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BI836994, CD367473
    Consensus CDS
    CCDS45587.1
    UniProtKB/Swiss-Prot
    Q7Z5L0
    Related
    ENSP00000408166.2, ENST00000441199.2
    Conserved Domains (1) summary
    cd00220
    Location:35 → 106
    VMO-I; Vitelline membrane outer layer protein I (VMO-I) domain, VMO-I is one of the proteins found in the outer layer of the vitelline membrane of poultry eggs; VMO-I, lysozyme, and VMO-II are tightly bound to ovomucin; this complex forms the backbone of the ...

  2. NM_001144940.2 → NP_001138412.1  vitelline membrane outer layer protein 1 homolog isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site at the 3' end of exon 2, compared to variant 1. This difference results in a frameshift and a protein (isoform 3) with a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC104195, BI836994, CD367284
    Consensus CDS
    CCDS45586.1
    UniProtKB/Swiss-Prot
    Q7Z5L0
    Related
    ENSP00000390450.2, ENST00000416307.6
    Conserved Domains (1) summary
    cd00220
    Location:35 → 91
    VMO-I; Vitelline membrane outer layer protein I (VMO-I) domain, VMO-I is one of the proteins found in the outer layer of the vitelline membrane of poultry eggs; VMO-I, lysozyme, and VMO-II are tightly bound to ovomucin; this complex forms the backbone of the ...

  3. NM_001144941.2 → NP_001138413.1  vitelline membrane outer layer protein 1 homolog isoform 4 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an exon in the coding region, compared to variant 1. This difference results in a frameshift and a protein (isoform 4) with a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BI836994, CD367473
    Consensus CDS
    CCDS45585.1
    UniProtKB/Swiss-Prot
    Q7Z5L0
    Related
    ENSP00000346133.4, ENST00000354194.4
    Conserved Domains (1) summary
    cd00220
    Location:35 → 65
    VMO-I; Vitelline membrane outer layer protein I (VMO-I) domain, VMO-I is one of the proteins found in the outer layer of the vitelline membrane of poultry eggs; VMO-I, lysozyme, and VMO-II are tightly bound to ovomucin; this complex forms the backbone of the ...

  4. NM_182566.3 → NP_872372.1  vitelline membrane outer layer protein 1 homolog isoform 1 precursor

    See identical proteins and their annotated locations for NP_872372.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BC104195, CD367284
    Consensus CDS
    CCDS11055.1
    UniProtKB/Swiss-Prot
    C9JQ15, E9PAU9, E9PGP4, Q3SXP1, Q7Z5L0, Q8IUY1
    Related
    ENSP00000328397.5, ENST00000328739.6
    Conserved Domains (1) summary
    pfam03762
    Location:36 → 200
    VOMI; Vitelline membrane outer layer protein I (VOMI)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    4785285..4786364 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    4674933..4676011 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7Z5L0.1 GenPept UniProtKB/Swiss-Prot:Q7Z5L0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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