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GREP1 glycine rich extracellular protein 1 [ Homo sapiens (human) ]

Gene ID: 283875, updated on 5-Mar-2024

Summary

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Official Symbol
GREP1provided by HGNC
Official Full Name
glycine rich extracellular protein 1provided by HGNC
Primary source
HGNC:HGNC:27549
See related
Ensembl:ENSG00000262152 AllianceGenome:HGNC:27549
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
G029442; LINC00514; LA16c-380H5.1; LA16c-380H5.3
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

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See GREP1 in Genome Data Viewer
Location:
16p13.3
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (2988262..3002011)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (3014944..3028691)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (3038263..3052012)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7089 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3015093-3016052 Neighboring gene kringle containing transmembrane protein 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3018331-3019320 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7092 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7093 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7094 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7095 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3021603-3022419 Neighboring gene progestin and adipoQ receptor family member 4 Neighboring gene protein kinase, membrane associated tyrosine/threonine 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3029137-3030013 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3030014-3030889 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3030890-3031766 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3032811-3033312 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7098 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:3033737-3033923 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3037455-3038406 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3038407-3039356 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3043721-3044222 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3045542-3046514 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3048182-3048682 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3048683-3049183 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3051481-3052017 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr16:3053764-3054722 Neighboring gene Sharpr-MPRA regulatory region 8596 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3057599-3058558 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3058559-3059516 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3061783-3062608 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:3064184-3064351 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3065208-3065772 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:3066992-3067588 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:3067589-3068185 Neighboring gene claudin 9 Neighboring gene claudin 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. LINC00514 facilitates cell proliferation, migration, invasion, and epithelial-mesenchymal transition in non-small cell lung cancer by acting on the Wnt/β-catenin signaling pathway. Zhu Y, et al. Bioengineered, 2022 May. PMID 35653786, Free PMC Article
  2. Noncanonical open reading frames encode functional proteins essential for cancer cell survival. Prensner JR, et al. Nat Biotechnol, 2021 Jun. PMID 33510483, Free PMC Article
  3. Long noncoding RNA LINC00514 accelerates pancreatic cancer progression by acting as a ceRNA of miR-28-5p to upregulate Rap1b expression. Han Q, et al. J Exp Clin Cancer Res, 2020 Aug 8. PMID 32771045, Free PMC Article
  4. LINC00514 drives osteosarcoma progression through sponging microRNA-708 and consequently increases URGCP expression. Yu D, et al. Aging (Albany NY), 2020 Apr 23. PMID 32325430, Free PMC Article
  5. The long noncoding RNA landscape of neuroendocrine prostate cancer and its clinical implications. Ramnarine VR, et al. Gigascience, 2018 Jun 1. PMID 29757368, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LINC00514 facilitates cell proliferation, migration, invasion, and epithelial-mesenchymal transition in non-small cell lung cancer by acting on the Wnt/beta-catenin signaling pathway.
    Title: LINC00514 facilitates cell proliferation, migration, invasion, and epithelial-mesenchymal transition in non-small cell lung cancer by acting on the Wnt/β-catenin signaling pathway.
  2. LINC00514 promotes lipogenesis and tumor progression in esophageal squamous cell carcinoma by sponging miR378a5p to enhance SPHK1 expression.
    Title: LINC00514 promotes lipogenesis and tumor progression in esophageal squamous cell carcinoma by sponging miR‑378a‑5p to enhance SPHK1 expression.
  3. LINC00514 promotes gastric cancer cell growth and EMT progression via miR-204-3p/KRAS.
    Title: LINC00514 promotes gastric cancer cell growth and EMT progression via miR-204-3p/KRAS.
  4. Long noncoding RNA LINC00514 accelerates pancreatic cancer progression by acting as a ceRNA of miR-28-5p to upregulate Rap1b expression.
    Title: Long noncoding RNA LINC00514 accelerates pancreatic cancer progression by acting as a ceRNA of miR-28-5p to upregulate Rap1b expression.
  5. LINC00514 drives osteosarcoma progression through sponging microRNA-708 and consequently increases URGCP expression.
    Title: LINC00514 drives osteosarcoma progression through sponging microRNA-708 and consequently increases URGCP expression.
  6. LINC00514 promoted CDC23 expression via restraining miR-204-3p activity, leading to papillary thyroid cancer progression.
    Title: Silencing of lncRNA LINC00514 inhibits the malignant behaviors of papillary thyroid cancer through miR-204-3p/CDC23 axis.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Homology

Clone Names

  • FLJ46402

General protein information

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Preferred Names
glycine-rich extracellular protein 1
Names
long intergenic non-protein coding RNA 514

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001396456.1 → NP_001383385.1  glycine-rich extracellular protein 1 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC004233

  2. NM_001396457.1 → NP_001383386.1  glycine-rich extracellular protein 1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC004233
    UniProtKB/Swiss-Prot
    A0A0J9YXV3

  3. NM_001396458.1 → NP_001383387.1  glycine-rich extracellular protein 1 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC004233
    Related
    ENSP00000488558.1, ENST00000573315.2

  4. NM_001396459.1 → NP_001383388.1  glycine-rich extracellular protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC004233

  5. NM_001396460.1 → NP_001383389.1  glycine-rich extracellular protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC004233

  6. NM_001396461.1 → NP_001383390.1  glycine-rich extracellular protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC004233

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    2988262..3002011
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047433975.1 → XP_047289931.1  glycine-rich extracellular protein 1 isoform X15

  2. XM_047433976.1 → XP_047289932.1  glycine-rich extracellular protein 1 isoform X15

  3. XM_047433969.1 → XP_047289925.1  glycine-rich extracellular protein 1 isoform X9

  4. XM_047433960.1 → XP_047289916.1  glycine-rich extracellular protein 1 isoform X1

  5. XM_047433963.1 → XP_047289919.1  glycine-rich extracellular protein 1 isoform X4

  6. XM_047433968.1 → XP_047289924.1  glycine-rich extracellular protein 1 isoform X8

  7. XM_047433970.1 → XP_047289926.1  glycine-rich extracellular protein 1 isoform X10

  8. XM_047433971.1 → XP_047289927.1  glycine-rich extracellular protein 1 isoform X11

  9. XM_047433966.1 → XP_047289922.1  glycine-rich extracellular protein 1 isoform X7

  10. XM_047433972.1 → XP_047289928.1  glycine-rich extracellular protein 1 isoform X12

  11. XM_047433973.1 → XP_047289929.1  glycine-rich extracellular protein 1 isoform X13

  12. XM_047433961.1 → XP_047289917.1  glycine-rich extracellular protein 1 isoform X2

  13. XM_047433974.1 → XP_047289930.1  glycine-rich extracellular protein 1 isoform X14

  14. XM_047433965.1 → XP_047289921.1  glycine-rich extracellular protein 1 isoform X6

  15. XM_047433964.1 → XP_047289920.1  glycine-rich extracellular protein 1 isoform X5

  16. XM_047433962.1 → XP_047289918.1  glycine-rich extracellular protein 1 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    3014944..3028691
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054380126.1 → XP_054236101.1  glycine-rich extracellular protein 1 isoform X15

  2. XM_054380121.1 → XP_054236096.1  glycine-rich extracellular protein 1 isoform X9

  3. XM_054380114.1 → XP_054236089.1  glycine-rich extracellular protein 1 isoform X1

  4. XM_054380117.1 → XP_054236092.1  glycine-rich extracellular protein 1 isoform X4

  5. XM_054380122.1 → XP_054236097.1  glycine-rich extracellular protein 1 isoform X10

  6. XM_054380123.1 → XP_054236098.1  glycine-rich extracellular protein 1 isoform X11

  7. XM_054380120.1 → XP_054236095.1  glycine-rich extracellular protein 1 isoform X7

  8. XM_054380124.1 → XP_054236099.1  glycine-rich extracellular protein 1 isoform X12

  9. XM_054380125.1 → XP_054236100.1  glycine-rich extracellular protein 1 isoform X13

  10. XM_054380115.1 → XP_054236090.1  glycine-rich extracellular protein 1 isoform X2

  11. XM_054380119.1 → XP_054236094.1  glycine-rich extracellular protein 1 isoform X6

  12. XM_054380118.1 → XP_054236093.1  glycine-rich extracellular protein 1 isoform X5

  13. XM_054380116.1 → XP_054236091.1  glycine-rich extracellular protein 1 isoform X3

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_033861.1: Suppressed sequence

    Description
    NR_033861.1: This RefSeq was removed because currently there is insufficient support for the transcript.

  2. NR_110947.1: Suppressed sequence

    Description
    NR_110947.1: This RefSeq was removed because currently there is insufficient support for the transcript.

  3. NR_110948.1: Suppressed sequence

    Description
    NR_110948.1: This RefSeq was removed because currently there is insufficient support for the transcript.

  4. NR_110949.1: Suppressed sequence

    Description
    NR_110949.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0J9YXV3.1 GenPept UniProtKB/Swiss-Prot:A0A0J9YXV3

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