U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

GPR137C G protein-coupled receptor 137C [ Homo sapiens (human) ]

Gene ID: 283554, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
GPR137Cprovided by HGNC
Official Full Name
G protein-coupled receptor 137Cprovided by HGNC
Primary source
HGNC:HGNC:25445
See related
Ensembl:ENSG00000180998 AllianceGenome:HGNC:25445
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TM7SF1L2
Summary
Predicted to be involved in positive regulation of TORC1 signaling. Located in lysosomal membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 7.8), testis (RPKM 1.4) and 8 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
14q22.1
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (52552836..52637713)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (46760682..46845552)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (53019554..53104431)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:52780821-52781380 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8386 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8387 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8388 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8389 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8390 Neighboring gene prostaglandin E receptor 2 Neighboring gene thioredoxin domain containing 16 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5744 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5745 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:53034445-53035160 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:53035161-53035876 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:53062685-53063186 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr14:53130319-53130927 Neighboring gene endoplasmic reticulum oxidoreductase 1 alpha Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:53161801-53162302 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8392 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8393 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8394 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8395 Neighboring gene proteasome 26S subunit, ATPase 6

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The lysosomal GPCR-like protein GPR137B regulates Rag and mTORC1 localization and activity. Gan L, et al. Nat Cell Biol, 2019 May. PMID 31036939, Free PMC Article
  2. The G protein-coupled receptor repertoires of human and mouse. Vassilatis DK, et al. Proc Natl Acad Sci U S A, 2003 Apr 15. PMID 12679517, Free PMC Article
  3. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. Eeles RA, et al. Nat Genet, 2013 Apr. PMID 23535732, Free PMC Article
  4. Transcriptome analysis of human gastric cancer. Oh JH, et al. Mamm Genome, 2005 Dec. PMID 16341674
  5. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. Fei T, et al. Proc Natl Acad Sci U S A, 2017 Jun 27. PMID 28611215, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • DKFZp762F0713

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in positive regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
integral membrane protein GPR137C
Names
G protein-coupled receptor TM7SF1L2
transmembrane 7 superfamily member 1-like 2 protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099652.2 → NP_001093122.1  integral membrane protein GPR137C isoform 2

    See identical proteins and their annotated locations for NP_001093122.1

    Status: VALIDATED

    Source sequence(s)
    AK123953, AL133453, AL157971, AW470753, BM842962, BX647179
    Consensus CDS
    CCDS45106.1
    UniProtKB/Swiss-Prot
    Q86SM2, Q8N3F9
    UniProtKB/TrEMBL
    H0YFL6
    Related
    ENSP00000315106.6, ENST00000321662.11

  2. NM_001353361.2 → NP_001340290.1  integral membrane protein GPR137C isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL133453, AL157971, AL834372
    UniProtKB/TrEMBL
    H0YFL6
    Related
    ENSP00000439165.2, ENST00000542169.6

RNA

  1. NR_148417.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon and contains another alternate exon compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AL133453, AL157971

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    52552836..52637713
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047431281.1 → XP_047287237.1  integral membrane protein GPR137C isoform X4

  2. XM_047431280.1 → XP_047287236.1  integral membrane protein GPR137C isoform X2

  3. XM_024449541.2 → XP_024305309.1  integral membrane protein GPR137C isoform X3

  4. XM_047431279.1 → XP_047287235.1  integral membrane protein GPR137C isoform X1

RNA

  1. XR_007064006.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    46760682..46845552
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054375881.1 → XP_054231856.1  integral membrane protein GPR137C isoform X4

  2. XM_054375879.1 → XP_054231854.1  integral membrane protein GPR137C isoform X2

  3. XM_054375880.1 → XP_054231855.1  integral membrane protein GPR137C isoform X3

  4. XM_054375878.1 → XP_054231853.1  integral membrane protein GPR137C isoform X1

RNA

  1. XR_008488858.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N3F9.2 GenPept UniProtKB/Swiss-Prot:Q8N3F9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous