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NPBWR1 neuropeptides B and W receptor 1 [ Homo sapiens (human) ]

Gene ID: 2831, updated on 11-Apr-2024

Summary

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Official Symbol
NPBWR1provided by HGNC
Official Full Name
neuropeptides B and W receptor 1provided by HGNC
Primary source
HGNC:HGNC:4522
See related
Ensembl:ENSG00000288611 MIM:600730; AllianceGenome:HGNC:4522
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPR7
Summary
Predicted to enable G protein-coupled receptor activity and neuropeptide binding activity. Involved in G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in neuron projection. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
8q11.23
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (52939182..52943734)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (53315605..53320157)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (53851742..53856294)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375835 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:53676283-53677482 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27349 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:53764919-53765152 Neighboring gene uncharacterized LOC107986943 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:53851917-53852548 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:53852549-53853180 Neighboring gene NANOG hESC enhancer GRCh37_chr8:53883082-53883583 Neighboring gene E3 ubiquitin-protein ligase RING2-like Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:53930926-53931660 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:53931661-53932394 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27350 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:54055436-54056635 Neighboring gene uncharacterized LOC105375836 Neighboring gene EI24 pseudogene 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Frequency of the GPR7 Tyr135Phe allelic variant in lean and obese subjects. Pelosini C, et al. J Endocrinol Invest, 2013 Oct. PMID 23563248
  2. A single nucleotide polymorphism of the neuropeptide B/W receptor-1 gene influences the evaluation of facial expressions. Watanabe N, et al. PLoS One, 2012. PMID 22545105, Free PMC Article
  3. Schwann cell overexpression of the GPR7 receptor in inflammatory and painful neuropathies. Zaratin PF, et al. Mol Cell Neurosci, 2005 Jan. PMID 15607941
  4. Discovery and validation of 3 novel DNA methylation markers of prostate cancer prognosis. Cottrell S, et al. J Urol, 2007 May. PMID 17437806
  5. The cloning and chromosomal mapping of two novel human opioid-somatostatin-like receptor genes, GPR7 and GPR8, expressed in discrete areas of the brain. O'Dowd BF, et al. Genomics, 1995 Jul 1. PMID 7590751

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. screening of GPR7 gene mutations among lean and obese subjects revealed a Tyr135Phe allelic variant that is fairly common in the study population. This variant is unlikely to cause a functional derangement of the receptor
    Title: Frequency of the GPR7 Tyr135Phe allelic variant in lean and obese subjects.
  2. hypermethylation of HIST1H4F, PCDHGB6, NPBWR1, ALX1, and HOXA9 was significantly associated with shorter survival in stage 1 Non-small-cell lung cancer
    Title: A prognostic DNA methylation signature for stage I non-small-cell lung cancer.
  3. A single nucleotide polymorphism of NPBWR1 changed the receptor function of this molecule at the cellular level, and, at the behavioral level, could influence personality difference in the context of social interaction.
    Title: A single nucleotide polymorphism of the neuropeptide B/W receptor-1 gene influences the evaluation of facial expressions.
  4. distribution in central nervous system and peripheral tissues with precursor peptides
    Title: Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8.
  5. Expressed in the zona glomerulosa and zona fasciculata-reticularis ( cells of the human adrenal cortex.
    Title: G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades.
  6. neuropeptide B, a neuropeptide modified with bromine is an endogenous ligand for GPR7
    Title: Identification of a neuropeptide modified with bromine as an endogenous ligand for GPR7.
  7. methylation of the GPR7 is significantly associated with prostate cancer prognosis.
    Title: Discovery and validation of 3 novel DNA methylation markers of prostate cancer prognosis.
  8. These results suggest a relationship between the pathogenesis of inflammatory/immune-mediated neuropathies, GPR7 receptor expression, and pain transmission.
    Title: Schwann cell overexpression of the GPR7 receptor in inflammatory and painful neuropathies.
  9. characterization of a family of endogenous neuropeptide ligands for this G protein-coupled receptor
    Title: Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC129755

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled opioid receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables neuropeptide receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled opioid receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chemical synaptic transmission TAS
Traceable Author Statement
more info
 PubMed 
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IC
Inferred by Curator
more info
 PubMed 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
neuropeptides B/W receptor type 1
Names
G-protein coupled receptor 7
neuropeptide B/W receptor 1
neuropeptides B/W receptor 1
opioid-somatostatin-like receptor 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005285.5 → NP_005276.2  neuropeptides B/W receptor type 1

    See identical proteins and their annotated locations for NP_005276.2

    Status: VALIDATED

    Source sequence(s)
    AC087348
    Consensus CDS
    CCDS6151.1
    UniProtKB/Swiss-Prot
    P48145, Q6NTC7
    UniProtKB/TrEMBL
    H9NIL7
    Related
    ENSP00000501711.1, ENST00000674939.1
    Conserved Domains (1) summary
    cd15087
    Location:47 → 318
    7tmA_NPBWR; neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    52939182..52943734
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    53315605..53320157
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P48145.2 GenPept UniProtKB/Swiss-Prot:P48145

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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