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NEWENTRY Record to support submission of GeneRIFs for a gene not in Gene (Escherichia coli O157:H7 strain Sakai). [ Escherichia coli O157:H7 str. Sakai ]

Gene ID: 2829861, updated on 25-Jan-2023

Summary

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Gene symbol
NEWENTRY
Gene description
Record to support submission of GeneRIFs for a gene not in Gene (Escherichia coli O157:H7 strain Sakai).
Gene type
other
Organism
Escherichia coli O157:H7 str. Sakai
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
NEWENTRY
NEW
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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Under oxygen-limited conditions, DicF enhances global expression of the EHEC type three secretion system, which is a key virulence factor required for host colonization, through the transcriptional activator PchA
    Title: The sRNA DicF integrates oxygen sensing to enhance enterohemorrhagic Escherichia coli virulence via distinctive RNA control mechanisms.
  2. AtaT-AtaR proteins form a heterohexameric [AtaT-(AtaR4)-AtaT] complex, where two V-shaped AtaR dimers bridge two AtaT molecules. The N-terminal region of AtaR is required for its dimerization, and the C-terminal region of AtaR interacts with AtaT. AtaT alone forms a dimer in solution, which is enzymatically active. AtaR represses AtaT activity by preventing it from forming an active dimer. [AtaT, AtaR]
    Title: Crystal Structure of the Enterohemorrhagic Escherichia coli AtaT-AtaR Toxin-Antitoxin Complex.
  3. Data support the proposal that Slp directly contributes to initial adherence, with the pIgR protein as its proposed receptor. [Slp]
    Title: The Escherichia coli O157:H7 carbon starvation-inducible lipoprotein Slp contributes to initial adherence in vitro via the human polymeric immunoglobulin receptor.
  4. Multiple copies of small regulatory RNA (sRNA), Esr41 abolishe the locus of enterocyte effacement (LEE) expression and reduces Enterohaemorrhagic Escherichia coli (EHEC) adhesion to host cells. Esr41 activates the expression of flagellar Class 3 genes by indirectly inducing the transcription of the sigma factor for flagellar synthesis. Esr41 plays important roles in inverse regulation of LEE and flagellar gene expression.
    Title: Small RNA Esr41 inversely regulates expression of LEE and flagellar genes in enterohaemorrhagic Escherichia coli.
  5. Genes located in the locus of enterocyte effacement (LEE) pathogenicity island were significantly upregulated, whereas expression of flagella-related genes was significantly reduced in the csrA::kan mutant. [CsrA]
    Title: Global effect of CsrA on gene expression in enterohemorrhagic Escherichia coli O157:H7.
  6. StcE reduced the inner mucus layer and thereby promoted Enterohaemorrhagic Escherichia coli access and binding to the epithelium in vitro and ex vivo
    Title: The StcE metalloprotease of enterohaemorrhagic Escherichia coli reduces the inner mucus layer and promotes adherence to human colonic epithelium ex vivo.
  7. NleL-induced JNK ubiquitylation, particularly mono-ubiquitylation at the Lys 68 residue of JNK, impairs JNK's interaction with an upstream kinase MKK7, thus disrupting JNK phosphorylation and activation.[ NleL]
    Title: Bacterial effector NleL promotes enterohemorrhagic E. coli-induced attaching and effacing lesions by ubiquitylating and inactivating JNK.
  8. these data reveal that EspFU of Enteropathogenic and enterohemorrhagic Escherichia coli enhances epithelial colonization by increasing actin-based motility and promoting an efficient method of cell-to-cell transmission.
    Title: Extracellular motility and cell-to-cell transmission of enterohemorrhagic E. coli is driven by EspFU-mediated actin assembly.
  9. Study reports the crystal structure of MpaA. The asymmetric unit consists of two protein molecules and each monomer represents the common alpha/beta fold of metallocarboxypeptidases. The Tyr133-Asp143 loop appears to mediate the entrance and binding of the substrate into the active groove. [MpaA]
    Title: Crystal Structure of Murein-Tripeptide Amidase MpaA from Escherichia coli O157 at 2.6 Å Resolution.
  10. Data suggest that enteropathogenic Escherichia coli down-regulates host immune response via NieA which suppresses macrophage inflammasome activity through targeting of NLRP3 (cryopyrin). [NleA; non-LEE-encoded effector A]
    Title: Enteropathogenic Escherichia coli Uses NleA to Inhibit NLRP3 Inflammasome Activation.
Submit: New GeneRIF Correction See all GeneRIFs (31)

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