HGF hepatocyte growth factor [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: HGFprovided by VGNC
Official Full Name: hepatocyte growth factorprovided by VGNC
Primary source: VGNC:VGNC:29834
See related: Ensembl:ENSBTAG00000017664
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	4	NC_037331.1 (38928997..39014317)

Chromosome 4 - NC_037331.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results indicate that expression and production of HGF are regulated in a species-specific adipogenic differentiation-dependent manner and suggest that the decrease in HGF mRNA in mouse differentiated adipocytes is, at least in part, mediated by differentiation-dependent loss of its stability.
Title: Species-specific control of hepatocyte growth factor expression and production in adipocytes in a differentiation-dependent manner.
Results confirm the prodevelopmental actions of activin A and indicate that CTGF may also function as an embryokine by regulating the number of ICM cells in the blastocyst and altering gene expression. Low concentrations of HGF were inhibitory to development.
Title: Actions of activin A, connective tissue growth factor, hepatocyte growth factor and teratocarcinoma-derived growth factor 1 on the development of the bovine preimplantation embryo.
SNPs within bovine HGF gene were significantly associated with growth traits. This will provide a background for application of bovine HGF gene in the selection program in Chinese cattle.
Title: SNPs of bovine HGF gene and their association with growth traits in Nanyang cattle.
Treatment of the bovine satellite cells (BSC) with ephrin-A5 causes a reduction in velocity with a concomitant increase in directed migration. Treatment of BSC with hepatocyte growth factor had no immediate effect on cell motility or migration.
Title: Ephrin-A5 promotes bovine muscle progenitor cell migration before mitotic activation.
HGF transiently increases gene transcription of angiotensin-converting enzyme
Title: Hepatocyte growth factor regulates angiotensin converting enzyme expression.

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General gene information

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Markers

Hgf (e-PCR), detects polymorphism
- UniSTS:256371

Hgf (e-PCR), detects polymorphism
- UniSTS:143342

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in hepatocyte growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: hepatocyte growth factor

Names: SF; hepapoietin A; hepatopoeitin-A; hepatopoietin-A; scatter factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001031751.2 → NP_001026921.1 hepatocyte growth factor precursor

See identical proteins and their annotated locations for NP_001026921.1

Status: PROVISIONAL

Source sequence(s)

AB110822

UniProtKB/Swiss-Prot

Q76BS1

UniProtKB/TrEMBL

A0A1L3G6L5, A0A3Q1LSS6

Related

ENSBTAP00000023490.5, ENSBTAT00000023490.6

Conserved Domains (5) summary

smart00020
Location:494 → 718

Tryp_SPc; Trypsin-like serine protease

smart00130
Location:210 → 288

KR; Kringle domain

cd00108
Location:302 → 384

KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...

cd00129
Location:40 → 122

PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...

cd00190
Location:495 → 721

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037331.1 Reference ARS-UCD2.0 Primary Assembly

Range

38928997..39014317

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024990489.2 → XP_024846257.1 hepatocyte growth factor isoform X4

Conserved Domains (2) summary

smart00130
Location:126 → 208

KR; Kringle domain

cd00129
Location:40 → 122

PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
XM_005205314.5 → XP_005205371.1 hepatocyte growth factor isoform X1

See identical proteins and their annotated locations for XP_005205371.1

UniProtKB/TrEMBL

A0A3Q1LSS6, F1MZD6

Conserved Domains (4) summary

smart00020
Location:494 → 718

Tryp_SPc; Trypsin-like serine protease

smart00130
Location:210 → 288

KR; Kringle domain

cd00108
Location:302 → 384

KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...

cd00129
Location:40 → 122

PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
XM_005205315.5 → XP_005205372.3 hepatocyte growth factor isoform X2

UniProtKB/TrEMBL

A0A3Q1LSS6

Conserved Domains (5) summary

smart00020
Location:489 → 713

Tryp_SPc; Trypsin-like serine protease

smart00130
Location:205 → 283

KR; Kringle domain

cd00108
Location:297 → 379

KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...

cd00129
Location:40 → 122

PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...

cd00190
Location:490 → 716

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_059885413.1 → XP_059741396.1 hepatocyte growth factor isoform X3