PCK1 phosphoenolpyruvate carboxykinase 1 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: PCK1provided by VGNC
Official Full Name: phosphoenolpyruvate carboxykinase 1provided by VGNC
Primary source: VGNC:VGNC:32631
See related: Ensembl:ENSBTAG00000001936
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: PPCK1
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	13	NC_037340.1 (58609020..58615146, complement)

Chromosome 13 - NC_037340.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037340.1 Chromosome 13 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification of promoter response elements that mediate propionate induction of bovine cytosolic phosphoenolpyruvate carboxykinase (PCK1) gene transcription.
Title: Identification of promoter response elements that mediate propionate induction of bovine cytosolic phosphoenolpyruvate carboxykinase (PCK1) gene transcription.
GW501516-activated PPARd maintained the correlation between lipolysis and lipogenesis by enhancing PEPCK and CPT1 to improve bovine embryo quality.
Title: The PPARδ Agonist GW501516 Improves Lipolytic/Lipogenic Balance through CPT1 and PEPCK during the Development of Pre-Implantation Bovine Embryos.
Collectively, the identified 3'-untranslated-region SNP variant highlights the importance of PCK1 in the fecundity of Holstein bulls, and implicates a role for bta-miR-26a in regulating PCK1 abundance.
Title: PCK1 is negatively regulated by bta-miR-26a, and a single-nucleotide polymorphism in the 3' untranslated region is involved in semen quality and longevity of Holstein bulls.
Expression of cytosolic PEPCK mRNA is transiently increased during early lactation, indicating that enhanced hepatic gluconeogenesis during lactation may be tied to enhanced capacity for cytosolic formation of phosphoenolpyruvate.
Title: Cloning and characterization of bovine cytosolic and mitochondrial PEPCK during transition to lactation.

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General gene information

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Markers

MARC_5813-5814:997299323:1 (e-PCR)
- UniSTS:269580

D1S3698 (e-PCR)
- UniSTS:474276

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables manganese ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables phosphoenolpyruvate carboxykinase (GTP) activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to dexamethasone stimulus	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cellular response to glucose stimulus	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cellular response to insulin stimulus	IEA Inferred from Electronic Annotation more info	PubMed
involved_in gluconeogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in glycerol biosynthetic process from pyruvate	IEA Inferred from Electronic Annotation more info	PubMed
involved_in hepatocyte differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in propionate catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to starvation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: phosphoenolpyruvate carboxykinase, cytosolic [GTP]

Names: PEPCK-C; phosphoenolpyruvate carboxykinase 1 (soluble); phosphoenolpyruvate carboxykinase, cytosolic; phosphoenolpyruvate carboxylase; serine-protein kinase PCK1

NP_777162.1

EC 4.1.1.32

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174737.2 → NP_777162.1 phosphoenolpyruvate carboxykinase, cytosolic [GTP]

See identical proteins and their annotated locations for NP_777162.1

Status: PROVISIONAL

Source sequence(s)

AY145503

UniProtKB/Swiss-Prot

Q8HYZ4

UniProtKB/TrEMBL

Q2KIE8

Related

ENSBTAP00000002520.6, ENSBTAT00000002520.7

Conserved Domains (1) summary

cd00819
Location:27 → 615

PEPCK_GTP; Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and ...