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Slc6a15 solute carrier family 6 member 15 [ Rattus norvegicus (Norway rat) ]

Gene ID: 282712, updated on 17-Aug-2024

Summary

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Official Symbol
Slc6a15provided by RGD
Official Full Name
solute carrier family 6 member 15provided by RGD
Primary source
RGD:628664
See related
EnsemblRapid:ENSRNOG00000027468 AllianceGenome:RGD:628664
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ntt73
Summary
Predicted to enable proline:sodium symporter activity. Predicted to be involved in leucine transport; proline transport; and sodium ion transmembrane transport. Predicted to be integral component of plasma membrane. Orthologous to human SLC6A15 (solute carrier family 6 member 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 160.2) See more
Orthologs
human mouse all
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Genomic context

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See Slc6a15 in Genome Data Viewer
Location:
7q21
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (40439607..40493788)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (38553055..38607239)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (45328207..45381920)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene leucine-rich repeats and IQ motif containing 1 Neighboring gene uncharacterized LOC134479679 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene uncharacterized LOC120093576 Neighboring gene U6 spliceosomal RNA Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Neurotransmitter transporter family cDNAs in a rat midbrain library: 'orphan transporters' suggest sizable structural variations. Uhl GR, et al. Brain Res Mol Brain Res, 1992 Dec. PMID 1363329
  2. Deletion of v7-3 (SLC6A15) transporter allows assessment of its roles in synaptosomal proline uptake, leucine uptake and behaviors. Drgonova J, et al. Brain Res, 2007 Dec 5. PMID 17931606, Free PMC Article
  3. Characterization of a branched-chain amino-acid transporter SBAT1 (SLC6A15) that is expressed in human brain. Takanaga H, et al. Biochem Biophys Res Commun, 2005 Nov 25. PMID 16226721
  4. Synaptic Vesicle Protein NTT4/XT1 (SLC6A17) Catalyzes Na+-coupled Neutral Amino Acid Transport. Zaia KA, et al. J Biol Chem, 2009 Mar 27. PMID 19147495, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables branched-chain amino acid:sodium symporter activity ISO
Inferred from Sequence Orthology
more info
  
enables branched-chain amino acid:sodium symporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables neutral L-amino acid:sodium symporter activity ISO
Inferred from Sequence Orthology
more info
  
enables neutral L-amino acid:sodium symporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables proline:sodium symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables proline:sodium symporter activity ISO
Inferred from Sequence Orthology
more info
  
enables proline:sodium symporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in L-leucine transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-leucine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in carboxylic acid transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in neurotransmitter transport IEA
Inferred from Electronic Annotation
more info
  
involved_in neutral amino acid transport ISO
Inferred from Sequence Orthology
more info
  
involved_in neutral amino acid transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proline transport ISO
Inferred from Sequence Orthology
more info
  
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
sodium-dependent neutral amino acid transporter B(0)AT2
Names
orphan sodium- and chloride-dependent neurotransmitter transporter NTT73
orphan transporter v7-3
sodium- and chloride-dependent neurotransmitter transporter NTT73
solute carrier family 6 (neurotransmitter transporter), member 15
solute carrier family 6 (neutral amino acid transporter), member 15
transporter v7-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172321.4 → NP_758824.1  sodium-dependent neutral amino acid transporter B(0)AT2

    See identical proteins and their annotated locations for NP_758824.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    Q08469, Q63838
    UniProtKB/TrEMBL
    A6IGB4
    Conserved Domains (1) summary
    cd11522
    Location:61 → 640
    SLC6sbd_SBAT1; Sodium-coupled branched-chain amino-acid transporter 1; solute-binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    40439607..40493788
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039078522.2 → XP_038934450.1  sodium-dependent neutral amino acid transporter B(0)AT2 isoform X1

    UniProtKB/Swiss-Prot
    Q08469, Q63838
    UniProtKB/TrEMBL
    A6IGB4
    Related
    ENSRNOP00000032996.4, ENSRNOT00000029208.7
    Conserved Domains (1) summary
    cd11522
    Location:61 → 640
    SLC6sbd_SBAT1; Sodium-coupled branched-chain amino-acid transporter 1; solute-binding domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08469.1 GenPept UniProtKB/Swiss-Prot:Q08469

Gene LinkOut

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