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PSEN1 presenilin 1 [ Bos taurus (domestic cattle) ]

Gene ID: 282705, updated on 17-Aug-2024

Summary

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Official Symbol
PSEN1provided by VGNC
Official Full Name
presenilin 1provided by VGNC
Primary source
VGNC:VGNC:33434
See related
BGD:BT10847; Ensembl:ENSBTAG00000011757
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See PSEN1 in Genome Data Viewer
Location:
chromosome: 10
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 10 NC_037337.1 (84619645..84686876)

Chromosome 10 - NC_037337.1Genomic Context describing neighboring genes Neighboring gene transfer RNA glutamic acid (anticodon UUC) Neighboring gene RNA binding motif protein 25 Neighboring gene papilin, proteoglycan like sulfated glycoprotein Neighboring gene NUMB endocytic adaptor protein Neighboring gene HEAT repeat containing 4 Neighboring gene ribosomal oxygenase 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037337.1 Chromosome 10 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. γ-Secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1. Cai J, et al. J Biol Chem, 2011 Dec 9. PMID 22016384, Free PMC Article
  2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. gamma-Secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1
    Title: γ-Secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables aspartic endopeptidase activity, intramembrane cleaving IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables beta-catenin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cadherin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Notch receptor processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in amyloid precursor protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in amyloid-beta metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in calcium ion transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in membrane protein ectodomain proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in smooth endoplasmic reticulum calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in Z disc IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in ciliary rootlet IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in dendritic shaft IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in growth cone IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in neuromuscular junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
presenilin-1
Names
PS-1
presenilin 1 (Alzheimer disease 3)
NP_777146.1
XP_005211988.1
XP_005211989.1
XP_015328710.1
XP_059746218.1
XP_059746219.1
XP_059746220.1
XP_059746221.1
XP_059746222.1
XP_059746223.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174721.2 → NP_777146.1  presenilin-1

    See identical proteins and their annotated locations for NP_777146.1

    Status: PROVISIONAL

    Source sequence(s)
    AF038936
    UniProtKB/Swiss-Prot
    Q9XT97
    UniProtKB/TrEMBL
    F6RMU4
    Conserved Domains (1) summary
    pfam01080
    Location:77 → 468
    Presenilin; Presenilin

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037337.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    84619645..84686876
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059890236.1 → XP_059746219.1  presenilin-1 isoform X1

    UniProtKB/Swiss-Prot
    Q9XT97
    UniProtKB/TrEMBL
    F6RMU4

  2. XM_059890235.1 → XP_059746218.1  presenilin-1 isoform X1

    UniProtKB/Swiss-Prot
    Q9XT97
    UniProtKB/TrEMBL
    F6RMU4

  3. XM_059890239.1 → XP_059746222.1  presenilin-1 isoform X3

    UniProtKB/TrEMBL
    A7MBA9, F6RMU4

  4. XM_059890238.1 → XP_059746221.1  presenilin-1 isoform X2

    UniProtKB/TrEMBL
    A0AAF6ZE42, F6RMU4
    Related
    ENSBTAP00000040765.2, ENSBTAT00000043175.3

  5. XM_059890240.1 → XP_059746223.1  presenilin-1 isoform X5

    UniProtKB/TrEMBL
    A0AAF6ZSR9, F6RMU4
    Related
    ENSBTAP00000057240.2, ENSBTAT00000068561.2

  6. XM_059890237.1 → XP_059746220.1  presenilin-1 isoform X1

    UniProtKB/Swiss-Prot
    Q9XT97
    UniProtKB/TrEMBL
    F6RMU4

  7. XM_005211932.5 → XP_005211989.1  presenilin-1 isoform X1

    See identical proteins and their annotated locations for XP_005211989.1

    UniProtKB/Swiss-Prot
    Q9XT97
    UniProtKB/TrEMBL
    F6RMU4
    Conserved Domains (1) summary
    pfam01080
    Location:77 → 468
    Presenilin; Presenilin

  8. XM_005211931.5 → XP_005211988.1  presenilin-1 isoform X1

    See identical proteins and their annotated locations for XP_005211988.1

    UniProtKB/Swiss-Prot
    Q9XT97
    UniProtKB/TrEMBL
    F6RMU4
    Related
    ENSBTAP00000015615.5, ENSBTAT00000015615.6
    Conserved Domains (1) summary
    pfam01080
    Location:77 → 468
    Presenilin; Presenilin

  9. XM_015473224.3 → XP_015328710.1  presenilin-1 isoform X4

    UniProtKB/TrEMBL
    A0A3Q1MEI7
    Related
    ENSBTAP00000069430.2, ENSBTAT00000086321.2
    Conserved Domains (1) summary
    pfam01080
    Location:67 → 458
    Presenilin; Presenilin
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9XT97.1 GenPept UniProtKB/Swiss-Prot:Q9XT97

Gene LinkOut

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