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has3 hyaluronan synthase 3 [ Danio rerio (zebrafish) ]

Gene ID: 282555, updated on 30-Jun-2024

Summary

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Official Symbol
has3provided by ZNC
Official Full Name
hyaluronan synthase 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-021118-1
See related
Ensembl:ENSDARG00000057210 AllianceGenome:ZFIN:ZDB-GENE-021118-1
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
dg42III; af190743gs2; xx:af190743gs1; xx:af190743gs2
Summary
Predicted to enable hyaluronan synthase activity. Predicted to be involved in extracellular matrix assembly; extracellular polysaccharide biosynthetic process; and hyaluronan biosynthetic process. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in hypochord; median fin fold; nervous system; otic vesicle; and pectoral fin. Orthologous to human HAS3 (hyaluronan synthase 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See has3 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (17025187..17038147, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (17037566..17048310, complement)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene TBC1 domain family, member 15 Neighboring gene CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) Neighboring gene transport and golgi organization 6 homolog (Drosophila) Neighboring gene interleukin 17c

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Ancient origin of lubricated joints in bony vertebrates. Askary A, et al. Elife, 2016 Jul 19. PMID 27434666, Free PMC Article
  2. Cx43-Dependent Skeletal Phenotypes Are Mediated by Interactions between the Hapln1a-ECM and Sema3d during Fin Regeneration. Govindan J, et al. PLoS One, 2016. PMID 26828861, Free PMC Article
  3. Has2 is required upstream of Rac1 to govern dorsal migration of lateral cells during zebrafish gastrulation. Bakkers J, et al. Development, 2004 Feb. PMID 14729574
  4. Extracellular component hyaluronic acid and its receptor Hmmr are required for epicardial EMT during heart regeneration. Missinato MA, et al. Cardiovasc Res, 2015 Sep 1. PMID 26156497, Free PMC Article
  5. Hyaluronic acid synthesis is required for zebrafish tail fin regeneration. Ouyang X, et al. PLoS One, 2017. PMID 28207787, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables hyaluronan synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hyaluronan synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables hyaluronan synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in extracellular matrix assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in extracellular polysaccharide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hyaluronan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within hyaluronan biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
hyaluronan synthase 3
NP_775327.2
XP_009291796.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173220.2 → NP_775327.2  hyaluronan synthase 3

    Status: VALIDATED

    Source sequence(s)
    BX950194
    UniProtKB/TrEMBL
    A0A8M1PDY9, Q1LUE8
    Related
    ENSDARP00000074268.3, ENSDART00000079817.5
    Conserved Domains (2) summary
    cd06434
    Location:82 → 364
    GT2_HAS; Hyaluronan synthases catalyze polymerization of hyaluronan
    TIGR04242
    Location:11 → 466
    nodulat_NodC; chitooligosaccharide synthase NodC

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    17025187..17038147 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009293521.3 → XP_009291796.1  hyaluronan synthase 3 isoform X1

    UniProtKB/TrEMBL
    A0A8M3AJI3
    Conserved Domains (2) summary
    cd06434
    Location:85 → 367
    GT2_HAS; Hyaluronan synthases catalyze polymerization of hyaluronan
    TIGR04242
    Location:14 → 469
    nodulat_NodC; chitooligosaccharide synthase NodC

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395338.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    232419..235521 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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