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Slco1a1 solute carrier organic anion transporter family, member 1a1 [ Mus musculus (house mouse) ]

Gene ID: 28248, updated on 28-Oct-2024

Summary

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Official Symbol
Slco1a1provided by MGI
Official Full Name
solute carrier organic anion transporter family, member 1a1provided by MGI
Primary source
MGI:MGI:1351891
See related
Ensembl:ENSMUSG00000041698 AllianceGenome:MGI:1351891
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Oatp1; OATP-1; Oatp1a1; Slc21a1; A530084B21
Summary
Enables organic anion transmembrane transporter activity. Involved in response to stilbenoid. Acts upstream of or within organic anion transport. Located in basolateral plasma membrane. Is expressed in brain ventricular layer; liver; metanephros; submandibular gland primordium; and thymus primordium. Orthologous to human SLCO1A2 (solute carrier organic anion transporter family member 1A2). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in liver adult (RPKM 3.1) and liver E18 (RPKM 0.2) See more
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Genomic context

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See Slco1a1 in Genome Data Viewer
Location:
6 G2; 6 73.09 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (141853007..141892688, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (141907281..141946962, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene solute carrier organic anion transporter family, member 1a4 Neighboring gene predicted gene, 30784 Neighboring gene predicted gene, 30843 Neighboring gene solute carrier organic anion transporter family, member 1a8 Neighboring gene STARR-seq mESC enhancer starr_17699 Neighboring gene solute carrier organic anion transporter family, member 1a6 Neighboring gene predicted gene, 18159

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Endocrine regulation of gender-divergent mouse organic anion-transporting polypeptide (Oatp) expression. Cheng X, et al. Mol Pharmacol, 2006 Oct. PMID 16807376
  2. Organic anion transporting polypeptide 1a1 null mice are sensitive to cholestatic liver injury. Zhang Y, et al. Toxicol Sci, 2012 Jun. PMID 22461449, Free PMC Article
  3. Loss of organic anion transporting polypeptide 1a1 increases deoxycholic acid absorption in mice by increasing intestinal permeability. Zhang Y, et al. Toxicol Sci, 2011 Dec. PMID 21914718, Free PMC Article
  4. Molecular cloning and functional characterization of the mouse organic-anion-transporting polypeptide 1 (Oatp1) and mapping of the gene to chromosome X. Hagenbuch B, et al. Biochem J, 2000 Jan 1. PMID 10600646, Free PMC Article
  5. Functional analysis and androgen-regulated expression of mouse organic anion transporting polypeptide 1 (Oatp1) in the kidney. Isern J, et al. Biochim Biophys Acta, 2001 Mar 19. PMID 11267661

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibition of hepatic bile salt uptake by Bulevirtide reduces atherosclerosis in Oatp1a1[-/-]Ldlr[-/-] mice.
    Title: Inhibition of hepatic bile salt uptake by Bulevirtide reduces atherosclerosis in Oatp1a1(-/-)Ldlr(-/-) mice.
  2. Organic anion-transporting polypeptides exert strong impact on disposition and toxicity of antitumor drugs. (Review)
    Title: The impact of Organic Anion-Transporting Polypeptides (OATPs) on disposition and toxicity of antitumor drugs: Insights from knockout and humanized mice.
  3. important roles for OATP1A/1B in transporter-mediated uptake and disposition of doxorubicin, are reported.
    Title: Contribution of Organic Anion-Transporting Polypeptides 1A/1B to Doxorubicin Uptake and Clearance.
  4. Data indicate that organic anion-transporting polypeptides Oatp1a/1b-null mice had increased levels of carboxylesterase (Ces) enzymes, which caused higher conversion of irinotecan to SN-38 in plasma, potentially complicating pharmacokinetic analyses.
    Title: OATP1A/1B transporters affect irinotecan and SN-38 pharmacokinetics and carboxylesterase expression in knockout and humanized transgenic mice.
  5. PDZK1 regulates intracellular trafficking of Oatp1a1.
    Title: Oatp1a1 requires PDZK1 to traffic to the plasma membrane by selective recruitment of microtubule-based motor proteins.
  6. Loss of Oatp1a1 function exacerbates cholestatic liver injury in mice and suggest that Oatp1a1 plays a unique role in liver adaptive responses to obstructive cholestasis.
    Title: Organic anion transporting polypeptide 1a1 null mice are sensitive to cholestatic liver injury.
  7. Dysfunction of organic anion transporting polypeptide 1a1 alters intestinal bacteria and bile acid metabolism.
    Title: Dysfunction of organic anion transporting polypeptide 1a1 alters intestinal bacteria and bile acid metabolism in mice.
  8. Oatp1a1 is more highly expressed in males than in females. Null mice showed inhibited hepatocyte transporter functions and an altered urinary metabolome.
    Title: Characterization of organic anion-transporting polypeptide (Oatp) 1a1 and 1a4 null mice reveals altered transport function and urinary metabolomic profiles.
  9. Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs.
    Title: Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs.
  10. Report critical role of PPAR-alpha in perfluorooctanoic acid- and perfluorodecanoic acid-induced downregulation of Oatp1a1 uptake transporter in mouse liver.
    Title: Critical role of PPAR-alpha in perfluorooctanoic acid- and perfluorodecanoic acid-induced downregulation of Oatp uptake transporters in mouse livers.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables bile acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables organic anion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables organic anion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables sodium-independent organic anion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in bile acid and bile salt transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within organic anion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to stilbenoid IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to testosterone IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium-independent organic anion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in basal plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
solute carrier organic anion transporter family member 1A1
Names
sodium-independent organic anion-transporting polypeptide 1
solute carrier family 21 (organic anion transporter), member 1
solute carrier family 21 member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013797.5 → NP_038825.1  solute carrier organic anion transporter family member 1A1

    See identical proteins and their annotated locations for NP_038825.1

    Status: VALIDATED

    Source sequence(s)
    AC156277, AF223067, BB848260
    Consensus CDS
    CCDS39691.1
    UniProtKB/Swiss-Prot
    Q9QXZ6
    UniProtKB/TrEMBL
    Q53ZW9, Q7TQB3
    Related
    ENSMUSP00000037022.6, ENSMUST00000042119.6
    Conserved Domains (3) summary
    cd06174
    Location:23 → 396
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    cd01330
    Location:436 → 488
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    TIGR00805
    Location:1 → 625
    oat; sodium-independent organic anion transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    141853007..141892688 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QXZ6.1 GenPept UniProtKB/Swiss-Prot:Q9QXZ6

Gene LinkOut

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