SLC6A8 solute carrier family 6 member 8 [Bos taurus (domestic cattle)] - Gene

Summary

Gene symbol: SLC6A8
Gene description: solute carrier family 6 member 8
See related: Ensembl:ENSBTAG00000009959
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: X

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	X	NC_037357.1 (36914289..36921866)

Chromosome X - NC_037357.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037357.1 Chromosome X Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GSK3ss down-regulates the creatine transporter CreaT, an effect reversed by treatment with the antidepressant Lithium and by co-expression of PKB/Akt.
Title: Down-Regulation of the Na+,Cl- Coupled Creatine Transporter CreaT (SLC6A8) by Glycogen Synthase Kinase GSK3ß.
The observations suggest that SGK1 regulates the creatine transporter SLC6A8 at least partially through phosphorylation and activation of PIKfyve.
Title: PIKfyve in the SGK1 mediated regulation of the creatine transporter SLC6A8.
Mammalian target of rapamycin (mTOR) stimulates the creatine transporter SLC6A8 through mechanisms at least partially shared by the serum and glucocorticoid-inducible kinase SGK1.
Title: Stimulation of the creatine transporter SLC6A8 by the protein kinase mTOR.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables creatine:sodium symporter activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in neurotransmitter transport	IEA Inferred from Electronic Annotation more info	PubMed
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: sodium- and chloride-dependent creatine transporter 1

Names: CT1; choline transporter; creatine transporter 1; solute carrier family 6 (neurotransmitter transporter, creatine), member 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174611.2 → NP_777036.1 sodium- and chloride-dependent creatine transporter 1

See identical proteins and their annotated locations for NP_777036.1

Status: PROVISIONAL

Source sequence(s)

AF027197

UniProtKB/Swiss-Prot

O18875

UniProtKB/TrEMBL

A0AAA9RY06

Related

ENSBTAP00000013141.6, ENSBTAT00000013141.6

Conserved Domains (1) summary

cd11509
Location:52 → 621

SLC6sbd_CT1; Na(+)- and Cl(-)-dependent creatine transporter 1; solute-binding domain