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SLC6A2 solute carrier family 6 member 2 [ Bos taurus (domestic cattle) ]

Gene ID: 282363, updated on 4-Oct-2024

Summary

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Official Symbol
SLC6A2provided by VGNC
Official Full Name
solute carrier family 6 member 2provided by VGNC
Primary source
VGNC:VGNC:34920
See related
Ensembl:ENSBTAG00000003353
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See SLC6A2 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 18 NC_037345.1 (23885168..23927951)

Chromosome 18 - NC_037345.1Genomic Context describing neighboring genes Neighboring gene lysophosphatidylcholine acyltransferase 2 Neighboring gene U6 spliceosomal RNA Neighboring gene calpain small subunit 2 Neighboring gene transfer RNA phenylalanine (anticodon GAA) Neighboring gene transfer RNA glycine (anticodon CCC) Neighboring gene 60S ribosomal protein L13 pseudogene Neighboring gene uncharacterized LOC132342811 Neighboring gene carboxylesterase 1 (monocyte/macrophage serine esterase 1)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037345.1 Chromosome 18 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning and expression of the bovine sodium- and chloride-dependent noradrenaline transporter. Lingen B, et al. FEBS Lett, 1994 Apr 11. PMID 8150077
  2. Structure, function and brain localization of neurotransmitter transporters. Jursky F, et al. J Exp Biol, 1994 Nov. PMID 7823028
  3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables dopamine:sodium symporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables neurotransmitter:sodium symporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables norepinephrine:sodium symporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in dopamine uptake involved in synaptic transmission IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in norepinephrine transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in neuronal cell body membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in presynaptic membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
sodium-dependent noradrenaline transporter
Names
NET
norepinephrine transporter
solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174608.2 → NP_777033.1  sodium-dependent noradrenaline transporter

    See identical proteins and their annotated locations for NP_777033.1

    Status: PROVISIONAL

    Source sequence(s)
    X79015
    UniProtKB/Swiss-Prot
    P51143
    UniProtKB/TrEMBL
    A0A3Q1N0K4
    Related
    ENSBTAP00000004354.2, ENSBTAT00000004354.3
    Conserved Domains (1) summary
    cl00456
    Location:54 → 613
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037345.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    23885168..23927951
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015475703.3 → XP_015331189.1  sodium-dependent noradrenaline transporter isoform X1

    UniProtKB/TrEMBL
    A0A3Q1MQW2, A0A3Q1N0K4
    Related
    ENSBTAP00000074026.2, ENSBTAT00000079158.2
    Conserved Domains (1) summary
    cl00456
    Location:54 → 610
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  2. XM_024977953.2 → XP_024833721.1  sodium-dependent noradrenaline transporter isoform X2

    UniProtKB/TrEMBL
    A0A3Q1M4L9, A0A3Q1MWL4
    Related
    ENSBTAP00000064756.2, ENSBTAT00000068559.2
    Conserved Domains (1) summary
    cl00456
    Location:54 → 582
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P51143.1 GenPept UniProtKB/Swiss-Prot:P51143

Gene LinkOut

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Molecular Biology Databases
Research Materials