PTGER2 prostaglandin E receptor 2 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: PTGER2provided by VGNC
Official Full Name: prostaglandin E receptor 2provided by VGNC
Primary source: VGNC:VGNC:33502
See related: BGD:BT22916; Ensembl:ENSBTAG00000002163
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	10	NC_037337.1 (11826430..11838823, complement)

Chromosome 10 - NC_037337.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037337.1 Chromosome 10 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that OVGP1 expression in oviductal epithelial cells is enhanced by PGE2 via PTGER2-cAMP-PKA signaling, and reduced by PGF2alpha through PTGFR-Ca2+-PKC pathway. (OVGP1 = oviductal glycoprotein 1; PTGER2 = prostaglandin E2 receptor; PTGFR = prostaglandin F2-alpha receptor; PKA = cyclic AMP-dependent protein kinase; PKC = protein kinase C)
Title: The prostaglandin E(2) receptor PTGER2 and prostaglandin F(2α) receptor PTGFR mediate oviductal glycoprotein 1 expression in bovine oviductal epithelial cells.
Data suggested that PTGS-2 gene expression was induced by PTGER2 activation through the PKA and ERK pathways.
Title: PTGER2 activation induces PTGS-2 and growth factor gene expression in endometrial epithelial cells of cattle.
The results indicated that mRNA and protein expression of connective tissue growth factor (CTGF), fibroblast growth factor-2 (FGF-2), interleukin-8 (IL-8), transforming growth factor-beta1 (TGF-beta1), matrix metalloproteinase-2 (MMP-2), and vascular endothelial growth factor A (VEGFA) were up-regulated after PTGER2 activation by corresponding agonist butaprost
Title: The effect of prostaglandin E(2) receptor (PTGER2) activation on growth factor expression and cell proliferation in bovine endometrial explants.
Data suggest that lysophosphatidic acid (LPA) up-regulates expression of SLCO2A1 (prostaglandin [PG] transporter), PTGER2/PTGER4 (PG receptors EP2/EP4), and mPGES1/cPGES (microsomal/cytosolic PG E synthases) in luteal cells.
Title: Lysophosphatidic acid modulates prostaglandin signalling in bovine steroidogenic luteal cells.
Data suggest that estradiol up-regulates mRNA and protein expression of 3 prostanoid receptors in oviduct smooth muscle: EP2/PTGER2 (prostaglandin E receptor 2); EP4/PTGER4 (prostaglandin E receptor 4); and FP/PTGFR (prostaglandin F2alpha receptor).
Title: Prostanoid receptors EP2, EP4, and FP are regulated by estradiol in bovine oviductal smooth muscle.
Quantitative RT-PCR revealed significant higher expression of EP2 and EP4 in the pre-ovulatory phase compared with the luteal phase in the bovine oviduct
Title: Exploring cumulus-oocyte-complex-oviductal cell interactions: gene profiling in the bovine oviduct.
COX-2 and FP receptor contribute via changes in amount and distribution to mechanisms associated with parturition.
Title: Immunohistochemical demonstration of cyclooxygenase-2 (COX-2) and prostaglandin receptors EP2 and FP expression in the bovine intercaruncular uterine wall around term.
EP2 is the major cAMP-generating PGE(2) receptor expressed and regulated in the bovine uterus during the estrous cycle and early pregnancy.
Title: Molecular cloning and characterization of bovine prostaglandin E2 receptors EP2 and EP4: expression and regulation in endometrium and myometrium during the estrous cycle and early pregnancy.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables prostaglandin E receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cellular response to prostaglandin E stimulus	IEA Inferred from Electronic Annotation more info	PubMed
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: prostaglandin E2 receptor EP2 subtype

Names: prostaglandin E receptor 2 (subtype EP2), 53kDa; prostaglandin E2 receptor EP2 subtype pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.