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HYOU1 hypoxia up-regulated 1 [ Bos taurus (domestic cattle) ]

Gene ID: 282295, updated on 17-Aug-2024

Summary

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Official Symbol
HYOU1provided by VGNC
Official Full Name
hypoxia up-regulated 1provided by VGNC
Primary source
VGNC:VGNC:50032
See related
BGD:BT14870; Ensembl:ENSBTAG00000010322
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
GRP170; ORP150
Orthologs
human mouse all
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Genomic context

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See HYOU1 in Genome Data Viewer
Location:
chromosome: 15
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 15 NC_037342.1 (29631218..29653246, complement)

Chromosome 15 - NC_037342.1Genomic Context describing neighboring genes Neighboring gene trafficking protein particle complex subunit 4 Neighboring gene solute carrier family 37 member 4 Neighboring gene VPS11 core subunit of CORVET and HOPS complexes Neighboring gene hydroxymethylbilane synthase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Comparative analysis of 82 expressed sequence tags from a cattle ovary cDNA library. Ma RZ, et al. Mamm Genome, 1998 Jul. PMID 9657852
  2. Establishment of a high throughput EST sequencing system using poly(A) tail-removed cDNA libraries and determination of 36,000 bovine ESTs. Takasuga A, et al. Nucleic Acids Res, 2001 Nov 15. PMID 11713328, Free PMC Article
  3. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in endoplasmic reticulum unfolded protein response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of endoplasmic reticulum chaperone complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
hypoxia up-regulated protein 1
Names
glucose regulated protein, 170 kDa
oxygen regulated protein, 150 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001206910.1 → NP_001193839.1  hypoxia up-regulated protein 1 precursor

    See identical proteins and their annotated locations for NP_001193839.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AV667435, BE722782, CB443436, CK772437, CN435952, DN546651, DT809461, DV883195, DV888816, EV694702
    UniProtKB/TrEMBL
    A0A3Q1M1A5
    Related
    ENSBTAP00000064965.2, ENSBTAT00000072953.2
    Conserved Domains (3) summary
    cd10230
    Location:36 → 424
    HYOU1-like_NBD; Nucleotide-binding domain of human HYOU1 and similar proteins
    PHA03169
    Location:587 → 698
    PHA03169; hypothetical protein; Provisional
    cl26761
    Location:554 → 797
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

  2. NM_001206911.1 → NP_001193840.1  hypoxia up-regulated protein 1 precursor

    See identical proteins and their annotated locations for NP_001193840.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AV667435, CB443436, CK772437, CN435952, DN546651, DV883195, DV888816, EV650393, EV694702
    UniProtKB/TrEMBL
    A0A3Q1M1A5
    Conserved Domains (3) summary
    cd10230
    Location:36 → 424
    HYOU1-like_NBD; Nucleotide-binding domain of human HYOU1 and similar proteins
    PHA03169
    Location:587 → 698
    PHA03169; hypothetical protein; Provisional
    cl26761
    Location:554 → 797
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037342.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    29631218..29653246 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005215907.5 → XP_005215964.1  hypoxia up-regulated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005215964.1

    UniProtKB/TrEMBL
    A0A3Q1M1A5, A0A3Q1MBP1
    Conserved Domains (3) summary
    cd10230
    Location:36 → 424
    HYOU1-like_NBD; Nucleotide-binding domain of human HYOU1 and similar proteins
    COG0443
    Location:38 → 669
    DnaK; Molecular chaperone DnaK (HSP70) [Posttranslational modification, protein turnover, chaperones]
    pfam06459
    Location:549 → 697
    RR_TM4-6; Ryanodine Receptor TM 4-6

  2. XM_005215906.5 → XP_005215963.1  hypoxia up-regulated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005215963.1

    UniProtKB/TrEMBL
    A0A3Q1M1A5, A0A3Q1MBP1
    Related
    ENSBTAP00000074586.2, ENSBTAT00000066893.2
    Conserved Domains (3) summary
    cd10230
    Location:36 → 424
    HYOU1-like_NBD; Nucleotide-binding domain of human HYOU1 and similar proteins
    COG0443
    Location:38 → 669
    DnaK; Molecular chaperone DnaK (HSP70) [Posttranslational modification, protein turnover, chaperones]
    pfam06459
    Location:549 → 697
    RR_TM4-6; Ryanodine Receptor TM 4-6

  3. XM_005215905.5 → XP_005215962.1  hypoxia up-regulated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005215962.1

    UniProtKB/TrEMBL
    A0A3Q1M1A5, A0A3Q1MBP1
    Related
    ENSBTAP00000066108.2, ENSBTAT00000075055.2
    Conserved Domains (3) summary
    cd10230
    Location:36 → 424
    HYOU1-like_NBD; Nucleotide-binding domain of human HYOU1 and similar proteins
    COG0443
    Location:38 → 669
    DnaK; Molecular chaperone DnaK (HSP70) [Posttranslational modification, protein turnover, chaperones]
    pfam06459
    Location:549 → 697
    RR_TM4-6; Ryanodine Receptor TM 4-6

  4. XM_024975023.2 → XP_024830791.1  hypoxia up-regulated protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A3Q1M1A5
    Conserved Domains (3) summary
    cd10230
    Location:36 → 424
    HYOU1-like_NBD; Nucleotide-binding domain of human HYOU1 and similar proteins
    PHA03169
    Location:587 → 698
    PHA03169; hypothetical protein; Provisional
    cl26761
    Location:554 → 797
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

  5. XM_010812420.4 → XP_010810722.1  hypoxia up-regulated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_010810722.1

    UniProtKB/TrEMBL
    A0A3Q1M1A5, A0A3Q1MBP1
    Conserved Domains (3) summary
    cd10230
    Location:36 → 424
    HYOU1-like_NBD; Nucleotide-binding domain of human HYOU1 and similar proteins
    COG0443
    Location:38 → 669
    DnaK; Molecular chaperone DnaK (HSP70) [Posttranslational modification, protein turnover, chaperones]
    pfam06459
    Location:549 → 697
    RR_TM4-6; Ryanodine Receptor TM 4-6
Nucleotide Protein Strain
Heading Accession and Version

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