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NDUFV2 NADH:ubiquinone oxidoreductase core subunit V2 [ Bos taurus (domestic cattle) ]

Gene ID: 282290, updated on 10-Oct-2024

Summary

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Official Symbol
NDUFV2provided by VGNC
Official Full Name
NADH:ubiquinone oxidoreductase core subunit V2provided by VGNC
Primary source
VGNC:VGNC:31975
See related
BGD:BT13794; Ensembl:ENSBTAG00000004871
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See NDUFV2 in Genome Data Viewer
Location:
chromosome: 24
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 24 NC_037351.1 (41415091..41433991)

Chromosome 24 - NC_037351.1Genomic Context describing neighboring genes Neighboring gene microtubule crosslinking factor 1 Neighboring gene uncharacterized LOC107131785 Neighboring gene uncharacterized LOC100849069 Neighboring gene ankyrin repeat domain 12 Neighboring gene WAS/WASL-interacting protein family member 1-like Neighboring gene twisted gastrulation BMP signaling modulator 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037351.1 Chromosome 24 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Superoxide generation from mitochondrial NADH dehydrogenase induces self-inactivation with specific protein radical formation. Chen YR, et al. J Biol Chem, 2005 Nov 11. PMID 16150735
  2. The primary structure of subunit II of NADH dehydrogenase from bovine-heart mitochondria. von Bahr-Lindström H, et al. Eur J Biochem, 1983 Jul 15. PMID 6861757
  3. cDNA of the 24 kDa subunit of the bovine respiratory chain NADH dehydrogenase: high sequence conservation in mammals and tissue-specific and growth-dependent expression. Chomyn A, et al. Curr Genet, 1989 Aug. PMID 2598272
  4. Structure of mammalian respiratory complex I. Zhu J, et al. Nature, 2016 Aug 18. PMID 27509854, Free PMC Article
  5. Possible roles of two quinone molecules in direct and indirect proton pumps of bovine heart NADH-quinone oxidoreductase (complex I). Ohnishi ST, et al. Biochim Biophys Acta, 2010 Dec. PMID 20599678, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that during NADH-ubiquinone oxidoreductase (Complex I) catalytic electron transfer from NADH to DBQ, the superoxide generation site was mostly shifted to the SQ.
    Title: New insights into the superoxide generation sites in bovine heart NADH-ubiquinone oxidoreductase (Complex I): the significance of protein-associated ubiquinone and the dynamic shifting of generation sites between semiflavin and semiquinone radicals.
  2. Data suggest that Q(Nf) plays a role in a "direct" redox-driven proton pump, while Q(Ns) triggers an "indirect" conformation-driven proton pump in NADH-ubiquinone oxidoreductase (complex I).
    Title: Possible roles of two quinone molecules in direct and indirect proton pumps of bovine heart NADH-quinone oxidoreductase (complex I).
  3. The catalytic function of NDH in the mediation of superoxide generation was investigated by EPR spin-trapping.
    Title: Superoxide generation from mitochondrial NADH dehydrogenase induces self-inactivation with specific protein radical formation.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables NADH dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial electron transport, NADH to ubiquinone IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
Names
NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa
NADH dehydrogenase flavoprotein 2
NADH dehydrogenase subunit II
NADH-ubiquinone oxidoreductase 24 kDa subunit
NADH-ubiquinone reductase 24 kDa mitochondrial
NP_776990.1
XP_059736743.1
XP_059736744.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174565.3 → NP_776990.1  NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial precursor

    See identical proteins and their annotated locations for NP_776990.1

    Status: VALIDATED

    Source sequence(s)
    DT883895, GH324961, X14724
    UniProtKB/Swiss-Prot
    P04394, Q3T0G9
    UniProtKB/TrEMBL
    A0AAA9TE61
    Related
    ENSBTAP00000095061.1, ENSBTAT00000088947.1
    Conserved Domains (1) summary
    pfam01257
    Location:63 → 209
    2Fe-2S_thioredx; Thioredoxin-like [2Fe-2S] ferredoxin

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037351.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    41415091..41433991
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059880760.1 → XP_059736743.1  NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0AAF6ZLD4
    Related
    ENSBTAP00000052906.3, ENSBTAT00000006405.6

  2. XM_059880761.1 → XP_059736744.1  NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P04394.3 GenPept UniProtKB/Swiss-Prot:P04394

Gene LinkOut

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